Through the Looking Glass: Differential Noradenergic Modulation of Prefrontal Cortical Function

Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex

1989 • 2,677 citations

Decision and stress

1971 • 1,686 citations

β-Adrenergic activation and memory for emotional events

1994 • 1,277 citations

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

1997 • 1,228 citations

Supranormal Stimulation of D₁Dopamine Receptors in the Rodent Prefrontal Cortex Impairs Spatial Working Memory Performance

1997 • 805 citations

Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey

1970 • 581 citations

Dissociating executive functions of the prefrontal cortex

1996 • 574 citations

α ₂ -Adrenergic Mechanisms in Prefrontal Cortex Associated with Cognitive Decline in Aged Nonhuman Primates

1985 • 544 citations

Different Training Procedures Recruit Either One or Two Critical Periods for Contextual Memory Consolidation, Each of Which Requires Protein Synthesis and PKA

1998 • 523 citations

Modified hippocampal long-term potentiation in PKCγ-mutant mice

1993 • 507 citations

Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats

1997 • 500 citations

Catecholamine regulation of the prefrontal cortex

1997 • 478 citations

Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal ltp in the range of the θ frequency

1995 • 464 citations

Frontal lesions and sustained attention

1987 • 457 citations

Effects of putative neurotransmitters on neuronal activity in monkey auditory cortex

1975 • 451 citations

Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory

1998 • 431 citations

Memory Consolidation for Contextual and Auditory Fear Conditioning Is Dependent on Protein Synthesis, PKA, and MAP Kinase

1999 • 403 citations

The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes

1988 • 386 citations

Role of the Amygdala in the Coordination of Behavioral, Neuroendocrine, and Prefrontal Cortical Monoamine Responses to Psychological Stress in the Rat

1996 • 383 citations

Postsynaptic Induction and PKA-Dependent Expression of LTP in the Lateral Amygdala

1998 • 332 citations

Modulation of Long-Term Synaptic Depression in Visual Cortex by Acetylcholine and Norepinephrine

1999 • 319 citations

Clonidine Benefits Children with Attention Deficit Disorder and Hyperactivity: Report of a Double-Blind Placebo-Crossover Therapeutic Trial

1985 • 315 citations

Noradrenergic enhancement of long-term potentiation at mossy fiber synapses in the hippocampus

1988 • 314 citations

The action of norepinephrine in the rat hippocampus. IV. The effects of locus coeruleus stimulation on evoked hippocampal unit activity

1976 • 304 citations

An Open Trial of Guanfacine in the Treatment of Attention-Deficit Hyperactivity Disorder

1995 • 303 citations

Modulation of memory storage

1996 • 299 citations

Amygdala Modulation of Multiple Memory Systems: Hippocampus and Caudate-Putamen

1998 • 285 citations

Effect of Loud Noise on Attentional Selectivity

1970 • 285 citations

Prefrontal cortex gating of auditory transmission in humans

1989 • 253 citations

Guanfacine Treatment of Comorbid Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome: Preliminary Clinical Experience

1995 • 250 citations

Basolateral Amygdala Noradrenergic Influences on Memory Storage Are Mediated by an Interaction between β- and α₁-Adrenoceptors

1999 • 243 citations

Noradrenergic modulation of somatosensory cortical neuronal responses to lontophoretically applied putative neurotransmitters

1980 • 212 citations

Actions of norepinephrine in the cerebral cortex and thalamus: implications for function of the central noradrenergic system

1991 • 204 citations

Alpha-receptor-mediated facilitation of somatosensory cortical neuronal responses to excitatory synaptic inputs and iontophoretically applied acetylcholine

1981 • 184 citations

Guanfacine, But Not Clonidine, Improves Planning and Working Memory Performance in Humans

1999 • 184 citations

Delayed-response deficit induced by local injection of the α2-adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys

1994 • 181 citations

Alpha-2 Adrenergic Modulation of Prefrontal Cortical Neuronal Activity Related to Spatial Working Memory in Monkeys

1999 • 158 citations

Gating of somatosensory input by human prefrontal cortex

1990 • 155 citations

Enhancement of Behavioral and Electroencephalographic Indices of Waking following Stimulation of Noradrenergic β-Receptors within the Medial Septal Region of the Basal Forebrain

1996 • 152 citations

Alteration of brain noradrenergic activity in rhesus monkeys affects the alerting component of covert orienting

1997 • 149 citations

The action of norepinephrine in the dentate gyrus: Beta-mediated facilitation of evoked potentials in vitro

1985 • 139 citations

Phasic activation of the locus coeruleus enhances responses of primary sensory cortical neurons to peripheral receptive field stimulation

1998 • 138 citations

Behavioral consequences of adaptation to controllable and uncontrollable noise

1971 • 125 citations

Does Stress Cause Psychiatric Illness?

1996 • 124 citations

Reserpine impairs spatial working memory performance in monkeys: reversal by the α2-adrenergic agonist clonidine

1993 • 121 citations

Noradrenergic Control of Thalamic Oscillation: the Role of α‐2 Receptors

1991 • 120 citations

Guanfacine for Treatment of Attention-Deficit Hyperactivity Disorder in Boys

1995 • 118 citations

The α -2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys

1998 • 117 citations

The Neural Correlates of the Noradrenergic Modulation of Human Attention, Arousal and Learning

1997 • 112 citations

Effects of Noradrenaline on Frequency Tuning of Rat Auditory Cortex Neurons

1997 • 109 citations

Cognitive enhancement in Korsakoff's psychosis by clonidine: A comparison with l-Dopa and Ephedrine

1986 • 104 citations

Noradrenergic potentiation of excitatory transmitter action in cerebrocortical slices: evidence for mediation by an α1 receptor-linked second messenger pathway

1991 • 103 citations

Effect of noise on the Stroop test.

1974 • 102 citations

LTP in the lateral perforant path is β-adrenergic receptor-dependent

1997 • 97 citations

Characterization of [3H]RX821002 binding to alpha-2 adrenergic receptor subtypes.

1994 • 87 citations

Consolidation of Memory After its Reactivation: Involvement of ß Noradrenergic Receptors in the Late Phase

1998 • 87 citations

Clonidine improves memory function in schizophrenia independently from change in psychosis☆Preliminary findings

1988 • 87 citations

The α-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys.

1997 • 86 citations

Dissociating executive functions of the prefrontal cortex

1998 • 85 citations

Restoration of cholinomimetic activity by clonidine in cholinergic plus noradrenergic lesioned rats

1990 • 83 citations

Guanfacine and Clonidine, Alpha2-Agonists, Improve Paired Associates Learning, but not Delayed Matching to Sample, in Humans

1999 • 81 citations

Late and prolonged post-training memory modulation in entorhinal and parietal cortex by drugs acting on the cAMP/protein kinase A signalling pathway

1997 • 77 citations

Medetomidine, atipamezole, and guanfacine in delayed response performance of aged monkeys

1996 • 74 citations

The effects of prefrontal intracortical microinjections of an alpha-2 agonist, alpha-2 antagonist and lidocaine on the delayed alternation performance of aged rats

1996 • 72 citations

Modulation of forebrain electroencephalographic activity in halothane-anesthetized rat via actions of noradrenergic beta-receptors within the medial septal region.

1996 • 70 citations

Behavioral and receptor binding analysis of the α2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-YL amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an α2-adrenoceptor subtype

1991 • 67 citations

Clonidine enhances delayed matching-to-sample performance by young and aged monkeys

1991 • 65 citations

The role of norepinephrine in adult rat somatosensory (SmI) cortical metabolism and plasticity

1988 • 62 citations

Effects of medetomidine, an α-2 adrenoceptor agonist, and atipamezole, an α-2 antagonist, on spatial memory performance in adult and aged rats

1992 • 62 citations

Identification of [3H]prazosin binding sites in crude membranes and isolated cells of brown adipose tissue as α1-adrenergic receptors

1983 • 61 citations

Acute phorbol ester treatment improves spatial learning performance in rats

1991 • 56 citations

Attenuation of Delay-Period Activity of Monkey Prefrontal Neurons by an α₂-Adrenergic Antagonist During an Oculomotor Delayed-Response Task

1998 • 56 citations

Age-related prefrontal alterations during auditory memory

1997 • 54 citations

Role of α_2C‐adrenoceptor subtype in spatial working memory as revealed by mice with targeted disruption of the α_2C‐adrenoceptor gene

1999 • 52 citations

Stimulation of alpha-1 adrenergic receptors facilitates spatial learning in rats

1998 • 42 citations

The effects of guanfacine, α-2 agonist, on the performance of young and aged rats in spatial navigation task

1991 • 34 citations

Intracerebroventricular norepinephrine potentiation of the perforant path-evoked potential in dentate gyrus of anesthetized and awake rats: A role for both α- and β-adrenoceptor activation

1998 • 33 citations

THA Improves Word Priming and Clonidine Enhances Fluency and Working Memory in Alzheimer's Disease

1999 • 29 citations

Effects of F lunarizine and Nitrendipine on Electroconvulsive Shock- and Clonidine-Induced Amnesia

1997 • 24 citations

Minor role for ?1-adrenoceptors in the facilitation of induction and early maintenance of long-term potentiation in the CA1 field of the hippocampus

1998 • 22 citations

EFFECTS OF MEDETOMIDINE, AN ALPHA-2 ADRENOCEPTOR AGONIST, AND ATIPAMEZOLE, AN ALPHA-2 ANTAGONIST, ON SPATIAL MEMORY PERFORMANCE IN ADULT AND AGED RATS

1992 • 14 citations