Core candidate neurochemical and imaging biomarkers of Alzheimer's disease

Voxel-Based Morphometry—The Methods

2000 • 8,281 citations

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

2004 • 4,223 citations

Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI

2004 • 3,544 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

A New Rating Scale for Age-Related White Matter Changes Applicable to MRI and CT

2001 • 1,674 citations

Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study

2006 • 1,661 citations

Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment

1999 • 1,384 citations

CSF markers for incipient Alzheimer's disease

2003 • 1,257 citations

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ₄₂ in humans

2005 • 1,216 citations

Alzheimer’s Dementia

1985 • 1,042 citations

Cerebrospinal Fluid tau/β-Amyloid42 Ratio as a Prediction of Cognitive Decline in Nondemented Older Adults

2007 • 869 citations

Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study

2005 • 731 citations

Improved discrimination of AD patients using β-amyloid _(1-42) and tau levels in CSF

1999 • 709 citations

Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease

2001 • 706 citations

Alterations in Memory Networks in Mild Cognitive Impairment and Alzheimer's Disease: An Independent Component Analysis

2006 • 688 citations

In Vivo Mapping of Gray Matter Loss with Voxel-Based Morphometry in Mild Alzheimer's Disease

2001 • 664 citations

Consensus Report of the Working Group on: “Molecular and Biochemical Markers of Alzheimer’s Disease”

1998 • 651 citations

Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease

1998 • 630 citations

Hippocampus and entorhinal cortex in mild cognitive impairment and early AD

2003 • 617 citations

Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease

2004 • 585 citations

CSF Aβ 42 levels correlate with amyloid-neuropathology in a population-based autopsy study

2003 • 585 citations

CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease

2006 • 571 citations

Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease

2005 • 543 citations

Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: A longitudinal MRI study

2005 • 533 citations

Pathologic Correlates of Nondemented Aging, Mild Cognitive Impairment, and Early-Stage Alzheimer's Disease

2001 • 521 citations

Plasma Aβ1–40 and Aβ1–42 and the risk of dementia: a prospective case-cohort study

2006 • 446 citations

Focal Decline of Cortical Thickness in Alzheimer's Disease Identified by Computational Neuroanatomy

2004 • 427 citations

Plasma Aβ40 and Aβ42 and Alzheimer’s disease

2003 • 425 citations

Association of Low Plasma Aβ42/Aβ40 Ratios With Increased Imminent Risk for Mild Cognitive Impairment and Alzheimer Disease

2007 • 424 citations

Tau and Aβ42 in Cerebrospinal Fluid from Healthy Adults 21–93 Years of Age: Establishment of Reference Values

2001 • 421 citations

Measurement of Phosphorylated Tau Epitopes in the Differential Diagnosisof Alzheimer Disease

2004 • 419 citations

Differential aging of the medial temporal lobe

2004 • 415 citations

Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment

2002 • 363 citations

Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD

2000 • 320 citations

Preclinical detection of Alzheimer's disease: hippocampal shape and volume predict dementia onset in the elderly

2005 • 319 citations

Standardization of measurement of β-amyloid_(1-42)in cerebrospinal fluid and plasma

2000 • 301 citations

Value of CSF β-amyloid1–42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment

2003 • 297 citations

Differential Diagnosis of Alzheimer Disease With Cerebrospinal Fluid Levels of Tau Protein Phosphorylated at Threonine 231

2002 • 275 citations

Automated cortical thickness measurements from MRI can accurately separate Alzheimer's patients from normal elderly controls

2006 • 268 citations

Biomarkers of Alzheimer disease in plasma

2004 • 268 citations

Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment

2005 • 257 citations

Biological markers for therapeutic trials in Alzheimer’s disease

2003 • 256 citations

CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects

2002 • 248 citations

Fluctuations of CSF amyloid-β levels

2007 • 247 citations

Amyloid β peptide ratio 42/40 but not Aβ42 correlates with phospho‐Tau in patients with low‐ and high‐CSF Aβ40 load

2006 • 246 citations

Functional connectivity of the fusiform gyrus during a face-matching task in subjects with mild cognitive impairment

2006 • 246 citations

Measurement of basal forebrain atrophy in Alzheimer's disease using MRI

2005 • 237 citations

Amyloid β protein 1–40 and 1–42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease

2001 • 226 citations

A voxel based morphometry study on mild cognitive impairment

2004 • 221 citations

A voxel-based morphometry study of temporal lobe gray matter reductions in Alzheimer’s disease

2002 • 219 citations

White Matter Damage in Alzheimer Disease and Mild Cognitive Impairment: Assessment with Diffusion-Tensor MR Imaging and Parallel Imaging Techniques

2007 • 213 citations

Comparison of automated and manual MRI volumetry of hippocampus in normal aging and dementia

2002 • 210 citations

Volumes of Medial Temporal Lobe Structures in Patients with Alzheimer’s Disease and Mild Cognitive Impairment (and in Healthy Controls)

1998 • 210 citations

Levels of β-Secretase (BACE1) in Cerebrospinal Fluid as a Predictor of Risk in Mild Cognitive Impairment

2007 • 202 citations

Multivariate deformation-based analysis of brain atrophy to predict Alzheimer's disease in mild cognitive impairment

2007 • 200 citations

High Levels of Circulating Aβ42 Are Sequestered by Plasma Proteins in Alzheimer's Disease

1999 • 183 citations

CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment

2006 • 179 citations

Multivariate network analysis of fiber tract integrity in Alzheimer’s disease

2006 • 175 citations

Correlation of Cerebrospinal Fluid Levels of Tau Protein Phosphorylated at Threonine 231 With Rates of Hippocampal Atrophy in Alzheimer Disease

2005 • 171 citations

Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease

2005 • 162 citations

Brain metabolic and clinical effects of rivastigmine in Alzheimer's disease

2001 • 156 citations

Age‐related cortical grey matter reductions in non‐demented Down’s syndrome adults determined by MRI with voxel‐based morphometry

2004 • 149 citations

Multicenter assessment of CSF-phosphorylated tau for the prediction of conversion of MCI

2007 • 142 citations

In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease

2003 • 135 citations

Neuroanatomy of Down Syndrome in vivo: A Model of Preclinical Alzheimer’s Disease

2006 • 132 citations

Cerebrospinal fluid tau, phospho‐tau₁₈₁ and β‐amyloid₁₋₄₂ in idiopathic normal pressure hydrocephalus: a discrimination from Alzheimer's disease

2007 • 126 citations

Hippocampus in Alzheimer’s disease: a 3-year follow-up MRI study

2000 • 124 citations

An Alzheimer's disease-specific β-amyloid fragment signature in cerebrospinal fluid

2006 • 122 citations

Comprehensive dissection of the medial temporal lobe in AD: measurement of hippocampus, amygdala, entorhinal, perirhinal and parahippocampal cortices using MRI

2006 • 117 citations

Differentiation of Alzheimer's disease from dementia with Lewy bodies utilizing positron emission tomography with [18F]fluorodeoxyglucose and neuropsychological testing

2004 • 111 citations

Predictors of Conversion to Dementia of Probable Alzheimer Type in Patients with Mild Cognitive Impairment

2006 • 108 citations

Investigating the neural basis for functional and effective connectivity. Application to fMRI

2005 • 106 citations

Multicenter assessment of reliability of cranial MRI

2005 • 99 citations

Cerebrospinal Fluid Amyloid ss42/Phosphorylated Tau Ratio Discriminates Between Alzheimer's Disease and Vascular Dementia

2006 • 98 citations

Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: A multicenter study

2007 • 98 citations

Back to the future: the 'old-fashioned' way to new medications for neurodegeneration

2004 • 87 citations

Fiber Connections between the Cerebral Cortex and the Corpus Callosum in Alzheimer's Disease: A Diffusion Tensor Imaging and Voxel-Based Morphometry Study

2006 • 87 citations

Selective Reductions in Plasma A 1-42 in Healthy Elderly Subjects During Longitudinal Follow-Up: A Preliminary Report

2005 • 86 citations

?-amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease

2003 • 84 citations

Combined rCBF and CSF biomarkers predict progression from mild cognitive impairment to Alzheimer's disease

2007 • 80 citations

Effects of donepezil on cortical metabolic response to activation during 18FDG-PET in Alzheimer’s disease: a double-blind cross-over trial

2006 • 74 citations

Prediction of Alzheimer's disease in mild cognitive impairment: A prospective study in Taiwan

2005 • 74 citations

Plasma Aβ Levels Do Not Reflect Brain Aβ Levels

2007 • 69 citations

Cerebrospinal fluid tau protein shows a better discrimination in young old (<70 years) than in old old patients with Alzheimer's disease compared with controls

1999 • 66 citations

Imaging Alzheimer's disease: clinical applications

2003 • 66 citations

Phosphorylated tau predicts rate of cognitive decline in MCI subjects: A comparative CSF study

2005 • 64 citations

Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease.

1990 • 64 citations

Evidence of amyloid beta-protein immunoreactive early plaque lesions in Down's syndrome brains.

1989 • 63 citations

Morphological substrate of face matching in healthy ageing and mild cognitive impairment: a combined MRI-fMRI study

2007 • 53 citations

Biochemistry and molecular biology of tauopathies

2006 • 52 citations

Imaging of Muscarinic Receptors in the Central Nervous System

2006 • 39 citations

CSF phosphorylated tau—does it constitute an accurate biological test for Alzheimer's disease?

2003 • 32 citations

Klinische Wertigkeit der Positronen-Emissions-Tomographie in der Neuromedizin Positionspapier zu den Ergebnissen einer interdisziplinären Konsensuskonferenz

1998 • 21 citations

Selective Reductions in Plasma Aβ 1-42 in Healthy Elderly Subjects During Longitudinal Follow-Up: A Preliminary Report

2005 • 17 citations

Response to Boban et al: computer-assisted 3D reconstruction of the nucleus basalis complex, including the nucleus subputaminalis (Ayala's nucleus)

2006 • 16 citations