Mapping Quantitative Trait Loci for Vertebral Trabecular Bone Volume Fraction and Microarchitecture in Mice

Initial sequencing and comparative analysis of the mouse genome

2002 • 6,971 citations

Osteoporosis Prevention, Diagnosis, and Therapy

2001 • 5,052 citations

A new method for the model‐independent assessment of thickness in three‐dimensional images

1997 • 1,675 citations

Direct Three-Dimensional Morphometric Analysis of Human Cancellous Bone: Microstructural Data from Spine, Femur, Iliac Crest, and Calcaneus

1999 • 1,279 citations

Quantification of Bone Microarchitecture with the Structure Model Index

1997 • 1,030 citations

Multiple Interval Mapping for Quantitative Trait Loci

1999 • 966 citations

A microtomographic system for the nondestructive evaluation of bone architecture

1996 • 885 citations

Interval mapping of multiple quantitative trait loci.

1993 • 867 citations

A comprehensive genetic map of the mouse genome

1996 • 844 citations

Three-dimensional methods for quantification of cancellous bone architecture

1997 • 749 citations

A Statistical Framework for Quantitative Trait Mapping

2001 • 632 citations

Genetic variability in adult bone density among inbred strains of mice

1996 • 630 citations

Fallacy of Per-Weight and Per-Surface Area Standards, and Their Relation to Spurious Correlation

1949 • 514 citations

A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality

2001 • 454 citations

Genetics of Osteoporosis

2002 • 448 citations

Trabecular Bone Microarchitecture, Bone Mineral Density, and Vertebral Fractures in Male Osteoporosis

2000 • 371 citations

The relative contribution of trabecular and cortical bone to the strength of human lumbar vertebrae

1969 • 370 citations

Genetics of Osteoporosis

1999 • 370 citations

Statistical Methods for Mapping Quantitative Trait Loci From a Dense Set of Markers

1999 • 311 citations

Stress distributions within the proximal femur during gait and falls: Implications for osteoporotic fracture

1995 • 303 citations

Variations in Three-Dimensional Cancellous Bone Architecture of the Proximal Femur in Female Hip Fractures and in Controls

2000 • 289 citations

Changes in Bone Structure and Mass With Advancing Age in the Male C57BL/6J Mouse

2002 • 285 citations

Sex differences in age-related changes in vertebral body size, density and biomechanical competence in normal individuals

1990 • 272 citations

Quantitative Trait Loci for Femoral and Lumbar Vertebral Bone Mineral Density in C57BL/6J and C3H/HeJ Inbred Strains of Mice

2001 • 258 citations

Genetic Factors in Bone Turnover*

1991 • 240 citations

Role of genetic factors in the pathogenesis of osteoporosis

2000 • 225 citations

First-stage autosomal genome screen in extended pedigrees suggests genes predisposing to low bone mineral density on chromosomes 1p, 2p and 4q

1998 • 222 citations

Quantitative Trait Loci Affecting Peak Bone Mineral Density in Mice

1998 • 215 citations

Gender Specificity in the Genetic Determinants of Peak Bone Mass

2001 • 201 citations

Genetic Regulation of Cortical and Trabecular Bone Strength and Microstructure in Inbred Strains of Mice

2000 • 200 citations

Genome Screen for QTLs Contributing to Normal Variation in Bone Mineral Density and Osteoporosis*

2000 • 199 citations

Load Sharing Between the Shell and Centrum in the Lumbar Vertebral Body

1997 • 192 citations

Circulating and skeletal insulin-like growth factor-I (IGF-i) concentrations in two inbred strains of mice with different bone mineral densities

1997 • 174 citations

Cancellous bone mechanical properties from normals and patients with hip fractures differ on the structure level, not on the bone hard tissue level

2002 • 171 citations

Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice

1999 • 170 citations

Trabecular architecture in women and men of similar bone mass with and without vertebral fracture: II. three-dimensional histology

2000 • 168 citations

Bone Response to In Vivo Mechanical Loading in Two Breeds of Mice

1998 • 167 citations

Discriminatory Ability of Quantitative Ultrasound Parameters and Bone Mineral Density in a Population-Based Sample of Postmenopausal Women With Vertebral Fractures: Results of the Basel Osteoporosis Study

2002 • 144 citations

A Whole-Genome Linkage Scan Suggests Several Genomic Regions Potentially Containing Quantitative Trait Loci for Osteoporosis

2002 • 140 citations

Osteoporosis Changes the Amount of Vertebral Trabecular Bone at Risk of Fracture but Not the Vertebral Load Distribution

2001 • 137 citations

Genetic influence on bone turnover in postmenopausal twins.

1996 • 136 citations

Comparison of Genome Screens for Two Independent Cohorts Provides Replication of Suggestive Linkage of Bone Mineral Density to 3p21 and 1p36

2003 • 136 citations

Genetic Epidemiological Approaches to the Search for Osteoporosis Genes

2000 • 135 citations

Genetic and Environmental Correlations Between Bone Formation and Bone Mineral Density: A Twin Study

1998 • 126 citations

Genome Screen for Quantitative Trait Loci Contributing to Normal Variation in Bone Mineral Density: The Framingham Study

2002 • 126 citations

Genetic Variations in Bone Density, Histomorphometry, and Strength in Mice

2000 • 119 citations

Family History and Risk of Osteoporotic Fracture

1998 • 118 citations

Biomechanical consequences of an isolated overload on the human vertebral body

2000 • 118 citations

Genome Screen for Quantitative Trait Loci Underlying Normal Variation in Femoral Structure

2001 • 118 citations

Variance component linkage analysis indicates a QTL for femoral neck bone mineral density on chromosome 1p36

2001 • 117 citations

Histomorphometric studies show that bone formation and bone mineral apposition rates are greater in C3H/HeJ (high-density) than C57BL/6J (low-density) mice during growth

1999 • 116 citations

Alkaline phosphatase levels and osteoprogenitor cell numbers suggest bone formation may contribute to peak bone density differences between two inbred strains of mice

1998 • 111 citations

Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain

1999 • 111 citations

Trabecular architecture in women and men of similar bone mass with and without vertebral fracture: I. two-dimensional histology

2000 • 109 citations

Hierarchical relationship between bone traits and mechanical properties in inbred mice

2003 • 106 citations

Chromosomal Mapping of Osteopenia-Associated Quantitative Trait Loci Using Closely Related Mouse Strains

2000 • 103 citations

Postnatal and Pubertal Skeletal Changes Contribute Predominantly to the Differences in Peak Bone Density Between C3H/HeJ and C57BL/6J Mice

2001 • 103 citations

Biomechanics of Age-Related Fractures

2001 • 100 citations

Mapping Quantitative Trait Loci That Influence Femoral Cross‐sectional Area in Mice

2002 • 95 citations

Genetic influences on type I collagen synthesis and degradation: further evidence for genetic regulation of bone turnover.

1994 • 94 citations

Cortical tibial bone volume in two strains of mice: effects of sciatic neurectomy and genetic regulation of bone response to mechanical loading

1999 • 91 citations

Confirmation and Fine Mapping of Chromosomal Regions Influencing Peak Bone Mass in Mice

2001 • 82 citations

Family History of Appendicular Fracture and Risk of Osteoporosis: A Population-Based Study

1999 • 80 citations

Generation of a New Congenic Mouse Strain to Test the Relationships Among Serum Insulin-like Growth Factor I, Bone Mineral Density, and Skeletal Morphology In Vivo

2002 • 78 citations

Genetic loci determining bone density in mice with diet-induced atherosclerosis

2001 • 77 citations

Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice

2000 • 75 citations

Genetic Effects for Femoral Biomechanics, Structure, and Density in C57BL/6J and C3H/HeJ Inbred Mouse Strains

2003 • 72 citations

Genetic Dissection of Femur Breaking Strength in a Large Population (MRL/MpJ×SJL/J) of F2 Mice: Single QTL Effects, Epistasis, and Pleiotropy

2002 • 69 citations

Predicting human vertebral bone strength by vertebral static histomorphometry

2002 • 66 citations

Congenic Strains of Mice for Verification and Genetic Decomposition of Quantitative Trait Loci for Femoral Bone Mineral Density

2003 • 61 citations

Quantitative trait loci affecting growth in high growth (hg) mice

2001 • 53 citations

The effect of modelling and remodelling on human vertebral body architecture

1998 • 52 citations

Quantitative Trait Loci (QTLs) mapping for growth traits in the mouse: A review

2001 • 50 citations

Strain differences in bone density and calcium metabolism between c3h/hej and c57bl/6j mice

1999 • 41 citations

Chromosome 13 Locus, Pbd2, Regulates Bone Density in Mice

2001 • 36 citations

Genetics and Genomics of Osteoporosis

2001 • 31 citations

Quantitative genetic study of radiographic hand bone size and geometry

2003 • 26 citations

Correction: A comprehensive genetic map of the mouse genome (Nature (1996) 380 (149-152))

1996 • 25 citations

Characterization of a QTL affecting skeletal size in mice

2003 • 24 citations

Irresistible force meets immovable object: SNP mapping of complex diseases

2002 • 16 citations

Genomics and osteoporosis: What are the implications?

2004 • 1 citations