Antiangiogenic therapy and tumor progression

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Targeting HIF-1 for cancer therapy

2003 • 6,321 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

Hypoxia — a key regulatory factor in tumour growth

2002 • 4,942 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

2001 • 2,558 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy

2001 • 2,069 citations

HIF-1alpha is required for solid tumor formation and embryonic vascularization

1998 • 1,567 citations

Clinical translation of angiogenesis inhibitors

2002 • 1,518 citations

The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

1998 • 1,506 citations

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

2003 • 1,276 citations

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1996 • 1,195 citations

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

2000 • 1,159 citations

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

2003 • 1,056 citations

HIF-1 and tumor progression: pathophysiology and therapeutics

2002 • 1,025 citations

Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL

2003 • 864 citations

Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival

2001 • 752 citations

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF

2003 • 713 citations

HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

2001 • 688 citations

Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.

2003 • 617 citations

HIF-1 as a target for drug development

2003 • 607 citations

Expression of hypoxia-inducible factor 1? in brain tumors

2000 • 596 citations

Hypoxia-Inducible Factor 1α Is Essential for Cell Cycle Arrest during Hypoxia

2002 • 508 citations

Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.

2002 • 448 citations

A role for survivin in chemoresistance of endothelial cells mediated by VEGF

2002 • 438 citations

Effect of p53 Status on Tumor Response to Antiangiogenic Therapy

2002 • 427 citations

Angiogenesis and apoptosis

2003 • 419 citations

Direct protein–protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans

2000 • 397 citations

Targeting gene expression to hypoxic tumor cells

1997 • 373 citations

Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells.

2003 • 340 citations

Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation.

2001 • 329 citations

Hypoxic cervical cancers with low apoptotic index are highly aggressive.

1999 • 328 citations

HIF hydroxylation and the mammalian oxygen-sensing pathway

2003 • 313 citations

Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.

2002 • 296 citations

Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1

2000 • 294 citations

Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors.

2001 • 294 citations

HIF hydroxylation and the mammalian oxygen-sensing pathway

2003 • 288 citations

Perspectives on the development of a molecularly targeted agent

2002 • 267 citations

Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts.

2002 • 241 citations

Hypoxia-Inducible Factor-1 (HIF-1) Up-Regulates Adrenomedullin Expression in Human Tumor Cell Lines during Oxygen Deprivation: A Possible Promotion Mechanism of Carcinogenesis

2000 • 236 citations

Regression of established tumors and metastases by potent vascular endothelial growth factor blockade

2003 • 227 citations

Multilineage embryonic hematopoiesis requires hypoxic ARNT activity

1999 • 188 citations

Anoxic induction of ATF-4 through HIF-1–independent pathways of protein stabilization in human cancer cells

2003 • 173 citations

Out of air is not out of action

2003 • 162 citations

Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor.

2002 • 155 citations

How oxygen makes its presence felt: Figure 1.

2002 • 149 citations

Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions.

1997 • 147 citations

Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy.

2000 • 127 citations

Tirapazamine: a hypoxia-activated topoisomerase II poison.

2002 • 121 citations

Hypoxia-inducible Factor-2α (HIF-2α) Is Involved in the Apoptotic Response to Hypoglycemia but Not to Hypoxia

2001 • 115 citations

Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor.

2000 • 110 citations

Oncogenic resistance to growth-limiting conditions

2002 • 93 citations

Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy (Review)

2001 • 91 citations

Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors

2003 • 87 citations

Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer.

2000 • 84 citations

Angiogenesis inhibitors: motivators of metastasis?

2003 • 79 citations

Disabling Abl—Perspectives on Abl kinase regulation and cancer therapeutics

2002 • 52 citations

Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinoma.

2003 • 48 citations

Time to second prostate-specific antigen failure is a surrogate endpoint for prostate cancer death in a prospective trial of therapy for localized disease

1996 • 42 citations

Benign-to-Malignant B16 melanoma Progression Induced in Two Stages In Vitro by Exposure to Hypoxi

1994 • 41 citations

The role of radioactive iodine in the treatment of advanced differentiated thyroid carcinoma

1997 • 31 citations

Dead Cells Don’t Form Tumors: HIF-Dependent Cytotoxins

2004 • 15 citations

Hypoxia-inducible Factor-1

2013 • 1 citations