Hemophilia treatment in historical perspective: a review of medical and social developments

The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex

1987 • 3,000 citations

Prevalence of Total Coronary Occlusion during the Early Hours of Transmural Myocardial Infarction

1980 • 2,722 citations

HAEMOSTATIC FUNCTION AND ISCHAEMIC HEART DISEASE: PRINCIPAL RESULTS OF THE NORTHWICK PARK HEART STUDY

1986 • 1,989 citations

Fibrinogen as a Risk Factor for Stroke and Myocardial Infarction

1984 • 1,686 citations

The Gift Relationship: From Human Blood to Social Policy.

1971 • 1,322 citations

Zidovudine in Asymptomatic Human Immunodeficiency Virus Infection

1990 • 1,288 citations

HEPATITIS C VIRUS ANTIBODIES AMONG RISK GROUPS IN SPAIN

1989 • 910 citations

The Gift Relationship: From Human Blood to Social Policy.

1972 • 644 citations

A Prospective Study of Human Immunodeficiency Virus Type 1 Infection and the Development of AIDS in Subjects with Hemophilia

1989 • 536 citations

The rate of spontaneous mutation of a human gene

1935 • 510 citations

Fibrinogen, cigarette smoking, and risk of cardiovascular disease: Insights from the Framingham Study

1987 • 472 citations

The Gift Relationship

2018 • 427 citations

Safety and efficacy of sulfamethoxazole and trimethoprim chemoprophylaxis for Pneumocystis carinii pneumonia in AIDS

1988 • 427 citations

The Effect of Activated Prothrombin-Complex Concentrate (FEIBA) on Joint and Muscle Bleeding in Patients with Hemophilia A and Antibodies to Factor VIII

1981 • 303 citations

High-potency Antihæmophilic Factor Concentrate prepared from Cryoglobulin Precipitate

1964 • 300 citations

THE MUTATION RATE OF THE GENE FOR HAEMOPHILIA, AND ITS SEGREGATION RATIOS IN MALES AND FEMALES

1946 • 226 citations

Haemostasis and Thrombosis

1988 • 221 citations

Non-A non-B hepatitis after transfusion of factor VIII in infrequently treated patients.

1983 • 219 citations

Mortality and causes of death in Dutch haemophiliacs, 1973–86

1989 • 209 citations

Treasury of Human Inheritance.

1912 • 206 citations

Pneumocystis carinii pneumonia among persons with hemophilia A.

1982 • 194 citations

The natural history of factor VIII:C inhibitors in patients with hemophilia A: a national cooperative study. II. Observations on the initial development of factor VIII:C inhibitors

1988 • 171 citations

Activated Prothrombin Concentrate for Patients with Factor VIII Inhibitors

1974 • 163 citations

Use of Recombinant Antihemophilic Factor in the Treatment of Two Patients with Classic Hemophilia

1989 • 162 citations

Absence of Hepatitis after Treatment with a Pasteurized Factor VIII Concentrate in Patients with Hemophilia and No Previous Transfusions

1987 • 160 citations

HAEMOPHILIA PROPHYLAXIS IN SWEDEN

1976 • 158 citations

The Use of Porcine Factor VIII Concentrate (Hyate:C) in the Treatment of Patients With Inhibitor Antibodies to Factor VIII

1989 • 151 citations

A study of liver biopsies and liver disease among hemophiliacs

1985 • 150 citations

Life expectancy of Swedish haemophiliacs, 1831–1980

1985 • 149 citations

Haemophilia protects against ischaemic heart disease: a study of risk factors

1990 • 149 citations

Pneumocystis carinii pneumonia among persons with hemophilia A.

1982 • 140 citations

Treatment of haemophilia and related disorders in Britain and Northern Ireland during 1976-80: report on behalf of the directors of haemophilia centres in the United Kingdom.

1983 • 139 citations

Sociaal en cultureel rapport 1992 (2)

1993 • 127 citations

Hemophilia in the Talmud and Rabbinic Writings

1969 • 125 citations

Asymptomatic Structural Liver Disease in Hemophilia

1978 • 123 citations

PROGRESSIVE LIVER DISEASE IN HAEMOPHILIA: AN UNDERSTATED PROBLEM?

1985 • 120 citations

Jaundice and Antibodies Directed against Factors VIII and IX in Patients Treated for Haemophilia or Christmas Disease in the United Kingdom

1974 • 111 citations

Factor VIII inhibitors

1985 • 109 citations

Haemophilia in Sweden

1962 • 108 citations

A CONCENTRATE OF HUMAN ANTIHÆMOPHILIC FACTOR

1957 • 108 citations

Disappearance of factor VIII:C antibodies in patients with haemophilia A upon frequent administration of factor VIII in intermediate or low dose

1986 • 107 citations

Antibodies reactive with human T cell leukemia viruses in the serum of hemophiliacs receiving factor VIII concentrate

1985 • 100 citations

RADIOLOGIC EVALUATION OF PROPHYLAXIS IN SEVERE HAEMOPHILIA

1981 • 99 citations

HTLV-III SEROPOSITIVITY IN EUROPEAN HAEMOPHILIACS EXPOSED TO FACTOR VIII CONCENTRATE IMPORTED FROM THE USA

1984 • 94 citations

Home Transfusion for Patients with Hemophilia A

1970 • 93 citations

The effect of activated prothrombin-complex concentrate (FEIBA) on joint and muscle bleedings in patients with haemophilia A with an inhibitor to Factor VIII

1982 • 90 citations

The history of haemophilia.

1976 • 90 citations

Possible transfusion-associated acquired immune deficiency syndrome (AIDS) - California.

1982 • 90 citations

Supervised Patient-Management of Hemophilia

1973 • 89 citations

The natural history of factor VIII inhibitors in patients with hemophilia A.

1984 • 85 citations

Modern haemophilia treatment: medical improvements and quality of life

1990 • 84 citations

Changes in the life expectancy of patients with severe haemophilia A in Finland in 1930‐79

1982 • 84 citations

Our Experience in Sweden with Prophylaxis on Haemophilia1

2015 • 82 citations

HÆMORRHAGIC DIATHESIS.

1840 • 82 citations

Cause of death in hemophilia a patients in the United States from 1968 to 1979

1988 • 81 citations

Prophylaxis of Joint Hemorrhages in Hemophilia

1971 • 80 citations

Efficacy of Self-Therapy in Hemophilia

1974 • 77 citations

Incidence of inhibitors in patients with severe and moderate hemophilia a treated with factor VIII concentrates

1987 • 77 citations

Expression of functional factor VIII in primary human skin fibroblasts after retrovirus-mediated gene transfer.

1990 • 74 citations

Absence of Anti-Human Immunodeficiency Virus Types 1 and 2 Seroconversion after the Treatment of Hemophilia A or von Willebrand's Disease with Pasteurized Factor VIII Concentrate

1989 • 74 citations

The Preparation and Assay of a Christmas‐Factor (Factor IX) Concentrate and its Use in the Treatment of Two Patients

1961 • 71 citations

Physical condition, longevity, and social performance of Dutch haemophiliacs, 1972-85.

1989 • 69 citations

Haemophilia Treatment in the United Kingdom from 1969 to 1974

1977 • 69 citations

ACQUIRED IMMUNODEFICIENCY SYNDROME AMONG PATIENTS ATTENDING HEMOPHILIA TREATMENT CENTERS AND MORTALITY EXPERIENCE OF HEMOPHILIACS IN THE UNITED STATES

1985 • 67 citations

Carrier testing and prenatal diagnosis for hemophilia: Experiences and attitudes of 549 potential and obligate carriers

1990 • 65 citations

Deaths in Swedish Hemophiliacs, 1957–1980

1983 • 61 citations

Socioeconomic Evaluation of a State-Funded Comprehensive Hemophilia-Care Program

1982 • 57 citations

Prophylaxis in Haemophilia: A Double‐blind Controlled Trial

1976 • 55 citations

Effect of frequent factor VIII replacement on the level of factor VIII antibodies in haemophiliacs

1982 • 53 citations

Renal Complications in Haemophilia and Christmas Disease

1971 • 48 citations

Factor VIII:C concentrate purified from plasma using monoclonal antibodies: human studies

1989 • 44 citations

Genetic predisposition to develop factor VIII antibody in classic hemophilia

1977 • 40 citations

Current Status of Swedish Hemophiliacs

1982 • 40 citations

Treatment of a high titer anti-factor-VIII antibody by continuous factor VIII administration: report of a case.

1983 • 40 citations

Suppression of Factor IX Antibody in Hemophilia B by Factor IX and Cyclophosphamide

1973 • 38 citations

A maximum likelihood estimate of the sex ratio of mutation rates in Haemophilia A

1983 • 38 citations

Haemophilia and the kidney: assessment after 11-year follow-up.

1982 • 37 citations

LIFE EXPECTANCY OF SWEDISH HAEMOPHILIACS

1985 • 37 citations

Sex ratio of the mutation frequencies in haemophilia A: estimation and meta-analysis

1990 • 34 citations

The high risk of chronic liver disease in multitransfused juvenile hemophiliac patients

1979 • 33 citations

Home Transfusions of Hemophiliacs

1972 • 33 citations

Twice weekly prophylactic therapy in haemophilia A.

1977 • 33 citations

["COAGULANT" FRACTIONS CONTAINING COAGULATION FACTORS ADSORBABLE BY TRICALCIC PHOSPHATE].

1964 • 32 citations

The Preparation for Therapeutic Use of a Concentrate of Factor IX Containing also Factors II, VII and X

1967 • 32 citations

Factor VIII inhibitor by-passing activity (FEIBA) in the management of patients with factor VIII inhibitors

1977 • 29 citations

Coronary artery disease in severe haemophilia.

1983 • 28 citations

Prophylactic therapy in classical hemophilia: a preliminary report.

1967 • 27 citations

Vitamin B6 concentrations in patients with chronic liver disease and hepatocellular carcinoma.

1986 • 26 citations

Incidence and Course of Inhibitors among Patients with Classic Hemophilia

1973 • 26 citations

Hemophilia hometransfusion program: Effect on school attendance

1972 • 26 citations

Treatment of haemophilia B with purified Factor IX (PPSB).

1967 • 25 citations

Current concepts in the management of hemophilia.

1975 • 25 citations

AIDS and Haemophilia

1988 • 24 citations

Haemophilic Diseases in Denmark

1962 • 24 citations

Immunoglobulin G Antibodies to Lymphadenopathy-Associated Virus in Differently Treated French and Belgian Hemophiliacs

1985 • 23 citations

MYOCARDIAL INFARCTION IN A HqMOPHILIAC

1959 • 23 citations

Employment of individuals with haemophilia in the Netherlands

1989 • 22 citations

HAEMOPHILIA IN SWEDEN

1962 • 21 citations

HIV infection in Norwegian haemophiliacs: The prevalence of antibodies against HIV in haemophiliacs treated with lyophilized cryoprecipitate from volunteer donors

1987 • 21 citations

The Treatment of Haemophilia A and B and von Willebrand's Disease.

1979 • 21 citations

Self-perception of employed and unemployed haemophiliacs

1980 • 19 citations

THE MANAGEMENT OF HEMOPHILIA

1942 • 19 citations

Factor VIII antibody in a patient with mild haemophilia

1985 • 19 citations

CARDIAC INFARCTION

1942 • 17 citations

Arteriosclerosis in severe hemophilia. A postmortem study.

1981 • 17 citations

Complications of Hemophilic Disorders Affecting the Renal Tract

1971 • 17 citations

A long‐term study of hemophilic arthropathy of the knee joint on a program of factor VIII replacement given at time of each hemarthrosis

1985 • 15 citations

A Factor VIII Inhibitor in a Mild Hemophiliac

1970 • 14 citations

Note on the Purification of Human Antihemophilic Globulin.

1958 • 14 citations

Haemophilia: a survey on social issues.

1977 • 14 citations

HIV‐serology and lymphocyte subsets in relation to therapy and clinical development in haemophiliacs

1988 • 13 citations

The urinary tract in haemophilia

1979 • 13 citations

15 Treatment and Prophylaxis of Arthropathy in Severe Hemophilia

1967 • 13 citations

Improving prospects for employment of the haemophiliac.

1980 • 13 citations

Hemophilia: A Study in Hope and Reality.

1970 • 12 citations

Treatment of haemophilia A with purified factor 8 obtained from human plasma by cryoprecipitation.

1967 • 12 citations

USE OF ANIMAL AHG CONCENTRATES (FACTOR VIII) IN THE TREATMENT OF LIFE‐THREATENING HEMORRHAGE IN PATIENTS WITH FACTOR VIII ANTIBODIES*

1975 • 9 citations

An innovative program of counseling family members and friends of seropositive haemophiliacs

1989 • 9 citations

Prevalence of antibodies to HTLV-III in AIDS risk groups in West Germany.

1985 • 9 citations

Hemophilia; with special reference to the Talmud.

1958 • 8 citations

Longevity of Haemophiliacs

1961 • 8 citations

Death in Hemophiliacs

1976 • 7 citations

Haemophilia, HIV Infection, and Blood Transfusion in Belgium

1988 • 7 citations

Nephromegaly in Hemophilia

1975 • 6 citations

THE HOME THERAPY PROGRAM AT THE NEW ENGLAND AREA HEMOPHILIA CENTER

1977 • 6 citations

Management of hemophilia.

1956 • 6 citations

Myocardial infarction in a hemophiliac.

1954 • 5 citations

The Mechanism of Haemostasis

1969 • 4 citations

News

1990 • 3 citations

Blood, HIV, and compensation.

1990 • 3 citations

[Separation of fibrinogen and of the antihemophilic factor A].

1957 • 3 citations

[Consensus hemophilia treatment].

1987 • 2 citations

[Causes of death in hemophilia patients in East Germany].

1985 • 2 citations

[Social effects of current hemophilia treatment].

1989 • 1 citations

Deleted Work

1955 • 0 citations