Biotin-Labeled Oligonucleotides: Enzymatic Synthesis and Use as Hybridization Probes

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Enzymatic synthesis of biotin-labeled polynucleotides: novel nucleic acid affinity probes.

1981 • 1,165 citations

Rapid and sensitive colorimetric method for visualizing biotin-labeled DNA probes hybridized to DNA or RNA immobilized on nitrocellulose: Bio-blots.

1983 • 1,075 citations

Immunological method for mapping genes on Drosophila polytene chromosomes.

1982 • 772 citations

Hybridization of synthetic oligodeoxyribonucleotides to Φ_X174 DNA: the effect of single base pair mismatch

1979 • 753 citations

Detection of viral genomes in cultured cells and paraffin-embedded tissue sections using biotin-labeled hybridization probes

1983 • 707 citations

Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides.

1983 • 536 citations

Actin gene expression visualized in chicken muscle tissue culture by using in situ hybridization with a biotinated nucleotide analog.

1982 • 295 citations

α1-Antitrypsin deficiency detection by direct analysis of the mutation in the gene

1983 • 277 citations

Oligonucleotide directed mutagenesis of the human β-globin gene: a general method for producing specific point mutations in cloned DNA

1981 • 207 citations

Prenatal Diagnosis of β-Thalassemia

1983 • 193 citations

Iminobiotin affinity columns and their application to retrieval of streptavidin.

1980 • 155 citations

Direct detection of the common Mediterranean beta-thalassemia gene with synthetic DNA probes. An alternative approach for prenatal diagnosis.

1983 • 136 citations

Allele-Specific Hybridization Using Oligonucleotide Probes of Very High Specific Activity: Discrimination of the Human β^A- and β^S-Globin Genes

1984 • 129 citations

Isolation of a cDNA clone for the murine transplantation antigen H-2Kb.

1982 • 86 citations

Electron microscopic visualization of tRNA genes with ferritin-avidin: biotin labels

1978 • 64 citations

Biotin and fluorescent labeling of RNA using T4 RNA ligase

1983 • 57 citations

Solid-phase Synthesis of Polynucleotides. VIII: A Simplified Synthesis of Oligodeoxyribonucleotides

1983 • 48 citations

Identification of the Cloned Gene for the Murine Transplantation Antigen H-2K^bby Hybridization with Synthetic Oligonucleotides

1983 • 38 citations

Gene mapping and gene enrichment by the avidin-biotin interaction: use of cytochrome-c as a polyamine bridge

1978 • 38 citations