Critical issues in assessing the behavioral effects of amphetamine

Brain dopamine receptors.

1980 • 1,878 citations

Molecular pathology of schizophrenia: more than one disease process?

1980 • 1,877 citations

Amphetamines and related compounds

1971 • 979 citations

The Dopamine Hypothesis of Schizophrenia: A Review*

1976 • 862 citations

Drugs, Neurotransmitters, and Schizophrenia

1974 • 832 citations

Serotonergic component of neuroleptic receptors

1978 • 621 citations

Stereotyped activities produced by amphetamine in several animal species and man

1967 • 612 citations

Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy

1974 • 607 citations

Amphetamine Psychosis: A "Model" Schizophrenia Mediated by Catecholamines

1973 • 590 citations

The dopamine hypothesis of schizophrenia: focus on the dopamine receptor

1976 • 543 citations

Antipsychotic Drugs, Neurotransmitters, and Schizophrenia

1978 • 500 citations

Antischizophrenic Drugs and Brain Cholinergic Receptors

1974 • 474 citations

Cocaine and Other Stimulants

1977 • 421 citations

Neuropsychopharmacology of monoamines and their regulatory enzymes.

1974 • 416 citations

The Experimental Reproduction of Amphetamine Psychosis

1973 • 350 citations

Differential effects of amphetamine and neuroleptics on negative Vs. positive symptoms in schizophrenia

1980 • 347 citations

Comparison of Amphetamine Psychosis and Schizophrenia

1965 • 328 citations

An observational method for quantifying the behavioural effects of dopamine agonists: Contrasting effects of d-Amphetamine and apomorphine

1980 • 326 citations

Amphetamine abuse. Pattern and effects of high doses taken intravenously

1967 • 324 citations

Rating the behavioral effects of amphetamine

1974 • 278 citations

A Critique of the Methods Available for the Measurement of Spontaneous Motor Activity

1977 • 254 citations

Evolving Behavior in the Clinical and Experimental Amphetamine (Model) Psychosis

1973 • 253 citations

Amphetamine: Differentiation by d and l Isomers of Behavior Involving Brain Norepinephrine or Dopamine

1970 • 252 citations

Psychopharmacology: A Generation of Progress

1978 • 242 citations

Amphetamine models of paranoid schizophrenia: An overview and elaboration of animal experimentation.

1980 • 242 citations

Pharmacology and physiology of stereotyped behavior

1974 • 238 citations

Differential effects of D- and L-amphetamine on behavior and on catecholamine disposition in dopamine and norepinephrine containing neurons of rat brain

1971 • 235 citations

Biochemistry and Behavior: Some Central Actions of Amphetamine and Antipsychotic Drugs

1976 • 228 citations

Stereotyped behaviour patterns and hyperactivity induced by amphetamine and apomorphine after discrete 6-hydroxydopamine lesions of extrapyramidal and mesolimbic nuclei

1977 • 225 citations

Amphetamine-Induced Dopaminergic Hypersensitivity in Guinea Pigs

1975 • 221 citations

Conditioned drug effects and absence of tolerance to d-amphetamine induced motor activity

1973 • 210 citations

Behavioural and biochemical comparison of amphetamine derivatives, cocaine, benztropine and tricyclic anti-depressant drugs

1972 • 165 citations

Special antagonism of amphetamine-induced abnormal behaviour

1965 • 156 citations

A proposed natural geometry of recovery from akinesia in the lateral hypothalamic rat

1979 • 148 citations

Responses to apomorphine, amphetamine, and neuroleptics in schizophrenic subjects

1980 • 143 citations

Brain mechanisms of amphetamine-induced anorexia, locomotion, and stereotypy: A review

1978 • 142 citations

Stereotypy in monkeys and humans

1982 • 133 citations

Neurobiological mechanisms of adaptation and behavior

1975 • 133 citations

Apomorphine: Chemistry, Pharmacology, Biochemistry

1976 • 127 citations

The monoamine oxidase B inhibitor deprenyl potentiates phenylethylamine behaviour in rats without inhibition of catecholamine metabolite formation

1975 • 125 citations

Behavioral Characterization of d - and l -Amphetamine: Neurochemical Implications

1975 • 124 citations

Antipsychotic Drugs

1977 • 121 citations

Reverse tolerance to stimulant-induced abnormal behavior

1977 • 114 citations

Differences in the nature of the stereotyped behaviour induced by aporphine derivatives in the rat and in their actions in extrapyramidal and mesolimbic brain areas

1975 • 108 citations

Effects of clozapine, thioridazine, perlapine and haloperidol on the metabolism of the biogenic amines in the brain of the rat

1975 • 107 citations

The noradrenergic cyclic AMP generating system in the limbic forebrain: Pharmacological characterization in vitro and possible role of limbic noradrenergic mechanisms in the mode of action of antipsychotics

1976 • 104 citations

Amphetamine stereotypy: the influence of environmental factors and prepotent behavioral patterns on its topography and development.

1975 • 99 citations

Clozapine and the Dopamine Hypothesis of Schizophrenia, a Critical Appraisal

1975 • 99 citations

Behavioral implications of dopaminergic neurons in the mesolimbic system.

1977 • 95 citations

Amphetamine stereotypy is not a homogeneous phenomenon: Sniffing and licking show distinct profiles of sensitization and tolerance

1980 • 89 citations

"Warm-up" along dimensions of movement in the ontogeny of exploration in rats and other infant mammals.

1981 • 89 citations

Psychopathology Induced by “Speed Drugs”

1981 • 88 citations

Metabolic and experiential factors in the behavioral response to repeated amphetamine

1977 • 86 citations

In vivo actions of clozapine and haloperidol on the turnover rate of acetylcholine in rat striatum.

1976 • 82 citations

Apparent tolerance to some aspects of amphetamine stereotypy with long-term treatment

1980 • 82 citations

Fundamental mechanisms underlying altered behavior following chronic administration of psychomotor stimulants.

1980 • 80 citations

An open field study of stereotyped locomotor activity in amphetamine-treated rats

1979 • 77 citations

On the significance of the increase in homovanillic acid (HVA) caused by antipsychotic drugs in corpus striatum and limbic forebrain

1975 • 73 citations

Noradrenergic influence on the stereotyped behaviour induced by amphetamine, phenethylamine and apomorphine

1976 • 73 citations

Mesolimbic and Extrapyramidal Sites for the Mediation of Stereotyped Behaviour Patterns and Hyperactivity by Amphetamine and Apomorphine in the Rat

1977 • 71 citations

Relationships between selective denervation of dopamine terminal fields in the anterior forebrain and behavioral responses to amphetamine and apomorphine

1980 • 70 citations

Dopamine receptors: subtypes, localization and regulation.

1981 • 68 citations

Neuroleptic antagonism of dyskinetic phenomena

1975 • 66 citations

A pharmacological study of changes in central nervous system receptor responsiveness after long-term dexamphetamine and apomorphine administration

1978 • 64 citations

Brain locations controlling the behavioral effects of chronic amphetamine intoxication

1980 • 63 citations

Neuroleptics: Clinical Use in Psychiatry

1978 • 61 citations

Motor Subsystems in Motivated Behavior

1980 • 57 citations

Differential effects of D- and L-amphetamine and methylphenidate on rat striatal dopamine biosynthesis

1975 • 56 citations

Abnormal pattern of amphetamine locomotion after 6-OHDA lesion of anteromedial caudate

1979 • 54 citations

Differential sensitivity to amphetamine following long-term treatment with clozapine or haloperidol

1982 • 54 citations

Extrapyramidal side-effects

1979 • 48 citations

Environmentally induced differences in susceptibility of rats to CNS stimulants and CNS depressants: Evidence against a unitary explanation

1979 • 48 citations

Effects of chronic d-amphetamine on social behavior of the rat: Implications for an animal model of paranoid schizophrenia

1976 • 47 citations

Psychopharmacological Implications of Dopamine and Dopamine Antagonists: A Critical Evaluation of Current Evidence

1977 • 46 citations

Comparative effects of clozapine and α-adrenoceptor blocking drugs on regional noradrenaline metabolism in rat brain

1978 • 43 citations

Behavior and histopathological findings during chronic methedrine intoxication.

1970 • 39 citations

The effects of test environment and rearing condition on amphetamine-induced stereotypy in the guinea pig

1975 • 37 citations

Measurement of acute and chronic behavioural effects of methamphetamine in the mouse

1976 • 33 citations

Antipsychotic drug effects on dopamine and serotonin receptors: in vitro binding and in vivo turnover studies.

1981 • 31 citations

Neural Substrates Mediating Amphetamine Responses

1977 • 30 citations

A primate analogue of amphetamine-induced behaviors in humans.

1981 • 30 citations

The effect of dose, novelty, and exploration on amphetamine-produced stereotyped behavior

1978 • 30 citations

Social isolation and other behavioral changes in groups of adult vervet monkeys (Cercopithecus aethiops) produced by low, nonchronic doses of d-amphetamine

1979 • 26 citations

Influence of GABA-agonists and antagonists on neuroleptic-induced catalepsy in rats

1978 • 26 citations

Enhanced responsiveness to intraventricular infusion of amphetamine following its repeated systemic administration

1979 • 25 citations

AMPHETAMINE PSYCHOSIS

1959 • 24 citations

Effects of deafening and blindfolding on amphetamine induced stereotypy in the cat

1977 • 23 citations

Stimulant action of d-amphetamine in relation to test compartment dimensions and behavioral measure

1971 • 22 citations

Interaction of arena size with different measures of amphetamine effects

1977 • 20 citations

Circadian variation in an amphetamine induced motor response

1977 • 19 citations

Potentiation of haloperidol-induced catalepsy by dopamine agonists: Possible involvement of central 5-hydroxytryptamine

1979 • 18 citations

DISCONNECTION AND ANTAGONISTIC INTERACTION OF MOVEMENT SUBSYSTEMS IN MOTIVATED BEHAVIOR

1982 • 18 citations

Alteration of GABA receptors in rat substantia nigra after chronic treatment with antischizophrenic drugs

1980 • 18 citations

Deprivation-dependent effects of amphetamine on concurrent measures of feeding and activity

1980 • 17 citations

Physical vs. Psychological Dependence and Tolerance in High-Dose Methamphetamine Abuse

1969 • 17 citations

The effect of typical and atypical neuroleptics on binding of [3H]spiroperidol in calf caudate.

1980 • 16 citations

Comments on "Amphetamine models of paranoid schizophrenia": A precautionary note.

1982 • 16 citations

Comments on "Amphetamine models of paranoid schizophrenia": A precautionary note.

1982 • 15 citations

An analysis of cat behavior using chlorpromazine and amphetamine

1967 • 15 citations

Typical and atypical neuroleptics are potent antagonists at ?1-adrenoceptors of the dorsal lateral geniculate nucleus

1982 • 14 citations

The effects of d-amphetamine and illumination on behaviors of the squirrel monkey

1976 • 12 citations

Amphetamine-induced stereotypy in the Mongolian gerbil (Meriones unguiculatus)

1978 • 11 citations

Structure-Activity Relationships of Several Amphetamine Drugs in Man

1977 • 9 citations

Neuroleptics and the corpus striatum: clinical implications.

1976 • 7 citations

Implications for multiple transmitter mediation of amphetamine-induced stereotypies

1982 • 6 citations