Expression, purification and characterization of a 41 kDa insulin receptor tyrosine kinase domain

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

After Insulin Binds

1987 • 687 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.

1988 • 467 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.

1984 • 299 citations

Identification of insulin receptor tyrosine residues autophosphorylated in vitro.

1987 • 182 citations

The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation.

1987 • 179 citations

An endogenous substrate for the insulin receptor-associated tyrosine kinase.

1985 • 168 citations

Autophosphorylation of the insulin receptor in vitro. Designation of phosphorylation sites and correlation with receptor kinase activation.

1986 • 158 citations

Synthesis, purification, and characterization of the cytoplasmic domain of the human insulin receptor using a baculovirus expression system.

1988 • 120 citations

Relationship of site-specific beta subunit tyrosine autophosphorylation to insulin activation of the insulin receptor (tyrosine) protein kinase activity.

1988 • 103 citations

Effect of vanadate on the cellular accumulation of pp15, an apparent product of insulin receptor tyrosine kinase action.

1988 • 103 citations

Lipocortins 1 and 2 as substrates for the insulin receptor kinase in rat liver.

1988 • 79 citations

Separate domains of the insulin receptor contain sites of autophosphorylation and tyrosine kinase activity

1987 • 66 citations

Two systems in vitro that show insulin-stimulated serine kinase activity towards the insulin receptor

1988 • 59 citations

Kinetic properties of the insulin receptor tyrosine protein kinase: Activation through an insulin-stimulated tyrosine-specific, intramolecular autophosphorylation

1986 • 57 citations

Requirement for receptor-intrinsic tyrosine kinase activities during ligand-induced membrane ruffling of KB cells. Essential sites of src-related growth factor receptor kinases.

1988 • 48 citations

Purification and characterization of protein phosphatase 1I activating kinase from bovine brain cytosolic and particulate fractions

1989 • 37 citations