Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform.

Molecular Biology of Prion Diseases

1991 • 1,978 citations

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

1992 • 1,632 citations

A cellular gene encodes scrapie PrP 27-30 protein

1985 • 1,494 citations

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

1990 • 874 citations

Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins

1987 • 757 citations

Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques

1989 • 696 citations

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

1991 • 627 citations

Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.

1990 • 510 citations

Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain

1985 • 490 citations

The sequential development of the brain lesions of scrapie in three strains of mice

1968 • 463 citations

Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent

1992 • 440 citations

Identification of a gene which controls the incubation period of some strains of scrapie agent in mice

1968 • 425 citations

Scrapie prion proteins are synthesized in neurons.

1986 • 422 citations

Linkage of prion protein and scrapie incubation time genes

1986 • 405 citations

Scrapie in mice

1973 • 340 citations

Regional mapping of prion proteins in brain.

1992 • 329 citations

Characteristics of a Short Incubation Model of Scrapie in the Golden Hamster

1977 • 310 citations

Synthesis and trafficking of prion proteins in cultured cells.

1992 • 268 citations

Changes in the localization of brain prion proteins during scrapie infection

1987 • 268 citations

Temporary and Permanent Modifications to a Single Strain of Mouse Scrapie on Transmission to Rats and Hamsters

1987 • 240 citations

Prion diseases of humans and animals

1996 • 238 citations

The Genomic Identity of Different Strains of Mouse Scrapie Is Expressed in Hamsters and Preserved on Reisolation in Mice

1989 • 222 citations

Rapid detection of Creutzfeldt‐Jakob disease and scrapie prion proteins

1990 • 217 citations

Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.

1992 • 213 citations

Scrapie Produced Experimentally in Goats With Special Reference To the Clinical Syndrome

1961 • 198 citations

Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation.

1990 • 170 citations

Proteinase‐resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity

1991 • 167 citations

Linkage of the Scrapie-associated Fibril Protein (PrP) Gene and Sinc Using Congenic Mice and Restriction Fragment Length Polymorphism Analysis

1987 • 159 citations

Comparison of Scrapie and Transmissible Mink Encephalopathy in Hamsters. II. Clinical Signs, Pathology, and Pathogenesis

1975 • 159 citations

Viroids and prions.

1982 • 145 citations

A comparison of some biological characteristics of the mouse-passaged scrapie agents, 22A and ME7

1969 • 136 citations

Further analysis of nucleic acids in purified scrapie prion preparations by improved return refocusing gel electrophoresis

1992 • 131 citations

Monoclonal Antibodies to the Cellular and Scrapie Prion Proteins

1986 • 127 citations

Purified scrapie prions resist inactivation by UV irradiation

1987 • 118 citations

Epitope mapping of the Syrian hamster prion protein utilizing chimeric and mutant genes in a vaccinia virus expression system.

1991 • 107 citations

Chemistry and biology of prions

1992 • 106 citations

Purified scrapie prions resist inactivation by procedures that hydrolyze, modify, or shear nucleic acids

1987 • 89 citations

Reversible Chemical Modification of the Scrapie Agent

1981 • 76 citations

Analysis of linkage between scrapie incubation period and the prion protein gene in mice

1990 • 64 citations

Human alpha 2(VI) collagen gene. Heterogeneity at the 5'-untranslated region generated by an alternate exon.

1992 • 55 citations

The search for scrapie agent nucleic acid

1990 • 43 citations

Spread of scrapie by contact in mice

1968 • 14 citations