Effect of Postoperative Analgesia on Major Postoperative Complications: A Systematic Update of the Evidence

Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised

2000 • 2,099 citations

Chronic Pain as an Outcome of Surgery

2000 • 1,343 citations

Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial

2002 • 998 citations

The Comparative Effects of Postoperative Analgesic Therapies on Pulmonary Outcome

1998 • 949 citations

Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study

2005 • 910 citations

The Comparative Effects of Postoperative Analgesic Therapies on Pulmonary Outcome

1998 • 828 citations

The Efficacy of Preemptive Analgesia for Acute Postoperative Pain Management: A Meta-Analysis

2005 • 677 citations

Does Continuous Peripheral Nerve Block Provide Superior Pain Control to Opioids? A Meta-Analysis

2005 • 672 citations

Chronic pain after surgery

2001 • 659 citations

Does Multimodal Analgesia with Acetaminophen, Nonsteroidal Antiinflammatory Drugs, or Selective Cyclooxygenase-2 Inhibitors and Patient-controlled Analgesia Morphine Offer Advantages over Morphine Alone?

2005 • 655 citations

Local Anesthetics and the Inflammatory Response

2000 • 647 citations

Risk Assessment for and Strategies To Reduce Perioperative Pulmonary Complications for Patients Undergoing Noncardiothoracic Surgery: A Guideline from the American College of Physicians

2006 • 642 citations

Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk

2005 • 631 citations

Effects of Nonsteroidal Antiinflammatory Drugs on Patient-controlled Analgesia Morphine Side Effects

2005 • 574 citations

Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestinal paralysis, PONV and pain after abdominal surgery

2001 • 528 citations

Efficacy of Continuous Wound Catheters Delivering Local Anesthetic for Postoperative Analgesia: A Quantitative and Qualitative Systematic Review of Randomized Controlled Trials

2006 • 526 citations

Epidural Analgesia Reduces Postoperative Myocardial Infarction: A Meta-Analysis

2001 • 514 citations

Efficacy of Postoperative Patient-controlled and Continuous Infusion Epidural Analgesia versus Intravenous Patient-controlled Analgesia with Opioids

2005 • 454 citations

Effect of Epidural Anesthesia and Analgesia on Perioperative Outcome

2001 • 452 citations

Functional Recovery After Open Versus Laparoscopic Colonic Resection

2005 • 439 citations

Efficacy and safety of patient‐controlled opioid analgesia for acute postoperative pain

2001 • 434 citations

Perioperative ketamine for acute postoperative pain

2006 • 425 citations

A methodological review of how heterogeneity has been examined in systematic reviews of diagnostic test accuracy

2005 • 422 citations

Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials † †Presented in part at the Annual Meeting of the Société Française d’Anesthésie-Réanimation, Paris, April 2004.

2005 • 421 citations

Delirium: a symptom of how hospital care is failing older persons and a window to improve quality of hospital care

1999 • 420 citations

Postoperative Delirium: The Importance of Pain and Pain Management

2006 • 405 citations

Perioperative Intravenous Lidocaine Has Preventive Effects on Postoperative Pain and Morphine Consumption After Major Abdominal Surgery

2004 • 360 citations

Preventing Postoperative Pulmonary Complications

2000 • 351 citations

Mechanisms of postoperative ileus

2004 • 350 citations

Effects of Perioperative Central Neuraxial Analgesia on Outcome after Coronary Artery Bypass Surgery

2004 • 349 citations

The Role of Postoperative Analgesia in Delirium and Cognitive Decline in Elderly Patients: A Systematic Review

2006 • 331 citations

Randomized clinical trial of multimodal optimization of surgical care in patients undergoing major colonic resection

2005 • 320 citations

Intravenous Lidocaine Speeds the Return of Bowel Function, Decreases Postoperative Pain, and Shortens Hospital Stay in Patients Undergoing Radical Retropubic Prostatectomy

1998 • 306 citations

The Role of Epidural Anesthesia and Analgesia in Surgical Practice

2003 • 303 citations

Towards evidence-based guidelines for the prevention of venous thromboembolism: systematic reviews of mechanical methods, oral anticoagulation, dextran and regional anaesthesia as thromboprophylaxis

2005 • 294 citations

Epidural analgesia for pain relief following hip or knee replacement

2003 • 289 citations

Prevention of Venous Thromboembolism in Surgical Patients

2004 • 275 citations

Continuous Peripheral Nerve Blocks at Home: A Review

2005 • 251 citations

The Effects of Postoperative Pain Management on Immune Response to Surgery

2003 • 249 citations

Intravenous Lidocaine Speeds the Return of Bowel Function, Decreases Postoperative Pain, and Shortens Hospital Stay in Patients Undergoing Radical Retropubic Prostatectomy

1998 • 242 citations

Patient controlled intravenous opioid analgesia versus continuous epidural analgesia for pain after intra-abdominal surgery

2013 • 230 citations

Epidural pain relief versus systemic opioid-based pain relief for abdominal aortic surgery

2006 • 225 citations

Predictors of operative mortality and cardiopulmonary morbidity in the National Emphysema Treatment Trial

2005 • 190 citations

Patient Preferences for Anesthesia Outcomes Associated with Cesarean Delivery

2005 • 176 citations

Preoperative Cardiac Events in Elderly Patients with Hip Fracture Randomized to Epidural or Conventional Analgesia

2003 • 175 citations

Perioperative Epidural Analgesia and Outcome After Major Abdominal Surgery in High-Risk Patients

2003 • 166 citations

Comparison of Morphine, Ketorolac, and Their Combination for Postoperative Pain

2005 • 162 citations

Safety and Efficacy of the Cyclooxygenase-2 Inhibitors Parecoxib and Valdecoxib after Noncardiac Surgery

2006 • 159 citations

Effect of preoperative Cox‐II‐selective NSAIDs (coxibs) on postoperative outcomes: A systematic review of randomized studies

2005 • 150 citations

Approaches to the Prevention of Perioperative Myocardial Ischemia

2000 • 146 citations

Perioperative Epidural Analgesia and Outcome After Major Abdominal Surgery in High-Risk Patients

2003 • 143 citations

Effects of Preemptive Epidural Analgesia on Post-thoracotomy Pain

2005 • 136 citations

Updates in perioperative coagulation: physiology and management of thromboembolism and haemorrhage

2004 • 136 citations

Effect of postoperative epidural analgesia on morbidity and mortality following surgery in medicare patients

2004 • 135 citations

Epidural analgesia in gastrointestinal surgery

2004 • 134 citations

Postoperative Gastrointestinal Tract Dysfunction

2004 • 132 citations

Epidural Morphine Decreases Postoperative Hypertension by Attenuating Sympathetic Nervous System Hyperactivity

1989 • 129 citations

The Effects of Continuous Epidural Anesthesia and Analgesia on Stress Response and Immune Function in Patients Undergoing Radical Esophagectomy

2005 • 118 citations

Inflammatory response after abdominal surgery

2004 • 111 citations

Perioperative β-Adrenergic Receptor Blockade

2003 • 107 citations

Effects of High Thoracic Epidural Analgesia on Myocardial Blood Flow in Patients With Ischemic Heart Disease

2005 • 102 citations

Effect of Postoperative Epidural Analgesia on Morbidity and Mortality Following Surgery in Medicare Patients

2004 • 99 citations

Underpowering in randomized trials reporting a sample size calculation

2003 • 95 citations

Thoracic Epidural Anesthesia and the Patient with Heart Disease

1997 • 95 citations

The Effects of Thoracic Epidural Analgesia with Bupivacaine 0.25% on Ventilatory Mechanics in Patients with Severe Chronic Obstructive Pulmonary Disease

2001 • 95 citations

Lung Function under High Thoracic Segmental Epidural Anesthesia with Ropivacaine or Bupivacaine in Patients with Severe Obstructive Pulmonary Disease Undergoing Breast Surgery

2002 • 88 citations

The Effects of Local Anesthetics on Perioperative Coagulation, Inflammation, and Microcirculation

2002 • 87 citations

Cardiovascular effects of two different regional anaesthetic techniques for unilateral leg surgery

1998 • 84 citations

Perioperative myocardial ischemic injury in high-risk vascular surgery patients: Incidence and clinical significance in a prospective clinical trial

2006 • 80 citations

Thoracic Epidural Anesthesia and the Patient with Heart Disease

1997 • 72 citations

The Effects of Local Anesthetics on Perioperative Coagulation, Inflammation, and Microcirculation

2002 • 72 citations

Postoperative Wound Oxygen Tension with Epidural or Intravenous Analgesia

2002 • 72 citations

Epidural Anesthesia Enhances Sympathetic Nerve Activity in the Unanesthetized Segments in Cats

1997 • 70 citations

Effect of postoperative epidural analgesia on morbidity and mortality after total hip replacement surgery in medicare patients

2003 • 59 citations

Improvement of ‘dynamic analgesia’ does not decrease atelectasis after thoracotomy

2001 • 55 citations

Epidural Anesthesia Enhances Sympathetic Nerve Activity in the Unanesthetized Segments in Cats

1997 • 48 citations

Increased risk of cardiovascular events with parecoxib/valdecoxib: a systematic review and meta-analysis.

2005 • 41 citations

Patient controlled intravenous opioid analgesia versus conventional opioid analgesia for postoperative pain control: A quantitative systematic review

2005 • 28 citations

Treatment of Inoperable Coronary Disease and Refractory Angina: Spinal Stimulators, Epidurals, Gene Therapy, Transmyocardial Laser, and Counterpulsation

2004 • 22 citations

Multivariate analysis of the risk for pulmonary complication after gastrointestinal surgery

2005 • 12 citations

[A review of clinical evidence supporting techniques to prevent chronic postoperative pain syndromes].

2004 • 9 citations

Epidural analgesia and arterial reconstructive surgery to the leg: effects on fibrinolysis and platelet degranulation

2001 • 7 citations

Use of Endoluminal Aortic Stent-Grafts for the Repair of Abdominal Aortic Aneurysms

2005 • 4 citations