A Randomized, Double-Blind, Controlled Withdrawal Trial in Crohn’s Disease Patients in Long-term Remission on Azathioprine

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Treatment of Crohn's Disease with 6-Mercaptopurine

1980 • 1,055 citations

Azathioprine and 6-Mercaptopurine in Crohn Disease

1995 • 966 citations

“Proving the null hypothesis” in clinical trials

1982 • 870 citations

Development and validation of an endoscopic index of the severity for Crohn's disease: a prospective multicentre study. Groupe d'Etudes Therapeutiques des Affections Inflammatoires du Tube Digestif (GETAID).

1989 • 833 citations

Low-Molecular-Weight Heparin in the Treatment of Patients with Venous Thromboembolism

1997 • 785 citations

6-Mercaptopurine in the Management of Inflammatory Bowel Disease: Short- and Long-Term Toxicity

1989 • 757 citations

A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease

2000 • 724 citations

The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review

2002 • 642 citations

A controlled double blind study of azathioprine in the management of Crohn's disease.

1995 • 583 citations

Rederived values of the eight coefficients of the Crohn's Disease Activity Index (CDAI)

1979 • 566 citations

Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease

1994 • 501 citations

Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.

1993 • 501 citations

Long-term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine

1996 • 480 citations

Crohn's Disease and Cancer

1973 • 473 citations

A Trial of Shortened Zidovudine Regimens to Prevent Mother-to-Child Transmission of Human Immunodeficiency Virus Type 1

2000 • 439 citations

Smoking cessation and the course of Crohn's disease: An intervention study

2001 • 419 citations

Significance Testing to Establish Equivalence between Treatments, with Special Reference to Data in the Form of 2 x 2 Tables

1977 • 400 citations

Azathioprine for maintenance of remission in Crohn's disease

1998 • 318 citations

Crohn's disease and cancer: A population-based cohort study

1994 • 311 citations

Epstein-Barr virus–positive lymphoma in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine

2002 • 271 citations

Increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low

2000 • 265 citations

Proving the null hypothesis.

1991 • 259 citations

Azathioprine for maintenance of remission in Crohn's disease: Benefits outweigh the risk of lymphoma

2000 • 251 citations

The relationship between infliximab treatment and lymphoma in Crohn's disease

1999 • 208 citations

Long‐term risk of malignancy after treatment of inflammatory bowel disease with azathioprine

2002 • 201 citations

Risk of lymphoma in inflammatory bowel disease

2000 • 151 citations

Risk of lymphoma in inflammatory bowel disease

2000 • 148 citations

Malignant Neoplasms Subsequent to Treatment of Inflammatory Bowel Disease With 6-Mercaptopurine

1999 • 141 citations

Epstein-Barr Virus–Positive Primary Gastrointestinal Hodgkin's Disease

2000 • 126 citations

Fatal infectious mononucleosis: a severe complication in the treatment of Crohn's disease with azathioprine.

1995 • 93 citations

Optimum Duration of Treatment With 6-Mercaptopurine for Crohn's Disease

1999 • 79 citations

Cancer Clinical Trials

1988 • 40 citations

Prediction of relapse in patients with Crohnʼs disease in remission

1994 • 31 citations

An unusual complication of immunosuppressive therapy in inflammatory bowel disease.

1997 • 23 citations

Immunosuppressors for Inflammatory Bowel Disease: How Long Is Long Enough?

2000 • 19 citations

Biological markers of short term relapse in Crohn's disease (CD)

2001 • 18 citations

Immunosuppressors for inflammatory bowel disease: How long is long enough?

2007 • 9 citations

Fatal infectious mononucleosis

1995 • 1 citations

Deleted Work

1955 • 0 citations