Protected endogenous retroviral sequences copurify with infectivity in experimental Creutzfeldt-Jakob disease

The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis

1991 • 385 citations

The Intracisternal A-Particle Gene Family: Structure and Functional Aspects

1988 • 341 citations

Nucleotide sequence of human endogenous retrovirus genome related to the mouse mammary tumor virus genome

1986 • 334 citations

Biological Evidence that Scrapie Agent Has an Independent Genome

1987 • 320 citations

Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes

1991 • 297 citations

Isolation of cDNAs of scrapie-modulated RNAs by subtractive hybridization of a cDNA library.

1988 • 286 citations

Changes in brain gene expression shared by scrapie and Alzheimer disease.

1989 • 253 citations

SCRAPIE PRIONS

1989 • 239 citations

Pathogenesis of Scrapie (Strain 263K) in Hamsters Infected Intracerebrally, Intraperitoneally or Intraocularly

1986 • 222 citations

Dextran Sulphate 500 Delays and Prevents Mouse Scrapie by Impairment of Agent Replication in Spleen

1984 • 184 citations

Activation of the c-mos oncogene in a mouse plasmacytoma by insertion of an endogenous intracisternal A-particle genome.

1983 • 174 citations

Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulation

1992 • 155 citations

Creutzfeldt-Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes

1983 • 143 citations

Retrotransposition of a mouse IAP sequence tagged with an indicator gene

1991 • 141 citations

Viremia in Experimental Creutzfeldt-Jakob Disease

1978 • 129 citations

Detection of multiple, novel reverse transcriptase coding sequences in human nucleic acids: relation to primate retroviruses

1989 • 120 citations

Purified scrapie prions resist inactivation by UV irradiation

1987 • 118 citations

Evidence suggesting that PrP is not the infectious agent in Creutzfeldt-Jakob disease.

1987 • 116 citations

Search for a Putative Scrapie Genome in Purified Prion Fractions Reveals a Paucity of Nucleic Acids

1991 • 111 citations

Nucleotide sequence of the Syrian hamster intracisternal A-particle gene: close evolutionary relationship of type A particle gene to types B and D oncovirus genes

1985 • 110 citations

Physical properties of the Creutzfeldt-Jakob disease agent

1989 • 87 citations

Pathogenesis of Scrapie: Study of the Temporal Development of Clinical Symptoms, of Infectivity Titres and Scrapie-associated Fibrils in Brains of Hamsters Infected Intraperitoneally

1986 • 86 citations

Scrapie: Pathogenesis in Inbred Mice: An Assessment of Host Control and Response Involving Many Strains of Agent

1977 • 84 citations

Some Properties of the Scrapie Agent and Its Behavior in Mice

1963 • 82 citations

Scrapie-Infected Spleens: Analysis of Infectivity, Scrapie-Associated Fibrils, and Protease-Resistant Proteins

1991 • 80 citations

Astrocyte gene expression in Creutzfeldt-Jakob disease.

1987 • 75 citations

Integration site preferences of endogenous retroviruses

1991 • 74 citations

Sustained viremia in experimental hamster scrapie

1984 • 71 citations

Transposition of two different intracisternal A particle elements into an immunoglobulin kappa-chain gene.

1984 • 71 citations

Replication of the Scrapie Agent in Hamsters Infected Intracerebrally Confirms the Pathogenesis of an Amyloid-inducing Virosis

1988 • 70 citations

Experimental transmission of an autosomal dominant spongiform encephalopathy: does the infectious agent originate in the human genome?

1985 • 69 citations

Cloning of a Gene Whose Expression Is Increased in Scrapie and in Senile Plaques in Human Brain

1985 • 68 citations

Interspecies transmission of Creutzfeldt-Jakob disease to Syrian hamsters with reference to clinical syndromes and strains of agent.

1978 • 66 citations

Search for a Scrapie‐Specific Nucleic Acid: A Progress Report

2007 • 66 citations

A novel cDNA/PCR strategy for efficient cloning of small amounts of undefined RNA

1989 • 61 citations

Serial propagation of Creutzfeldt-Jakob disease in guinea pigs.

1976 • 60 citations

Transmission of Creutzfeldt–Jakob disease with scrapie-like syndromes to mice

1978 • 60 citations

Potential retroviral RNAs in Creutzfeldt-Jakob disease

1990 • 57 citations

Transmission studies from blood of Alzheimer disease patients and healthy relatives.

1988 • 56 citations

Presence of mitochondrial D-loop DNA in scrapie-infected brain preparations enriched for the prion protein

1990 • 54 citations

Potential Involvement of Retroviral Elements in Human Dementias

2007 • 53 citations

Creutzfeldt-Jakob Disease

1985 • 49 citations

Comparison of the sequence organization of related retrovirus-like multigene families in three evolutionary distant rodent genomes

1983 • 46 citations

Analysis of Creutzfeldt-Jakob disease infectious fractions by gel permeation chromatography and sedimentation field flow fractionation

1992 • 44 citations

The Reticuloendothelial System in Scrapie Pathogenesis

1984 • 43 citations

Nuclease-resistant polyadenylated RNAs of significant size are detected by PCR in highly purified Creutzfeldt-Jakob disease preparations

1990 • 42 citations

Amyloid plaques in the brains of mice with Creutzfeldt–Jakob disease

1984 • 40 citations

Isolation and partial characterization of the internal structural proteins from murine intracisternal A particles

1973 • 36 citations

Nuclease treatment results in high specific purification of Creutzfeldt-Jakob disease infectivity with a density characteristic of nucleic acid-protein complexes

1990 • 35 citations

Transmission of Alpers' disease (chronic progressive encephalopathy) produces experimental Creutzfeldt‐Jakob disease in hamsters

1989 • 34 citations

Transposition of Two Different Intracisternal A Particle Elements into an Immunoglobulin Kappa-Chain Gene

1984 • 34 citations

SUGGESTED LINKS BETWEEN DIFFERENT TYPES OF DEMENTIAS

1989 • 30 citations

Immortality of cell cultures derived from brains of mice and hamsters infected with Creutzfeldt-Jakob disease agent.

1987 • 29 citations

In vitro Transformation Elicited by Creutzfeldt-Jakob-Infected Brain Material

1986 • 23 citations

Search for a Transmissible Agent in Alzheimer’s Disease: Studies of Human Buffy Coat

1991 • 10 citations

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