Separation and measurement of clofibroyl coenzyme a and clofibric acid in rat liver after clofibrate administration by reversed-phase high-performance liquid chromatography with photodiode array detection

A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug.

1976 • 1,136 citations

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

1980 • 854 citations

NATURE OF THE HEPATOMEGALIC EFFECT PRODUCED BY ETHYL-CHLOROPHENOXY-ISOBUTYRATE IN THE RAT

1965 • 599 citations

Review of the hepatic response to hypolipidaemic drugs in rodents and assessment of its toxicological significance to man

1981 • 233 citations

A New Method for the Preparation of Acyl-CoA Thioesters1

1981 • 169 citations

Enhancement of long-chain acyl-CoA hydrolase activity in peroxisomes and mitochondria of rat liver by peroxisomal proliferators

1984 • 128 citations

The hepatic effects of hypolipidemic drugs (clofibrate, nafenopin, tibric acid, and Wy-14,643) on hepatic peroxisomes and peroxisome-associated enzymes.

1978 • 126 citations

Changes in lipid metabolizing enzymes of hepatic subcellular fractions from rats treated with tiadenol and clofibrate

1981 • 75 citations

Correlation between the cellular level of long-chain acyl-coa, peroxisomal β-oxidation, and palmitoyl-CoA hydrolase activity in rat liver. Are the two enzyme systems regulated by a substrate-induced mechanism?

1985 • 75 citations

Xenobiotic acyl-coenzymes A: critical intermediates in the biochemical pharmacology and toxicology of carboxylic acids

1984 • 53 citations

The rapid induction of liver glycerophosphate acyltransferase in mice by clofibrate, a hypolipidemic agent.

1983 • 39 citations

Enzymatic changes in rat liver associated with low and high doses of a peroxisome proliferator

1984 • 36 citations

Acyl-CoA esters of xenobiotic carboxylic acids as biochemically active intermediates

1985 • 27 citations

Effect of 4-(4′-chlorobenzyloxy)benzyl nicotinate (KCD-232) on triglyceride and fatty acid metabolism in rats

1984 • 27 citations

Stimulation of fatty acid utilization by sodium clofibrate in rat and monkey hepatocytes

1983 • 20 citations

Novel xenobiotic-lipid conjugates

1985 • 19 citations

High-pressure liquid chromatographic analysis of drugs in biological fluids

1977 • 15 citations

Peroxisome proliferators show tumor‐promoting but no direct transforming activity in vitro

1986 • 14 citations

Co-oxidation of xenobiotics

1985 • 11 citations

A high pressure liquid chromatographic determination of p-chlorophenoxyisobutyric acid and its comparison to a GLC and an ultra violet spectrophotometric method

1978 • 6 citations

Rapid determination of clofibric acid in human plasma by high-performance liquid chromatography

1986 • 6 citations