Regulation of human colonic cell line proliferation and phenotype by sodium butyrate

Short chain fatty acids in human large intestine, portal, hepatic and venous blood.

1987 • 2,744 citations

Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man.

1980 • 1,265 citations

Assay of intestinal disaccharidases

1968 • 1,211 citations

Utilization of Nutrients by Isolated Epithelial Cells of the Rat Colon

1982 • 1,136 citations

Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: a possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors

1987 • 656 citations

Fecal weight, colon cancer risk, and dietary intake of nonstarch polysaccharides (dietary fiber)

1992 • 464 citations

Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2

1992 • 375 citations

Occurrence, absorption and metabolism of short chain fatty acids in the digestive tract of mammals

1987 • 357 citations

Different accessibilities in chromatin to histone acetylase.

1979 • 340 citations

Histone acetylation and control of gene expression

1991 • 331 citations

Alterations in human colonic mucin occurring with cellular differentiation and malignant transformation.

1982 • 331 citations

Effect of sodium butyrate on mammalian cells in culture: A review

1976 • 327 citations

New chromogenic substrates for X-prolyl dipeptidyl-aminopeptidase

1976 • 316 citations

Clinical pharmacology of sodium butyrate in patients with acute leukemia

1987 • 249 citations

Effects of sodium butyrate and dimethylsulfoxide on biochemical properties of human colon cancer cells

1980 • 237 citations

Butyric acid: A small fatty acid with diverse biological functions

1980 • 236 citations

HIGH COLONIC pH PROMOTES COLORECTAL CANCER

1981 • 220 citations

Effects of short‐chain fatty acids on growth and differentiation of the human colon‐cancer cell line HT29

1992 • 197 citations

Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor.

1992 • 190 citations

Stimulatory effect of short chain fatty acids on the epithelial cell proliferation in rat large intestine

1983 • 172 citations

Effects of sodium butyrate on human colonic adenocarcinoma cells. Induction of placental-like alkaline phosphatase.

1987 • 153 citations

Effect of dietary fibers on rat large bowel mucosal growth and cell proliferation

1984 • 139 citations

Colonic fermentation of dietary fibre to short chain fatty acids in patients with adenomatous polyps and colonic cancer.

1991 • 129 citations

Short chain fatty acid distributions of enema samples from a sigmoidoscopy population: an association of high acetate and low butyrate ratios with adenomatous polyps and colon cancer.

1988 • 127 citations

Wheat bran suppresses potato starch--potentiated colorectal tumorigenesis at the aberrant crypt stage in a rat model

1996 • 123 citations

Induction of tumor cell differentiation as a therapeutic approach: preclinical models for hematopoietic and solid neoplasms.

1986 • 109 citations

Effects of Dietary Wheat Bran Fiber on Rectal Epithelial Cell Proliferation in Patients With Research for Colorectal Cancers

1990 • 107 citations

Distribution of a 69-kD laminin-binding protein in aortic and microvascular endothelial cells: modulation during cell attachment, spreading, and migration.

1988 • 94 citations

Derivatives of butyric acid as potential anti‐neoplastic agents

1991 • 92 citations

Effects of differing concentrations of sodium butyrate on 1,2-dimethylhydrazine-induced rat intestinal neoplasia

1986 • 91 citations

In vivo Inhibition of Growth of Two Hormone-Dependent Mammary Tumors by Dibutyryl Cyclic AMP

1974 • 91 citations

Effect of sodium butyrate on alkaline phosphatase in HRT-18, a human rectal cancer cell line.

1982 • 84 citations

Independent modulation of enterocyte migration and proliferation by growth factors, matrix proteins, and pharmacologic agents in an in vitro model of mucosal healing.

1992 • 84 citations

DNA hypermethylation in sodium butyrate-treated WI-38 fibroblasts.

1986 • 70 citations

Effect of sodium butyrate on carcinoembryonic antigen production by human colonic adenocarcinoma cells in culture.

1983 • 69 citations

Short-chain fatty acid absorption in rabbit colon in vitro

1990 • 68 citations

Effect of Cyclic AMP on Growth and Morphological Differentiation of an Established Myogenic Cell Line

1973 • 68 citations

Stretch-induced growth in chicken wing muscles: nerve-muscle interaction in muscular dystrophy

1984 • 67 citations

Influence of luminal pH on rat large bowel epithelial cell cycle

1985 • 57 citations

High-fiber diets: influence on characteristics of cecal digesta including short-chain fatty acid concentrations and pH

1989 • 54 citations

Sodium butyrate-induced alteration of growth properties and glycogen levels in cultured human colon carcinoma cells

1984 • 47 citations

Stable differentiation of a human colon adenocarcinoma cell line by sodium butyrate is associated with multidrug resistance

1994 • 41 citations

Butyric monosaccharide ester‐induced cell differentiation and anti‐tumor activity in mice. Importance of their prolonged biological effect for clinical applications in cancer therapy

1991 • 40 citations

Antibody-mediated targeting of differentiation inducers to tumor cells: Inhibition of colonic cancer cell growth in vitro and in vivo a preliminary note

1989 • 35 citations

Effect of the dietary fibre content of lifelong diet on colonic cellular proliferation in the rat.

1992 • 32 citations

Induction of tyrosine aminotransferase in HTC cells by N6, O2′-dibutyryl adenosine 3′, 5′-monophosphate

1972 • 30 citations

Diet and Large Bowel Cancer

1990 • 24 citations

Dietary fiber and gastrointestinal disease.

1993 • 14 citations

Immunization against a rat colon carcinoma by sodium butyrate-treated cells but not by interleukin 2-secreting cells

1995 • 13 citations