The Folding of Chromatin

Chromatin Structure: A Repeating Unit of Histones and DNA

1974 • 2,514 citations

Physical Principles in the Construction of Regular Viruses

1962 • 2,446 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromatin.

1979 • 1,532 citations

Spheroid Chromatin Units (ν Bodies)

1974 • 1,366 citations

Solenoidal model for superstructure in chromatin.

1976 • 1,223 citations

Chromatin sub-structure. The digestion of chromatin DNA at regularly spaced sites by a nuclear deoxyribonuclease

1973 • 1,176 citations

The structure of histone-depleted metaphase chromosomes

1977 • 1,083 citations

Nucleosome Structure

1980 • 923 citations

Visualization of Nucleolar Genes

1969 • 865 citations

Electron microscopic and biochemical evidence that chromatin structure is a repeating unit

1975 • 860 citations

Subunit structure of chromatin

1974 • 764 citations

Nucleosomes are assembled by an acidic protein which binds histones and transfers them to DNA

1978 • 763 citations

Structure of nucleosome core particles of chromatin

1977 • 746 citations

An octamer of histones in chromatin and free in solution.

1975 • 725 citations

Action of micrococcal nuclease on chromatin and the location of histone H1

1977 • 686 citations

Structure of the chromatosome, a chromatin particle containing 160 base pairs of DNA and all the histones

1978 • 583 citations

Isolation, characterization, and structure of the folded interphase genome of Drosophila melanogaster

1976 • 556 citations

Metaphase chromosome structure: Evidence for a radial loop model

1979 • 552 citations

Histones

1979 • 538 citations

Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei.

1976 • 523 citations

Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNAase I

1980 • 486 citations

Structure of Chromatin

1971 • 462 citations

DNA flexibility studied by covalent closure of short fragments into circles.

1981 • 456 citations

The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence

1979 • 445 citations

A 200 base pair region at the 5$prime; end of the chicken adult $beta;-globin gene is accessible to nuclease digestion

1981 • 443 citations

Higher order metaphase chromosome structure: Evidence for metalloprotein interactions

1982 • 398 citations

Assembly of SV40 chromatin in a cell-free system from Xenopus eggs

1977 • 358 citations

The histone core complex: an octamer assembled by two sets of protein-protein interactions

1978 • 357 citations

Interaction of HMG 14 and 17 with actively transcribed genes

1980 • 355 citations

Isolation of a subclass of nuclear proteins responsible for conferring a DNase I-sensitive structure on globin chromatin.

1979 • 337 citations

Comparison of the digestion of nuclei and chromatin by staphylococcal nuclease

1975 • 317 citations

A low resolution structure for the histone core of the nucleosome

1980 • 309 citations

Investigation of the flexibility of DNA using transient electric birefringence

1981 • 307 citations

Involvement of histone H1 in the organization of the chromosome fiber.

1977 • 278 citations

A stretch of “late” SV40 viral DNA about 400 bp long which includes the origin of replication is specifically exposed in SV40 minichromosomes

1979 • 278 citations

Analysis of subunit organization in chicken erythrocyte chromatin.

1976 • 272 citations

Role of nonhistone proteins in metaphase chromosome structure

1977 • 269 citations

Cleavage of DNA in nuclei and chromatin with staphylococcal nuclease

1975 • 253 citations

Assembly of nucleosomes: the reaction involving X. laevis nucleoplasmin

1980 • 248 citations

Orientation of the nucleosome within the higher order structure of chromatin

1980 • 242 citations

Changes in chromatin folding in solution

1980 • 235 citations

Non-histone proteins and long-range organization of HeLa interphase DNA

1982 • 231 citations

Histories H1 and H5: one or two molecules per nucleosome?

1981 • 211 citations

Variation in chromatin structure in two cell types from the same tissue: a short DNA repeat length in cerebral cortex neurons

1977 • 209 citations

Comparative organization of active transcription units in Oncopeltus fasciatus

1976 • 205 citations

Analysis of DNA of isolated chromatin subunits.

1975 • 202 citations

Acidic polypeptides can assemble both histones and chromatin in vitro at physiological ionic strength.

1979 • 190 citations

Super-helical Model for Nucleohistone

1967 • 189 citations

Domains in Chromatin Structure

1978 • 186 citations

CHROMOSOME STRUCTURE

1970 • 183 citations

Evidence for two levels of DNA folding in histone-depleted HeLa interphase nuclei

1982 • 180 citations

Partial Purification of the Template-Active Fraction of Chromatin: A Preliminary Report

1974 • 175 citations

Comparative subunit structure of HeLa, yeast, and chicken erythrocyte chromatin.

1977 • 171 citations

Higher‐Order Structures of Chromatin in Solution

1979 • 166 citations

Nucleosome Structure III: The Structure and Transcriptional Activity of the Chromatin Containing the Ovalbumin and Globin Genes in Chick Oviduct Nuclei

1978 • 161 citations

Exchange of histone H1 between segments of chromatin

1981 • 155 citations

Nucleosome assembly

1980 • 154 citations

Supercoiling energy and nucleosome formation: the role of the arginine-rich histone kernel

1977 • 151 citations

A comparison of the structure of chicken erythrocytef and chicken liver chromatin

1976 • 148 citations

X-ray diffraction studies of the molecular structure of nucleohistone and chromosomes

1959 • 147 citations

Unravelled nucleosomes, nucleosome beads and higher order structures of chromatin: Influence of non-histone components and histone H1

1981 • 143 citations

Mammalian chromatin substructure studies with the calcium–magnesium endonuclease and two-dimensional polyacrylamide-gel electrophoresis

1974 • 142 citations

A super-coil model for nucleohistone

1972 • 141 citations

The chromosome fiber: Evidence for an ordered superstructure of nucleosomes

1977 • 141 citations

Small angle neutron scattering studies of chromatin subunits in solution

1977 • 138 citations

The nucleosome repeat length increases during erythropoiesis in the chick

1978 • 138 citations

Primary organization of the nucleosome core particles sequential arrangement of histones along DNA

1980 • 133 citations

Higher-order structure of human mitotic chromosomes.

1977 • 132 citations

A major soluble acidic protein located in nuclei of diverse vertebrate species

1980 • 131 citations

Primary organization of nucleosome core particle of chromatin: sequence of histone arrangement along DNA.

1978 • 124 citations

A low resolution model for the chromatin core particle by neutron scattering

1977 • 121 citations

Stability of the Higher-Order Structure of Chicken-Erythrocyte Chromatin in Solution

1981 • 119 citations

GLUTARALDEHYDE FIXATION OF ISOLATED EUCARYOTIC NUCLEI

1973 • 119 citations

Fine structure of the origin-proximal DNAase I-hypersensitive region in wild-type and EC mutant polyoma

1981 • 114 citations

Characterization of the octamer of histones free in solution

1977 • 109 citations

X-ray diffraction study of a new crystal form of the nucleosome core showing higher resolution

1981 • 108 citations

In vitro core particle and nucleosome assembly at physiological ionic strength.

1979 • 97 citations

Cleavable cross‐links in the analysis of histone—histone associations

1975 • 96 citations

Organization of chromosomes in hela cells: Isolation of histone-depleted nuclei and nuclear scaffolds

1980 • 94 citations

Closely Spaced Nucleosome Cores in Reconstituted Histone . DNA Complexes and Histone-H1-Depleted Chromatin

1978 • 92 citations

Structure of the active nucleolar chromatin of Xenopus laevis oocytes

1982 • 89 citations

Conformational changes of the chromatin subunit.

1978 • 89 citations

Ribonucleic acid and other polyanions facilitate chromatin assembly in vitro

1981 • 88 citations

Subunit structure of rDNA-containing chromatin

1976 • 86 citations

Nicking-closing enzyme assembles nucleosome-like structures in vitro.

1979 • 85 citations

The higher order structure of chicken erythrocyte chromosomes in vivo

1980 • 85 citations

Stability and reversibility of higher ordered structure of interphase chromatin: continuity of deoxyribonucleic acid is not required for maintenance of folded structure

1980 • 80 citations

Limited action of micrococcal nuclease on trout testis nuclei generates two mononucleosome subsets enriched in transcribed DNA sequences.

1979 • 78 citations

The higher order repeat structure of chromatin is built up of globular particles containing eight nucleosomes

1978 • 78 citations

Cross‐linking of Histone H1 in Chromatin

1980 • 78 citations

X-ray studies on “Native” chromatin

1977 • 73 citations

The number of charge-charge interactions stabilizing the ends of nucleosome DNA

1980 • 73 citations

Light scattering measurements supporting helical structures for chromatin in solution

1978 • 71 citations

Solution structural studies of chromatin fibers

1981 • 71 citations

Neutron diffraction studies on crystals of nucleosome cores using contrast variation

1981 • 71 citations

Rapid reformation of the thick chromosome fiber upon completion of RNA synthesis at the Balbiani ring genes in Chironomus tentans

1982 • 68 citations

Role of histone H1 in the conformation of oligonucleosomes as a function of ionic strength

1979 • 64 citations

Protein-depleted chromosomes

1981 • 62 citations

Disruption of the typical chromatin structure in a 2500 base-pair region at the 5′ end of the actively transcribed ovalbumin gene.

1982 • 62 citations

The mass per unit length of chromatin by low‐angle X‐ray scattering

1976 • 61 citations

Protein-depleted chromosomes

1981 • 61 citations

Size-dependence of a stable higher-order structure of chromatin

1980 • 59 citations

Crosslinked histone octamer as a model of the nucleosome core.

1977 • 57 citations

Studies an chromatin. II. Isolation and characterization of chromatin subunits

1975 • 55 citations

Ultrastructural organization of yeast chromatin.

1982 • 55 citations

The sub-structure of nucleosomes

1977 • 55 citations

Variable center to center distance of nucleosomes in chromatin

1982 • 54 citations

Specific histone-histone contacts are ruptured when nucleosomes unfold at low ionic strength

1979 • 51 citations

Organization of chromosomes in mitotic HeLa cells

1980 • 50 citations

Supranucleosomal structure of chromatin: digestion by calcium/magnesium endonuclease proceeds via a discrete size class of particles with elevated stability

1981 • 49 citations

Electron microscope specimen preparation of rat liver chromatin by a modified Miller spreading technique.

1981 • 48 citations

Nucleosome periodicity in HeLa cell chromatin as probed by micrococcal nuclease.

1979 • 47 citations

Chemical and physical properties of fractionated chromatin.

1975 • 47 citations

Nucleosomes arrangement in chromatin

1978 • 44 citations

Chromatin superstructure: The next level of structure above the nucleosome has an alternating character. A two-nucleosome based series is generated by probes armed with DNAase-I acting on isolated nuclei

1981 • 42 citations

Upon the observation of superbeads in chromatin

1980 • 39 citations

Involvement of higher order chromatin structures in metaphase chromosome organization

1982 • 39 citations

A repeating unit of higher order chromatin structure in chick red blood cell nuclei

1980 • 37 citations

Orientation of nucleosomes in the 30 nm chromatin fiber

1982 • 35 citations

Nucleodisome — a new repeat unit of chromatin revealed in nuclei of pigeon erythrocytes by DNase I digestion

1981 • 34 citations

Quasielastic light scattering by biopolymers. Conformation of chromatin multimers

1976 • 33 citations

Repeating oligonucleosomal units. A new element of chromatin structure

1980 • 32 citations

Histone H1 Involvement in the Structure of the Chromosome Fiber

1978 • 30 citations

Non-histone proteins and the structure of metaphase chromosomes

1978 • 30 citations

Heterogeneity of the chromosome fiber

1979 • 30 citations

Conformation of Chromatin Oligomers

1981 • 30 citations

Nucleomeric Organization of Chromatin

1982 • 26 citations

Chromatin repeat length correlates with phenotypic expression in hepatoma cells, their dedifferentiated variants, and somatic hybrids.

1980 • 25 citations

Characterization of rat liver oligonucleosomes enriched in transcriptionally active genes: evidence for altered base composition and a shortened nucleosome repeat

1981 • 25 citations

A serial sectioning study of the structure of human mitotic chromosomes.

1981 • 25 citations

Structural Investigations on Isolated Chromatin of Higher‐Order Organisation

1981 • 24 citations

Aggregation of small oligonucleosomal chains into 300-A globular particles.

1980 • 24 citations

The Nucleosome Core Protein

1978 • 24 citations

The structural organization of dinudeosomes and oligonucleosomes. Electric dichroism and birefringence study

1981 • 24 citations

A quantitative analysis of histone H1 in rabbit thymus nuclei

1977 • 23 citations

Structural conformations of nucleosomes at low ionic strength from flow birefringence and intrinsic viscosity

1981 • 23 citations

Scattering Studies of Chromatin Subunits

1978 • 23 citations

Neutron diffraction from crystals of nucleosome core particles

1980 • 22 citations

Morphology of transcriptional units at different states of activity

1978 • 22 citations

Effect of DNA length on the nucleosome low salt transition

1980 • 19 citations

Iodination of nucleosomes at low ionic strength: conformational changes in H4 and stabilization by H1

1981 • 18 citations

Chromatin repeat length in somatic hybrids.

1980 • 16 citations

Unfolding of 175-base-pair nucleosomes

1982 • 14 citations

Presence of histone H1 and the electric birefringence behaviour of nucleosome frations from sucrose gradient and column chromatography

1981 • 12 citations

Core particle stability critically depends upon a small number of terminal nucleotides

1981 • 11 citations

I. Structure of chromatin. Introductory remarks

1978 • 10 citations

Higher order chromatin structure determines double-nucleosome periodicity of DNA fragmentation

1982 • 9 citations

Conformation of Polynucleosomes in Low Ionic Strength Solution

1979 • 8 citations

EVIDENCE FOR A STRUCTURAL ROLE OF COPPER IN HISTONE-DEPLETED CHROMOSOMES AND NUCLEI

1981 • 1 citations