Assays of drug sensitivity for cells from human tumours: in vitro and in vivo tests on a xenografted tumour

Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.

1966 • 1,363 citations

Quantitation of Differential Sensitivity of Human-Tumor Stem Cells to Anticancer Drugs

1978 • 982 citations

An in vitro colony assay for human tumours grown in immune-suppressed mice and treated in vivo with cytotoxic agents

1978 • 296 citations

Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function.

1977 • 211 citations

Quantitative prediction of drug toxicity in humans from toxicology in small and large animals.

1975 • 132 citations

Improved immune-suppression techniques for the xenografting of human tumours

1978 • 131 citations

Pharmacokinetics and metabolism of vinblastine in humans.

1977 • 126 citations

Pharmaco-kinetics of melphalan following oral or intravenous administration in patients with malignant disease

1978 • 99 citations

In vitro studies with hexamethylmelamine

1977 • 81 citations

Variation in response of xenografts of colo-rectal carcinoma to chemotherapy

1978 • 74 citations

Differential sensitivities of five rat hepatoma cell lines to anticancer drugs.

1978 • 54 citations

Some observations on the human pharmacology of methotrexate.

1977 • 47 citations

Fresh explant culture of human tumours in vitro and the assessment of sensitivity to cytotoxic chemotherapy

1975 • 44 citations

Plasma levels and urinary excretion of hexamethylmelamine following oral administration to human subjects with cancer

1968 • 24 citations

Absorption and fate of C14-labeled N,N',N''-triethylenethiophosphoramide (thio-TEPA) in humans and dogs.

1962 • 24 citations

Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts

1977 • 16 citations

Pharmacodynamic and pharmacokinetic measurements of antitumor agents

1974 • 15 citations

TESTING ANTI-CANCER DRUGS

1972 • 8 citations

TESTING ANTI-CANCER DRUGS

1972 • 7 citations