The Use of Beta-Adrenoceptor Blocking Drugs in Hypertension: A Review

Factors Influencing Infarct Size Following Experimental Coronary Artery Occlusions

1971 • 1,500 citations

Propranolol Inhibition of Renin Secretion

1972 • 729 citations

REDUCTION OF SUDDEN DEATHS AFTER MYOCARDIAL INFARCTION BY TREATMENT WITH ALPRENOLOL

1974 • 466 citations

Treatment of Hypertension with Propranolol

1969 • 426 citations

Beta adrenergic blockade in hypertension

1972 • 425 citations

Use of Propranolol (Inderal) in Treatment of Hypertension

1964 • 407 citations

POSSIBLE ROLE OF A β‐ADRENOCEPTOR IN THE REGULATION OF NORADRENALINE RELEASE BY NERVE STIMULATION THROUGH A POSITIVE FEED‐BACK MECHANISM

1975 • 334 citations

Unwanted effects of propranolol

1966 • 300 citations

Improvement in prognosis of myocardial infarction by long-term beta-adrenoreceptor blockade using practolol. A multicentre international study.

1975 • 293 citations

Treatment of Essential Hypertension with Combined Vasodilation and Beta-Adrenergic Blockade

1972 • 274 citations

Antihypertensive beta blocking action as related to renin and age: A pharmacologic tool to identify pathogenetic mechanisms in essential hypertension

1975 • 273 citations

The Paradox of Beta-Adrenergic Blockade in Hypertension

1968 • 265 citations

SCLEROSING PERITONITIS, AN UNUSUAL REACTION TO A β-ADRENERGIC-BLOCKING DRUG (PRACTOLOL)

1974 • 262 citations

ELECTROCARDIOGRAM, PLASMA CATECHOLAMINES AND LIPIDS, AND THEIR MODIFICATION BY OXPRENOLOL WHEN SPEAKING BEFORE AN AUDIENCE

1973 • 245 citations

Adrenergic Receptor Mediation of Renin Secretion

1969 • 243 citations

The Effect of Chronic Adrenergic Receptor Blockade on Plasma Renin Activity in Man

1972 • 233 citations

Treatment of Essential Hypertension with a New Vasodilator in Combination with Beta-Adrenergic Blockade

1970 • 221 citations

Effects of Autonomic Blockade on the Baroreflex in Man at Rest and During Exercise

1972 • 221 citations

Propranolol in hypertension: A study of long-term therapy, 1964–1970

1972 • 218 citations

Perspectives in adrenergic beta‐receptor blockade

1969 • 217 citations

Cutaneous and Ocular Reactions to Practolol

1974 • 200 citations

Dual Adrenoceptor‐mediated Control of Noradrenaline Secretion from Human Vasoconstrictor Nerves: Facilitation by β‐receptors and Inhibition by α‐receptors

1975 • 185 citations

Reversal of Abnormal Platelet Aggregability and Change in Exercise Tolerance in Patients with Angina Pectoris Following Oral Propranolol

1974 • 183 citations

Immediate Hemodynamic Effects of Beta-Adrenergic Blockade with Propranolol in Normotensive and Hypertensive Man

1968 • 180 citations

Hypotensive Action of Pronethalol

1964 • 178 citations

Clinical pharmacology of beta‐receptor‐blocking drugs

1969 • 163 citations

Adverse Reactions to ??-Adrenergic Receptor Blocking Drugs

1974 • 150 citations

Propranolol in hypertension

1966 • 147 citations

REDUCTION OF SUDDEN DEATHS AFTER MYOCARDIAL INFARCTION

1974 • 146 citations

A study of the mechanism of the hemodynamic effects of hydralazine in man.

1963 • 145 citations

Systemic Lupus Erythematosus Syndrome Induced by Practolol

1973 • 142 citations

-Blockers and Plasma Renin Activity in Hypertension

1974 • 135 citations

Brain concentration of propranolol in relation to hypotensive effect in the rabbit with observations on brain propranolol levels in man.

1975 • 132 citations

Inhibition by -blockade of the ST segment elevation after acute myocardial infarction in man

1972 • 124 citations

Plasma Propranolol Levels Associated with Suppression of Ventricular Ectopic Beats

1971 • 117 citations

β-Adrenergic Blockade in Diuretic-Treated Patients with Essential Hypertension

1975 • 116 citations

Hypertensive and Renin-Suppressing Activities of Propranolol in Hypertensive Patients

1975 • 115 citations

Inhibition by β-blockade of the ST segment elevation after acute myocardial infarction in man

2000 • 114 citations

Plasma levels and effects of metoprolol on blood pressure and heart rate in hypertensive patients after an acute dose and between two doses during long‐term treatment

1975 • 113 citations

Plasma volume changes with long-term beta-adrenergic blockade

1971 • 109 citations

Bethanidine, Guanethidine, and Methyldopa in Treatment of Hypertension: a Within-patient Comparison

1968 • 109 citations

??-Adrenergic Receptor Blocking Drugs in Hypertension

1974 • 108 citations

Ineffectiveness of propranolol in hypertensive Jamaicans.

1968 • 108 citations

Unexpected pressor responses to propranolol in essential hypertension

1976 • 108 citations

Assessment of alpha‐ and beta‐adrenoceptor blocking actions of labetalol.

1976 • 104 citations

Assessment of propranolol in angina pectoris. Clinical dose response curve and effect on electrocardiogram at rest and on exercise.

1971 • 104 citations

Central Hypotensive Activity of dl- and d-Propranolol

1970 • 103 citations

EFFECT OF ALPRENOLOL ON BLOOD PRESSURE AND PLASMA RENIN ACTIVITY IN HYPERTENSIVE PATIENTS

1973 • 99 citations

Controlled Trial of Propranolol in Hypertension

1970 • 93 citations

The metabolism and distribution of the selective adrenergic beta blocking agent, practolol.

1970 • 93 citations

??-Adrenergic Receptor Blocking Drugs in Angina Pectoris

1974 • 89 citations

Once-daily dosing with Atenolol in patients with mild or moderate hypertension.

1976 • 89 citations

Hypotensive action of propranolol

1966 • 89 citations

Comparative antihypertensive effects and tissue distribution of beta adrenergic blocking drugs.

1975 • 89 citations

Acute and long-term studies of the mechanisms of action of beta-blocking drugs in lowering blood pressure

1976 • 86 citations

Aggression and atheroma.

1973 • 85 citations

Beta‐adrenergic receptor blocking drugs, hypertension and plasma renin.

1975 • 84 citations

EFFECTS OF BETA-ADRENERGIC BLOCKADE DURING EXERCISE IN HYPERTENSIVE AND ISCHqMIC HEART-DISEASE

1967 • 83 citations

The rise in clotting factor VIII induced in man by adrenaline: effect of α‐ and β‐blockers

1966 • 81 citations

Propranolol in the Treatment of Hypertension

1976 • 80 citations

ALPHA AND BETA ADRENERGIC BLOCKADE IN HYPERTENSION

1972 • 80 citations

Pharmacokinetics of propranolol: a review.

1976 • 80 citations

Labetalol in long-term treatment of hypertension.

1976 • 80 citations

Pharmacological effects of labetalol in man.

1976 • 79 citations

Beta-adrenergic blockade in essential hypertension. Effects of propranolol on hemodynamic parameters and plasma renin activity.

1973 • 78 citations

AGGRESSION AND ATHEROMA

1969 • 77 citations

THE EFFECTS OF SYMPATHECTOMY ON THE ELECTROCARDIOGRAM AND EFFORT TOLERANCE IN ANGINA PECTORIS

1964 • 76 citations

Effect of Propranolol on Elevated Arterial Blood Pressure

1968 • 75 citations

Comparison of Adrenergic Beta-receptor Antagonists in Angina Pectoris

1973 • 74 citations

Controlled study of atenolol in treatment of hypertension.

1975 • 73 citations

EFFECT OF PROPRANOLOL IN MILD HYPERTENSION

1966 • 72 citations

The effects of propranolol on cholesterol-induced atheromatous lesions

1973 • 72 citations

Evaluation of Long-Term Use of Propranolol in Angina Pectoris

1969 • 72 citations

The relationship of plasma levels of pindolol in hypertensive patients to effects on blood pressure, plasma renin and plasma noradrenaline levels

1975 • 71 citations

Altered renin release and propranolol potentiation of vasodilatory drug hypotension.

1975 • 71 citations

The use of propranolol in the treatment of hypertension.

1973 • 70 citations

TREATMENT OF HYPERTENSION WITH PROPRANOLOL AND HYDRALAZINE

1971 • 68 citations

Compared Incidence of First Myocardial Infarction in Hypertensive Patients under Treatment Containing Propranolol or excluding β-Receptor Blockade

1976 • 67 citations

THE USE OF PRINDOLOL (VISKEN) IN THE TREATMENT OF HYPERTENSION

1972 • 67 citations

SUPPRESSION BY OXPRENOLOL OF ADRENERGIC RESPONSE TO STRESS

1972 • 67 citations

ANTIHYPERTENSIVE THERAPY WITH ALPRENOLOL, Aβ‐ADRENERGIC RECEPTOR ANTAGONIST

1969 • 67 citations

On the mechanism of suppressed plasma-renin activity during beta-adrenergic blockade with propranolol.

1974 • 66 citations

Hemodynamic Long‐term Effects of Timolol at Rest and during Exercise in Essential Hypertension

1976 • 64 citations

Effect of Beta-Adrenergic Blockade on Plasma Volume in Human Subjects

1972 • 63 citations

Adverse Effects of ??-Adrenergic Receptor Blocking Drugs on Respiratory Function

1974 • 62 citations

Haemodynamic long‐term effects of a new beta‐adrenoceptor blocking drug, atenolol (ICI 66082), in essential hypertension.

1976 • 62 citations

Chronic beta adrenergic blockade in arterial hypertension

1972 • 59 citations

Mechanism of hypotensive effect during beta-adrenergic blockade in hypertensive patients

1976 • 57 citations

The Relative Efficacy of Guanethidine, Methyldopa and Pargyline as Antihypertensive Agents

1965 • 56 citations

Plasma Volume and Extracellular Fluid Volume during Long-Term Treatment with Propranolol in Essential Hypertension

1972 • 52 citations

The action of intravenous oxprenolol, practolol, propranolol and sotalol on acute exercise tolerance in angina pectoris: the effect on heart rate and the electrocardiogram.

1970 • 51 citations

Long-term beta blockade: possible protection from myocardial infarction.

1975 • 51 citations

Some Haemodynamic Effects of Compound AH 5158 Compared with Propranolol, Propranolol plus Hydrallazine, and Diazoxide: The Use of AH 5158 in the Treatment of Hypertension

1974 • 51 citations

Pindolol, (Visken, LB46). A new treatment for hypertension: report of a multicentric open study.

1972 • 51 citations

COMPARISON BETWEEN ALPRENOLOL AND CHLORTHALIDONE AS ANTIHYPERTENSIVE AGENTS

1972 • 50 citations

CARDIOVASCULAR EFFECTS OF ?-ADRENORECEPTOR BLOCKING AGENTS AFTER INTRACEREBROVENTRICULAR ADMINISTRATION IN CONSCIOUS NORMOTENSIVE CATS

1974 • 50 citations

Adrenergic neuron blocking properties of (±)-propranolol and (+)-propranolol

1970 • 50 citations

Propranolol in hypertension

1966 • 46 citations

Cardiovascular responses to carotid and vertebral artery infusions of propranolol

1971 • 45 citations

Haemodynamic studies in hypertensive patients treated by oral propranolol

1970 • 43 citations

Propranolol therapy in essential hypertension. Observations on predictability of therapeutic response.

1974 • 43 citations

Controlled Trial of Oxprenolol and Practolol in Hypertension

1970 • 43 citations

Effects of propranolol on the pressor response to noxious stimuli in hypertensive patients

1968 • 41 citations

Centrally induced hypotensive effects of β-adrenergic blocking drugs

1975 • 41 citations

Carcinoma of the ampulla of Vater in a haemophiliac patient

1976 • 41 citations

Systemic circulatory response to stress of simulated flight and to physical exercise before and after propranolol blockade.

1967 • 40 citations

Timolol

1975 • 40 citations

TWICE-DAILY PROPRANOLOL TREATMENT FOR HYPERTENSION

1971 • 38 citations

EFFECT OF APTIN, A β‐ADRENERGIC BLOCKING AGENT, IN ARTERIAL HYPERTENSION

1969 • 37 citations

A comparison of timolol and propranolol in essential hypertension

1975 • 37 citations

Inhibitory effect of propranolol on the vasoconstrictor response to sympathetic nerve stimulation

1970 • 36 citations

Inhibition of the carotid sinus reflex by the chronic administration of propranolol

1969 • 36 citations

Comparative studies on central factors contributing to the hypotensive action of propranolol, alprenolol, and their enantiomers

1974 • 35 citations

BETA BLOCKERS AND BLOOD VISCOSITY

1976 • 34 citations

Different Effects of Adrenergic Beta-receptor Blockade on Heart Rate Response to Mental Stress, Catecholamines, and Exercise

1973 • 34 citations

DOUBLE‐BLIND COMPARISON OF TWO BETA‐BLOCKING DRUGS WITH PREVIOUS THERAPY IN THE TREATMENT OF HYPERTENSION

1974 • 32 citations

Hemodynamic and therapeutic effects of guancydine in hypertension

1971 • 31 citations

Anti-Hypertensive Effect of Timolol, a New Beta-Blocking Agent (Double-Blind Study)

1975 • 31 citations

HEMODYNAMIC EFFECTS OF PROPRANOLOL (INDERAL®) AND H 56/28 (APTIN®) IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

1969 • 30 citations

Propranolol in the South African non-white hypertensive patient.

1971 • 30 citations

Haemodynamic effects of propranolol in hypertension: a review.

1976 • 30 citations

BLOOD VOLUME AND EXCHANGEABLE SODIUM DURING TREATMENT OF HYPERTENSION WITH GUANETHIDINE AND HYDROCHLOROTHIAZIDE

1969 • 30 citations

Albumin Transcapillary Escape Rate and Plasma Volume during Long-Term Beta-Adrenergic Blockade in Essential Hypertension

1973 • 30 citations

A CONTROLLED STUDY OF PRINDOLOL (VISKEN) IN HYPERTENSION

1972 • 29 citations

Pindolol in hypertension: a double-blind trial.

1972 • 29 citations

Advances in Beta-adrenergic blocking therapy: Sotalol

1976 • 28 citations

Pindolol: a comparison with other antihypertensive drugs and a double-blind placebo trial.

1974 • 26 citations

Central hypotensive effect of propranolol.

1976 • 25 citations

Cortisol levels in depression.

1976 • 23 citations

Myocarditis complicating cytomegalovirus mononucleosis

1976 • 22 citations

Effect of propranolol on mortality in patients with angina.

1976 • 19 citations

REDUCTION IN THE RISE OF SYSTOLIC BLOOD PRESSURE DURING HUMAN COITUS BY THE -ADRENERGIC BLOCKING AGENT, PROPRANOLOL

1970 • 19 citations

VASODILATORS IN THE TREATMENT OF HYPERTENSION

1975 • 18 citations

Propranolol in hypertension

1968 • 17 citations

Discussion

1976 • 17 citations

Beta receptor antagonism in hypertension; comparison with the effect of adrenergic neurone inhibition on cardiovascular responses.

1970 • 16 citations

A Within-patient Comparison of Debrisoquine and Methyldopa in Hypertension

1971 • 16 citations

The effect of pindolol on plasma renin activity and blood pressure in hypertensive patients.

1976 • 15 citations

A Within-Patient Comparison of Bethanidine, Methyldopa and Propranolol in the Treatment of Hypertension

1976 • 14 citations

Effects of β-Adrenoreceptor Blocking Drugs on Plasma Volume, Renin and Aldosterone as Components of Their Antihypertensive Action

1976 • 12 citations

HYPOTENSION AFTER ORAL PROPRANOLOL

1968 • 12 citations

Experiences with beta-adrenergic blockade drugs in hypertension.

1973 • 12 citations

The antihypertensive action of several beta-adrenoreceptor-blocking drugs.

1976 • 12 citations

Beta-blockade and angina pectoris: a controlled multi-centre clinical trial

1969 • 12 citations

HYPOTENSION AFTER ORAL PROPRANOLOL

1968 • 11 citations

The Treatment of Hypertension by Beta Adrenergic Blocking Drugs

1966 • 11 citations

The relationship between beta-blockade, hyporeninaemic and hypotensive effect of two beta-blocking agents.

1976 • 10 citations

Alprenolol Treatment of Angina Pectoris

1971 • 10 citations

A Total of 254 cases of Angina Pectoris treated with Oxprenolol in Hospital Practice — a Monitored Release Study

1972 • 9 citations

Effects of practolol on pressor responses to noxious stimuli in hypertensive patients

1973 • 9 citations

Hypotensive action from combination of propranolol and other hypotensive drugs.

1971 • 8 citations

A total of 254 cases of angina pectoris treated with oxprenolol in hospital practice--a monitored release study.

1972 • 8 citations

Twice-daily pindolol and alprenolol in essential hypertension of moderate severity.

1976 • 8 citations

Treatment of hypertension with propranol.

1969 • 8 citations

The combined effect of propranolol with bethanidine or methyldopa in hypertension.

1976 • 8 citations

Proceedings: Effects of cardioselective beta-blockers on chest pain, ECG, and heart function in acute myocardial infarction.

1976 • 7 citations

Effect of Beta Adrenergic Blocking Agents (Alprenolol and Propranolol) in Essential Hypertension

1975 • 6 citations

[Clinical evaluation of propranolol in the treatment of hypertension].

1967 • 5 citations

Swedish Society of Cardiology and the British Cardiac Society

1976 • 4 citations