Somatic DNA rearrangement generates functional rat immunoglobulin κ chain genes: The jk gene cluster is longer in rat than in mouse

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

1975 • 3,483 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

A complete immunoglobulin gene is created by somatic recombination.

1978 • 610 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody

1981 • 470 citations

Hybridization of RNA to double-stranded DNA: formation of R-loops.

1976 • 443 citations

Mapping of Deletions and Substitutions in Heteroduplex DNA Molecules of Bacteriophage Lambda by Electron Microscopy

1969 • 408 citations

Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments

1980 • 402 citations

Antibody diversity: Somatic hypermutation of rearranged VH genes

1981 • 334 citations

Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression

1981 • 319 citations

Intragenic DNA spacers interrupt the ovalbumin gene

1978 • 284 citations

A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation

1979 • 283 citations

The arrangement and rearrangement of antibody genes

1978 • 277 citations

Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain

1980 • 228 citations

Somatic mutation of immunoglobulin light-chain variable-region genes

1981 • 184 citations

Improved methods for the formation and stabilization of R-loops

1979 • 163 citations

[18] In Vitro packaging of λ dam vectors and their use in cloning DNA fragments

1979 • 162 citations

Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

1981 • 161 citations

Use of antibodies for the isolation of biologically pure messenger ribonucleic acid from fully functional eukaryotic cells

1974 • 100 citations

Structure and regulation of immunoglobulins: kappa allotypes in the rat have multiple amino-acid differences in the constant region.

1975 • 49 citations

An experimental approach to enumerate the genes coding for immunoglobulin variable-regions

1981 • 31 citations

Region of immunoglobulin light-chain mRNA transcribed into complementary DNA by RNA-dependent DNA polymerase of avian myeloblastosis virus.

1975 • 20 citations

Complex allotypes of rat κ chains are encoded by structural alleles

1981 • 15 citations

Structure of the components of the adenovirus-simian virus 40 hybrid population Ad2++HEY and reciprocal molecular interactions

1978 • 8 citations

Partial amino acid sequences of ?-chains of rat immunoglobulins: Genetic and evolutionary implications

1976 • 8 citations

Rat kappa-chain allotypes

1980 • 5 citations

Structure and function of immunoglobulin genes and precursors.

1979 • 5 citations