Swinholide A Is a Microfilament Disrupting Marine Toxin That Stabilizes Actin Dimers and Severs Actin Filaments

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Regulation of Rabbit Skeletal Muscle Contraction

1971 • 4,491 citations

Effects of cytochalasin and phalloidin on actin.

1987 • 1,989 citations

Inhibition of actin polymerization by latrunculin A

1987 • 813 citations

Fluorimetry study of N-(1-pyrenyl)iodoacetamide-labelled F-actin. Local structural change of actin protomer both on polymerization and on binding of heavy meromyosin.

1981 • 811 citations

Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.

1994 • 798 citations

Fluorimetry Study of N‐(1‐Pyrenyl)iodoacetamide‐Labelled F‐Actin

1981 • 694 citations

Latrunculins—novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D

1989 • 566 citations

Characterization of actin filament severing by actophorin from Acanthamoeba castellanii.

1991 • 247 citations

Ca2+ control of actin filament length. Effects of macrophage gelsolin on actin polymerization.

1981 • 217 citations

Assignment of DNA binding sites for 4′,6-diamidine-2-phenylindole and bisbenzimide (Hoechst 33258). A comparative footprinting study

1988 • 212 citations

Reduction in Viscosity of Cystic Fibrosis Sputum in Vitro by Gelsolin

1994 • 207 citations

Structure of swinholide-a, a new macrolide from the marine sponge

1985 • 188 citations

Probing actin polymerization by intermolecular cross-linking.

1988 • 118 citations

Kinetic analysis of F-actin depolymerization in the presence of platelet gelsolin and gelsolin-actin complexes.

1985 • 95 citations

Different calcium dependence of the capping and cutting activities of villin.

1986 • 87 citations

F-actin is intermolecularly crosslinked by N,N'-p-phenylenedimaleimide through lysine-191 and cysteine-374.

1984 • 83 citations

Marine natural products. XXII. The absolute stereostructure of swinholide A, a potent cytotoxic dimeric macrolide from the Okinawa marine sponge Theonella swinhoei.

1990 • 73 citations

Molecular conformation of swinholide A, a potent cytotoxic dimeric macrolide from the Okinawan marine sponge Theonella swinhoei: x-ray crystal structure of its diketone derivative

1991 • 73 citations

Total Synthesis of Swinholide A and Hemiswinholide A

1994 • 73 citations

The actin monomers in the ternary gelsolin: 2 actin complex are in an antiparallel orientation

1993 • 72 citations

Cytochalasin D does not produce net depolymerization of actin filaments in HEp-2 cells

1980 • 68 citations

Pentoxifylline attenuates neutrophil activation in experimental endotoxemia in chimpanzees.

1993 • 64 citations

The actin side-binding domain of gelsolin also caps actin filaments. Implications for actin filament severing

1994 • 62 citations

Bound-cation exchange affects the lag phase in actin polymerization

1984 • 61 citations

Direct observation of actin filament severing by gelsolin and binding by gCap39 and CapZ.

1991 • 60 citations

Action of tolytoxin on cell morphology, cytoskeletal organization, and actin polymerization

1993 • 58 citations

Marine Natural Products. XXIV. : The Absolute Stereostructure of Misakinolide A, a Potent Cytotoxic Dimeric Macrolide from an Okinawan Marine Sponge Theonella sp.

1990 • 55 citations

Phalloidin attenuates postischemic neutrophil infiltration and increased microvascular permeability

1991 • 50 citations

Marine Natural Products. XXXI. Structure-Activity Correlation of a Potent Cytotoxic Dimeric Macrolide Swinholide A, from the Okinawan Marine Sponge Theonella swinhoei, and Its Isomers.

1994 • 47 citations

Cytochalasin B and the structure of actin gels II. Further evidence for the splitting of F-actin by cytochalasin B

1980 • 46 citations

The isolation of a monomeric carboxylic acid of swinholide a from the indo-pacific sponge, theonella swinhoei

1992 • 43 citations

Molecular characteristics of G-ADP actin

1964 • 43 citations

Actin depolymerization and inhibition of capping induced by pentoxifylline in human lymphocytes and neutrophils

1988 • 41 citations

Actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery

1988 • 32 citations

The binding of cytochalasin D to monomeric actin

1985 • 31 citations

Comparative study on effects of cytochalasins B and D on F-actin content in different cell lines and different culture conditions.

1992 • 22 citations