Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Cytokines and acute neurodegeneration

2001 • 1,095 citations

NF-kB: a crucial transcription factor for glial and neuronal cell function

1997 • 1,005 citations

Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics

1999 • 928 citations

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

1999 • 881 citations

Central nervous system injury-induced immune deficiency syndrome

2005 • 856 citations

Stroke-induced Immunodeficiency Promotes Spontaneous Bacterial Infections and Is Mediated by Sympathetic Activation Reversal by Poststroke T Helper Cell Type 1–like Immunostimulation

2003 • 838 citations

Tumor necrosis factor-alpha expression in ischemic neurons.

1994 • 793 citations

Role of T Lymphocytes and Interferon-γ in Ischemic Stroke

2006 • 659 citations

Experimental Stroke Induces Massive, Rapid Activation of the Peripheral Immune System

2005 • 511 citations

Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases

2004 • 487 citations

Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

2004 • 454 citations

Stroke-Induced Immunodepression

2007 • 427 citations

Splenic Atrophy in Experimental Stroke Is Accompanied by Increased Regulatory T Cells and Circulating Macrophages

2006 • 382 citations

Passive or Active Immunization with Myelin Basic Protein Promotes Recovery from Spinal Cord Contusion

2000 • 368 citations

Infection After Acute Ischemic Stroke

2007 • 357 citations

Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo.

2001 • 352 citations

T- and B-Cell-Deficient Mice with Experimental Stroke have Reduced Lesion Size and Inflammation

2007 • 351 citations

Interleukin-1 beta mRNA expression in ischemic rat cortex.

1993 • 335 citations

Inflammation in central nervous system injury

2003 • 329 citations

The role of different subsets of T regulatory cells in controlling autoimmunity

2000 • 323 citations

An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis

2003 • 290 citations

Control of immune pathology by regulatory T cells

1998 • 289 citations

Post-ischemic inflammation: molecular mechanisms and therapeutic implications

2004 • 289 citations

Lymphocytic Infiltration and Expression of Intercellular Adhesion Molecule-1 in Photochemically Induced Ischemia of the Rat Cortex

1995 • 286 citations

Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat

1995 • 283 citations

Concomitant cortical expression of TNF-α and IL-1β mRNAs follows early response gene expression in transient focal ischemia

1994 • 278 citations

Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion

1994 • 268 citations

The spleen contributes to stroke‐induced neurodegeneration

2008 • 262 citations

Neuroprotective autoimmunity: Naturally occurring CD4 ⁺ CD25 ⁺ regulatory T cells suppress the ability to withstand injury to the central nervous system

2002 • 261 citations

Lateralization in autononic dysfunction in ischemic stroke involving the insular cortex

2004 • 260 citations

Regulatory T cells in autoimmunity

2007 • 228 citations

Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of treg cells, and enhanced expression of the PD-1 costimulatory pathway

2006 • 225 citations

Cellular Immunodepression Preceding Infectious Complications after Acute Ischemic Stroke in Humans

2007 • 212 citations

IFN-γ Production by Th1 Cells Generated from Naive CD4+ T Cells Exposed to Norepinephrine

2001 • 200 citations

Monocyte Chemoattractant Protein–1 Messenger RNA Expression in Rat Ischemic Cortex

1995 • 198 citations

Regulatory T Cells in Immunologic Self-Tolerance and Autoimmune Disease

2005 • 198 citations

Desferrioxamine Induces Delayed Tolerance against Cerebral Ischemiain Vivoandin Vitro

2002 • 187 citations

The use of flow cytometry to evaluate temporal changes in inflammatory cells following focal cerebral ischemia in mice

2002 • 186 citations

Lack of Interleukin-6 Expression Is Not Protective Against Focal Central Nervous System Ischemia

2000 • 179 citations

Expression of Interleukin-6, c-Fos, and zif268 mRNAs in Rat Ischemic Cortex

1995 • 179 citations

Antibody to the α4 Integrin Decreases Infarct Size in Transient Focal Cerebral Ischemia in Rats

2001 • 161 citations

Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia

1997 • 153 citations

Interleukin-1 Receptor and Receptor Antagonist Gene Expression After Focal Stroke in Rats

1997 • 148 citations

Inflammation After Stroke

2001 • 134 citations

Prolonged Expression of Interferon‐Inducible Protein‐10 in Ischemic Cortex After Permanent Occlusion of the Middle Cerebral Artery in Rat

1998 • 108 citations

Inhibition of α4 Integrin Protects Against Transient Focal Cerebral Ischemia in Normotensive and Hypertensive Rats

2001 • 90 citations

Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production

2007 • 84 citations

Temporal effects of left versus right middle cerebral artery occlusion on spleen lymphocyte subsets and mitogenic response in Wistar rats

2002 • 84 citations

Elevated pro-inflammatory CD4 ⁺ CD28 ⁻ lymphocytes and stroke recurrence and death

2004 • 80 citations

Chemokine Receptor Antagonist Peptide, Viral MIP-II, Protects the Brain against Focal Cerebral Ischemia in Mice

2001 • 77 citations

Identification and molecular characterization of rat CXCR3: receptor expression and interferon-inducible protein-10 binding are increased in focal stroke.

2000 • 75 citations

Tumor Necrosis Factor-α Expression in Ischemic Neurons

2000 • 67 citations

Cloning of rat HIV-1-chemokine coreceptor CKR5 from microglia and upregulation of its mRNA in ischemic and endotoxinemic rat brain

1998 • 45 citations

TAK-779, A Nonpeptide CC Chemokine Receptor Antagonist, Protects the Brain against Focal Cerebral Ischemia in Mice

2002 • 41 citations

Inflammatory cytokines in the nervous system: multifunctional mediators in autoimmunity and cerebral ischemia.

2002 • 33 citations

Interleukin-6 receptor expression and localization after transient global ischemia in gerbil hippocampus

2003 • 20 citations