Hyaluronan Enters Keratinocytes by a Novel Endocytic Route for Catabolism

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan

1999 • 1,519 citations

A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.

1996 • 946 citations

Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules.

1994 • 894 citations

Hyaluronan Synthases

1997 • 599 citations

β-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the golgi complex, shows homology to β-adaptin

1991 • 489 citations

Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of 125I-asialofetuin by the perfused rat liver.

1980 • 451 citations

Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells [published erratum appears in J Cell Biol 1990 Mar;110(3):859]

1989 • 448 citations

Hyaluronan Binding by Cell Surface CD44

2000 • 406 citations

The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronan.

1992 • 399 citations

Analysis of Cd44-Containing Lipid Rafts

1999 • 399 citations

Hyaluronan Binding by Cell Surface CD44

2000 • 362 citations

Localization of inositol 1,4,5-trisphosphate receptor-like protein in plasmalemmal caveolae.

1992 • 345 citations

Intracellular routing of transferrin and transferrin receptors in epidermoid carcinoma A431 cells

1983 • 330 citations

HYAL2, a Human Gene Expressed in Many Cells, Encodes a Lysosomal Hyaluronidase with a Novel Type of Specificity

1998 • 295 citations

Studies in vitro on the uptake and degradation of sodium hyaluronate in rat liver endothelial cells

1984 • 293 citations

Hyaluronan receptor-directed assembly of chondrocyte pericellular matrix.

1993 • 282 citations

Internalization of hyaluronan by chondrocytes occurs via receptor-mediated endocytosis

1993 • 282 citations

Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation.

1997 • 270 citations

Identification of the Hyaluronan Receptor for Endocytosis (HARE)

2000 • 255 citations

Intracellular Localization of Hyaluronan in Proliferating Cells

1999 • 226 citations

Membrane Expansion Increases Endocytosis Rate during Mitosis

1999 • 217 citations

The hyaluronic acid binding region as a specific probe for the localization of hyaluronic acid in tissue sections. Application to chick embryo and rat brain.

1985 • 206 citations

Microanalysis of enzyme digests of hyaluronan and chondroitin/dermatan sulfate by fluorophore-assisted carbohydrate electrophoresis (FACE)

2000 • 203 citations

Preparation and properties of fluorescein-labelled hyaluronate

1975 • 197 citations

Epidermal Growth Factor Activates Hyaluronan Synthase 2 in Epidermal Keratinocytes and Increases Pericellular and Intracellular Hyaluronan

2001 • 194 citations

CD44-Anchored Hyaluronan-Rich Pericellular Matrices: An Ultrastructural and Biochemical Analysis

1996 • 191 citations

Endocytosis: what goes in and how?

1992 • 177 citations

Uptake of circulating hyaluronic acid by the rat liver

1985 • 169 citations

Uptake and degradation of hyaluronan in lymphatic tissue

1988 • 165 citations

Binding and degradation of hyaluronan by human breast cancer cell lines expressing different forms of CD44: Correlation with invasive potential

1994 • 165 citations

Binding of hyaluronate and chondroitin sulphate to liver endothelial cells

1986 • 159 citations

Hyaluronan Metabolism in Skin

1994 • 155 citations

Degradation of Newly Synthesized High Molecular Mass Hyaluronan in the Epidermal and Dermal Compartments of Human Skin in Organ Culture

1991 • 151 citations

Circular ruffle formation and closure lead to macropinocytosis in hepatocyte growth factor/scatter factor-treated cells.

1993 • 145 citations

Regulated clustering of variant CD44 proteins increases their hyaluronate binding capacity.

1996 • 144 citations

CD44 Positive Macrophages Take up Hyaluronan during Lung Development

1993 • 142 citations

Endocytosis of hyaluronic acid by rat liver endothelial cells. Evidence for receptor recycling

1989 • 141 citations

Effects of detergent solubilization on the hyaluronate-binding protein from membranes of simian virus 40-transformed 3T3 cells.

1983 • 141 citations

Hyaluronan Bound to CD44 on Keratinocytes Is Displaced by Hyaluronan Decasaccharides and Not Hexasaccharides

1998 • 138 citations

Structure-activity studies of flavonoids as inhibitors of hyaluronidase

1990 • 123 citations

Antibody‐induced activation of the hyaluronan receptor function of CD44 requires multivalent binding by antibody

1993 • 120 citations

Role of CD44 cytoplasmic domain in hyaluronan binding

1995 • 119 citations

Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action

1998 • 112 citations

Internalization of the Hyaluronan Receptor CD44 by Chondrocytes

1999 • 96 citations

The Growth and Differentiation of Cultured Newborn Rat Keratinocytes

1983 • 95 citations

Hyperosmolarity inhibits galactosyl receptor-mediated but not fluid phase endocytosis in isolated rat hepatocytes

1989 • 94 citations

Catabolism of hyaluronan in rabbit skin takes place locally, in lymph nodes and liver

1991 • 90 citations

Catabolism of Hyaluronan in the Knee Joint of the Rabbit

1992 • 73 citations

Size‐dependent hyaluronate degradation by cultured cells

1987 • 69 citations

Glycosylphosphatidylinositol-anchored and core protein-intercalated heparan sulfate proteoglycans in rat ovarian granulosa cells have distinct secretory, endocytotic, and intracellular degradative pathways.

1992 • 62 citations

A preformed basal lamina alters the metabolism and distribution of hyaluronan in epidermal keratinocyte "organotypic" cultures grown on collagen matrices

2000 • 60 citations

Hyaluronan receptor (CD44) expression and function in human peripheral blood monocytes and alveolar macrophages

1994 • 59 citations

Optimal techniques for the immunocytochemical demonstration of?-thromboglobulin, platelet factor 4, and fibrinogen in the alpha granules of unstimulated platelets

1984 • 51 citations

Hydrocortisone regulation of hyaluronan metabolism in human skin organ culture

1995 • 51 citations

[36] Specific activity of radiolabeled hexosamines in metabolic labeling experiments

1989 • 51 citations

Influence of retinoic acid on the ultrastructure and hyaluronic acid synthesis of adult human epidermis in whole skin organ culture

1986 • 45 citations

Hyaluronidase activity of macaque sperm assessed by an in vitro cumulus penetration assay

1997 • 32 citations

Endocytosis of desmosomal plaques depends on intact actin filaments and leads to a nondegradative compartment.

1993 • 32 citations

Internalization of type 1 complement receptors and de novo multivesicular body formation during chemoattractant-induced endocytosis in human neutrophils.

1994 • 32 citations

Histochemistry and ultrastructure of adrenergic and acetylcholinesterase-containing nerves supplying follicles and endocrine cells in the guinea-pig ovary

1985 • 29 citations

Specific internalization of basal membrane domains containing the integrin alpha 6 beta 4 in dispase-detached cultured human keratinocytes.

1993 • 27 citations

Evidence for Autoregulation of Cell Division and Cell Transit in Keratinocytes Grown on Collagen at an Air-Liquid Interface

1990 • 26 citations

CD44 Substituted with Heparan Sulfate and Endo-β-galactosidase-Sensitive Oligosaccharides: A Major Proteoglycan in Adult Human Epidermis

1997 • 25 citations

Caveolin-1 and -2 Expression Is Differentially Regulated in Cultured Keratinocytes and within the Regenerating Epidermis of Cutaneous Wounds

2000 • 22 citations

Difference of Hyaluronidase Produced by Human Tumor Cell Lines with Hyaluronidase Present in Human Serum as Revealed by Zymography

1997 • 21 citations

Detergent solubilization of the endocytic calcium-independent hyaluronan receptor from rat liver endothelial cells and separation from a calcium-dependent hyaluronan-binding activity

1992 • 19 citations

Three Unrelated Perturbations Similarly Uncouple Fluid, Bulk-Membrane, and Receptor Endosomal Flow in Rat Fetal Fibroblasts

1997 • 15 citations