Intratumor chromosomal heterogeneity in advanced carcinomas of the uterine cervix

Genetic instabilities in human cancers

1998 • 4,165 citations

The multistep nature of cancer

1993 • 1,872 citations

Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors

1994 • 1,047 citations

Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix.

1996 • 470 citations

Guidelines for implementation of clinical DNA cytometry

1993 • 414 citations

Cancer of the Uterine Cervix

1996 • 379 citations

Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas.

2003 • 374 citations

Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: A phenotype/genotype correlation

1999 • 282 citations

Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q

1997 • 270 citations

Oncogene alterations in carcinomas of the uterine cervix: overexpression of the epidermal growth factor receptor is associated with poor prognosis.

1999 • 245 citations

The molecular genetics of cervical carcinoma

1999 • 202 citations

Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma

2003 • 180 citations

Prognostic factors in patients with cervix cancer treated by radiation therapy: results of a multiple regression analysis

1995 • 160 citations

Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes

1999 • 158 citations

Comparative genomic hybridization reveals a recurrent pattern of chromosomal aberrations in severe dysplasia/carcinoma in situ of the cervix and in advanced-stage cervical carcinoma

1999 • 135 citations

20q gain associates with immortalization: 20q13.2 amplification correlates with genome instability in human papillomavirus 16 E7 transformed human uroepithelial cells

1997 • 133 citations

Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence for chromosomal or microsatellite instability

1999 • 116 citations

Specific chromosomal imbalances in human papillomavirus-transfected cells during progression toward immortality

1997 • 90 citations

Disease control of uterine cervical cancer: relationships to tumor oxygen tension, vascular density, cell density, and frequency of mitosis and apoptosis measured before treatment and during radiotherapy.

2000 • 90 citations

Progressive genetic aberrations detected by comparative genomic hybridization in squamous cell cervical cancer

2000 • 82 citations

Comparison of fluorescein isothiocyanate- and Texas red-conjugated nucleotides for direct labeling in comparative genomic hybridization

1998 • 80 citations

Intratumoral cytogenetic heterogeneity detected by comparative genomic hybridization and laser scanning cytometry in human gliomas.

1998 • 80 citations

Genetic alterations during the progression of squamous cell carcinomas of the uterine cervix

1999 • 75 citations

Microsatellite instability in cervical and endometrial carcinomas

1997 • 70 citations

Genetic analysis identifies putative tumor suppressor sites at 2q35–q36.1 and 2q36.3–q37.1 involved in cervical cancer progression

2003 • 69 citations

Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix

2001 • 65 citations

Tumor heterogeneity and progression: conceptual foundations for modeling.

1996 • 61 citations

Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semi-automated fluorescence-based detection: subregional mapping of chromosome 4 in cervical carcinoma.

1996 • 54 citations

Chromosome abnormalities in ovarian adenocarcinoma: III. Using breakpoint data to infer and test mathematical models for oncogenesis

2000 • 50 citations

Analysis of Intratumoral Heterogeneity of Chromosome 3p Deletions and Genetic Evidence of Polyclonal Origin of Cervical Squamous Carcinoma

2001 • 48 citations

Intratumor variability in prognostic indicators may be the cause of conflicting estimates of patient survival and response to therapy.

1994 • 42 citations

P53 EXPRESSION IS ASSOCIATED WITH A HIGH-DEGREE OF TUMOR DNA ANEUPLOIDY AND INCIDENCE OF P53 GENE MUTATION, AND IS LOCALIZED TO THE ANEUPLOID COMPONENT IN COLORECTAL CARCINOMAS

1993 • 27 citations

The relevance of oncogenes as prognostic markers in cervical cancer

2002 • 22 citations

Clonality Analysis of Synchronous Lesions of Cervical Carcinoma Based on X Chromosome Inactivation Polymorphism, Human Papillomavirus Type 16 Genome Mutations, and Loss of Heterozygosity

2002 • 21 citations

Genetic deletion and human papillomavirus infection in cervical cancer: Loss of heterozygosity sites at 3p and 5p are important genetic events

1999 • 17 citations

Allelic imbalance in hMLH1 or BRCA2 loci associated with response of cervical and endometrial cancer to radiotherapy

2002 • 9 citations

Genetic alterations on chromosome 17p associated with response to radiotherapy in bulky cervical cancer

1999 • 7 citations

DNA Content in Cervical Carcinoma

1994 • 4 citations