Embryonic and Uterine Expression Patterns of Peptidylglycine α-Amidating Monooxygenase Transcripts Suggest a Widespread Role for Amidated Peptides in Development

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

1994 • 1,138 citations

Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein-2A (BMP-2A)

1990 • 616 citations

The Biosynthesis Of Neuropeptides: Peptide Alpha-Amidation

1992 • 482 citations

Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats.

1995 • 365 citations

Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases

1995 • 348 citations

Growth-Promoting Effects of Glycine-Extended Progastrin

1994 • 336 citations

Peptidylglycine α‐amidating monooxygenase: A multifunctional protein with catalytic, processing, and routing domains

1993 • 263 citations

Localized expression of the atrial natriuretic factor gene during cardiac embryogenesis.

1987 • 234 citations

A staging system for mouse limb development

1989 • 221 citations

C-Terminal amidated peptides: Production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity

1994 • 219 citations

In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: implications for mode of action.

1994 • 196 citations

Eplthelial-Mesenchymal Signaling during Tooth Development

1995 • 185 citations

Expression of adrenomedullin in normal human lung and in pulmonary tumors

1995 • 183 citations

Pituitary adenylate cyclase-activating polypeptide is an autocrine inhibitor of mitosis in cultured cortical precursor cells

1997 • 180 citations

Peptides in the Nervous Systems of Cnidarians: Structure, Function, and Biosynthesis

1996 • 180 citations

PACAP Functions as a Neurotrophic Factora

1994 • 178 citations

Systematic isolation of peptide signal molecules regulating development in hydra: LWamide and PW families

1997 • 172 citations

Purification and Characterization of Carboxypeptidase D, a Novel Carboxypeptidase E-like Enzyme, from Bovine Pituitary

1995 • 154 citations

Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases.

1993 • 149 citations

The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity

1994 • 146 citations

Rat Parathyroid Hormone-Like Peptide: Comparison with the Human Homologue and Expression in Malignant and Normal Tissue

1989 • 139 citations

Molecular mechanisms of cell and tissue interactions during early tooth development

1996 • 124 citations

Induction of chondrogenesis: requirement for synergistic interaction of basic fibroblast growth factor and transforming growth factor-beta

1994 • 121 citations

Expression of TGF-βs and Their Receptors during Implantation and Organogenesis of the Mouse Embryo

1994 • 119 citations

Neuropeptide amidation in Drosophila: separate genes encode the two enzymes catalyzing amidation.

1997 • 116 citations

Alternative mRNA splicing generates multiple forms of peptidyl-glycine alpha-amidating monooxygenase in rat atrium.

1989 • 116 citations

Neuropeptide Amidation inDrosophila: Separate Genes Encode the Two Enzymes Catalyzing Amidation

1997 • 107 citations

Immunohistochemical mapping of neuropeptides in the premamillary region of the hypothalamus in rats

1995 • 106 citations

The Catalytic Core of Peptidylglycine .alpha.-Hydroxylating Monooxygenase: Investigation by Site-Directed Mutagenesis, Cu X-ray Absorption Spectroscopy, and Electron Paramagnetic Resonance

1995 • 104 citations

Evidence for galanin receptors in primary sensory neurones and effect of axotomy and inflammation

1996 • 103 citations

Alternative splicing and endoproteolytic processing generate tissue-specific forms of pituitary peptidylglycine alpha-amidating monooxygenase (PAM).

1992 • 103 citations

Cloning and Expression of Human Carboxypeptidase Z, a Novel Metallocarboxypeptidase

1997 • 96 citations

Expression of activins and TGFβ1 and β2 RNAs in early postimplantation mouse embryos and uterine decidua

1992 • 93 citations

Gastrin and Glycine-extended Progastrin Processing Intermediates Induce Different Programs of Early Gene Activation

1995 • 86 citations

Developmental changes of pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor in the rat brain

1994 • 83 citations

Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary

1995 • 83 citations

Expression of galanin and a galanin receptor in several sensory systems and bone anlage of rat embryos

1996 • 82 citations

Mammalian Paired Basic Amino Acid Convertases of Prohormones and Proproteins^a

1993 • 76 citations

Expression of peptidylglycine alpha-amidating monooxygenase (EC 1.14.17.3) in the rat central nervous system

1992 • 72 citations

Developmental regulation of peptidylglycine α-amidating monooxygenase (PAM) in rat heart atrium and ventricle

1989 • 63 citations

Membrane-associated peptidylglycine alpha-amidating monooxygenase in the heart.

1988 • 63 citations

Characterization of novel mRNAs encoding enzymes involved in peptide alpha-amidation

1991 • 56 citations

The multifunctional peptidylglycine alpha-amidating monooxygenase gene: exon/intron organization of catalytic, processing, and routing domains.

1992 • 56 citations

Modulation of Chemotropism in the Developing Spinal Cord by Substance P

1995 • 54 citations

Development of the peptidergic innervation of human heart.

1993 • 52 citations

The Developmental Expression in the Rat CNS and Peripheral Tissues of Proteases PC5 and PACE4 mRNAs: Comparison with Other Proprotein Processing Enzymes

1997 • 41 citations

Expression of peptidylglycine alpha-amidating monooxygenase: an in situ hybridization and immunocytochemical study.

1992 • 38 citations

Purification and Characterization of PAM-1, an Integral Membrane Protein Involved in Peptide Processing

1994 • 37 citations

Topological Switching of the COOH-Terminal Domain of Peptidylglycine α-Amidating Monooxygenase by Alternative RNA Splicing

1993 • 36 citations

Primary Structure of the Precursor for the Anthozoan Neuropeptide Antho‐RFamide from Renilla köllikeri: Evidence for Unusual Processing Enzymes

1994 • 29 citations

Alternative splicing governs sulfation of tyrosine or oligosaccharide on peptidylglycine alpha-amidating monooxygenase.

1994 • 27 citations

Localization of amidating enzymes (PAM) in rat gastrointestinal tract.

1993 • 23 citations

Maturation, internalization, and turnover of soluble and membrane proteins associated with atrial myocyte secretory granules.

1993 • 22 citations

The multifunctional peptidylglycine alpha-amidating monooxygenase gene: exon/intron organization of catalytic, processing, and routing domains

1992 • 22 citations

[3] Analysis of ontogeny of processing enzyme gene expression and regulation

1995 • 21 citations

TRH and TRH-OH in the pancreas of adult and newborn rats

1985 • 17 citations

Evidence for high peptide α-amidation activity in the neonatal rat pancreas

1986 • 16 citations

Regulation of Carboxypeptidase E (Enkephalin Convertase)

1991 • 4 citations

Deleted Work

1955 • 0 citations