Regulation of regional cerebral blood flow by cholinergic fibers originating in the basal forebrain

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects.

1986 • 2,017 citations

On the Regulation of the Blood‐supply of the Brain

1890 • 1,743 citations

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

1988 • 1,379 citations

Basic mechanisms of cerebral rhythmic activities

1990 • 1,135 citations

THE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN BY THE USE OF NITROUS OXIDE IN LOW CONCENTRATIONS

1945 • 1,049 citations

In vivo evaluation of microcirculation by coherent light scattering

1975 • 860 citations

<scp>l</scp>‐N^G‐nitro arginine (<scp>l</scp>‐NOARG), a novel, <scp>l</scp>‐arginine‐reversible inhibitor of endothelium‐dependent vasodilatation in vitro

1990 • 769 citations

Cortical projections arising from the basal forebrain: A study of cholinergic and noncholinergic components employing combined retrograde tracing and immunohistochemical localization of choline acetyltransferase

1984 • 739 citations

Activity of pallidal neurons during movement.

1971 • 734 citations

The nucleus basalis magnocellularis: The origin of a cholinergic projection to the neocortex of the rat

1980 • 617 citations

EFFECTS OF THYROTROPIN-RELEASING HORMONE IN DEPRESSION*1

1972 • 558 citations

Dementia of the Alzheimer Type

1980 • 518 citations

Central noradrenergic regulation of cerebral blood flow and vascular permeability.

1975 • 487 citations

Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system.

1981 • 486 citations

Continuous Measurement of Cerebral Cortical Blood Flow by Laser—Doppler Flowmetry in a Rat Stroke Model

1989 • 480 citations

Evidence for a cholinergic projection to neocortex from neurons in basal forebrain.

1979 • 459 citations

Cholinergic projections from magnocellular nuclei of the basal forebrain to cortical areas in rats

1980 • 447 citations

Neocortical cholinergic innervation: A description of extrinsic and intrinsic components in the rat

1981 • 442 citations

Acetylcholine released from cerebral cortex in relation to state of activation

1966 • 432 citations

Acetylcholinesterase-rich projections from the basal forebrain of the rhesus monkey to neocortex

1976 • 417 citations

The Use of Dopamine β-Hydroxylase as a Marker for the Central Noradrenergic Nervous System in Rat Brain

1972 • 416 citations

The spontaneous and evoked release of acetylcholine from the cerebral cortex

1963 • 386 citations

Adrenergic innervation of pial arteries related to the circle of Willis in the cat

1967 • 383 citations

Behavioral and neurochemical effects following neurotoxic lesions of a major cholinergic input to the cerebral cortex in the rat1

1983 • 371 citations

Laser Doppler measurements of blood flow in capillary tubes and retinal arteries.

1972 • 358 citations

Behavioural, biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats

1987 • 352 citations

CEREBRAL VASODILATOR NERVES AND THEIR PATHWAY FROM THE MEDULLA OBLONGATA

1932 • 336 citations

The latency of activation of neurones in the lateral hypothalamus and substantia innominata during feeding in the monkey

1979 • 314 citations

Learning and memory deficits after lesions of the nucleus basalis magnocellularis: Reversal by physostigmine

1985 • 305 citations

Cortical projection patterns of magnocellular basal nucleus subdivisions as revealed by anterogradely transportedPhaseolus vulgaris leucoagglutinin

1987 • 296 citations

Effects of thyrotropin-releasing hormone (TRH) on the actions of pentobarbital and other centrally acting drugs.

1975 • 292 citations

Observations on the Extrinsic Neural Control of Cerebral Blood Flow in the Baboon

1969 • 279 citations

Dual Adrenergic and Cholinergic Innervation of the Cerebral Arteries of the Rat

1970 • 256 citations

Selective memory loss following nucleus basalis lesions: Long term behavioral recovery despite persistent cholinergic deficiencies

1985 • 247 citations

Brain cholinergic systems

1991 • 240 citations

Changes in cortical acetylcholine output induced by modulation of the nucleus basalis

1986 • 219 citations

Lesions of cholinergic forebrain nuclei: Changes in avoidance behavior and scopolamine actions

1982 • 218 citations

Cortical acetylcholine release and electroencephalographic arousal

1967 • 218 citations

Stimulation of the nucleus basalis of Meynert increases cerebral cortical blood flow in rats

1989 • 216 citations

Aging Decreases Oxidative Metabolism and the Release and Synthesis of Acetylcholine

1981 • 215 citations

Stimulation of the nucleus basalis of Meynert increases acetylcholine release in the cerebral cortex in rats

1989 • 208 citations

Serotonin Neurons Project to Small Blood Vessels in the Brain

1979 • 200 citations

Origin of cholinergic nerves to the rat major cerebral arteries: Coexistence with vasoactive intestinal polypeptide

1985 • 199 citations

Central serotonergic nerves project to the pial vessels of the brain

1983 • 190 citations

In vivo microdialysis - a new approach to the analysis of neurotransmitters in the brain

1987 • 189 citations

Decrease of brain acetylcholine release in aging freely-moving rats detected by microdialysis

1988 • 186 citations

The effects of excitotoxic lesions of the substantia innominata, ventral and dorsal globus pallidus on the acquisition and retention of a conditional visual discrimination: Implications for cholinergic hypotheses of learning and memory

1987 • 183 citations

Acetylcholine release from the cerebral cortex: Its role in cortical arousal

1968 • 178 citations

The effect of septal nuclei stimulation on the release of acetylcholine from the rabbit hippocampus

1975 • 176 citations

Evidence that neural mechanisms do not have important effects on cerebral blood flow.

1978 • 169 citations

Septo-hippocampal and other medial septum-diagonal band neurons: electrophysiological and pharmacological properties

1984 • 168 citations

Repeated measurements of cerebral blood flow in rats. Comparisons between the hydrogen clearance method and laser Doppler flowmetry

1988 • 165 citations

Profound disturbances of spontaneous and learned behaviors following lesions of the nucleus basalis magnocellularis in the rat

1985 • 154 citations

Parasympathetic Control of Coronary Blood Flow in Dogs

1969 • 150 citations

Extracellular Lactic Acid as an Indicator of Brain Metabolism: Continuous On-Line Measurement in Conscious, Freely Moving Rats with Intrastriatal Dialysis

1988 • 146 citations

Selective Electrical Stimulation of Postganglionic Cerebrovascular Parasympathetic Nerve Fibers Originating from the Sphenopalatine Ganglion Enhances Cortical Blood Flow in the Rat

1990 • 145 citations

Adrenergic innervation of the cerebral blood vessels in the rabbit

1971 • 139 citations

Basal forebrain neurons projecting to the rat frontoparietal cortex: Electrophysiological and pharmacological properties

1986 • 138 citations

Effect of Stimulation of the Sphenopalatine Ganglion on Cortical Blood Flow in the Rat

1988 • 138 citations

Electrical stimulation of cerebellar fastigial nucleus increases cerebral cortical blood flow without change in local metabolism: Evidence for an intrinsic system in brain for primary vasodilation

1983 • 130 citations

Origins and Pathways of Choline Acetyltransferase—Positive Parasympathetic Nerve Fibers to Cerebral Vessels in Rat

1990 • 129 citations

Loss of cholinergic neurons in the rat neocortex produces deficits in passive avoidance learning

1983 • 129 citations

Cholinergic modulation of sensory responses in rat primary somatic sensory cortex

1987 • 126 citations

Age and sex-dependent decreases in ChAT in basal forebrain nuclei

1986 • 126 citations

QUANTITATIVE DETERMINATION OF REGIONAL CEREBRAL BLOOD-FLOW IN MAN

1961 • 122 citations

Differential effects on the internal and external carotid circulation of the monkey evoked by locus coeruleus stimulation

1982 • 121 citations

CEREBRAL CIRCULATION

1932 • 118 citations

Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats

1984 • 116 citations

Excitatory effect of acetylcholine on different types of neurons in the first somatosensory neocortex of the rat: Laminar distribution and pharmacological characteristics

1982 • 115 citations

Stability of numbers but not size of mouse forebrain cholinergic neurons to 53 months

1985 • 111 citations

Acetylcholine release from rat cortical slices during postnatal development and aging

1983 • 109 citations

Parasympathetic cholinergic control of cerebral blood flow in dogs.

1977 • 103 citations

Nitric oxide (NO) is involved in increased cerebral cortical blood flow following stimulation of the nucleus basalis of Meynert in anesthetized rats

1992 • 102 citations

Functional landscapes of the dominant hemisphere

1976 • 101 citations

Effect of magnocellular forebrain nuclei lesions on acetylcholine output from the cerebral cortex, electrocorticogram and behaviour.

1982 • 98 citations

The effect of lesions in the locus coeruleus on the physiological responses of the cerebral blood vessels in cats

1977 • 97 citations

Activation of identified septo-hippocampal neurons by noxious peripheral stimulation

1985 • 97 citations

Cortical blood flow increases induced by stimulation of the substancia innominata in the unanesthetized rat

1989 • 94 citations

Effects of stimulation of cervical sympathetic nerves on cortical blood flow and vascular reactivity

1971 • 94 citations

Coronary Vascular Responses to Stimulation of Chemoreceptors and Baroreceptors: EVIDENCE FOR REFLEX ACTIVATION OF VAGAL CHOLINERGIC INNERVATION

1972 • 93 citations

Global cerebral vasodilation by stimulation of rat fastigial cerebellar nucleus

1982 • 92 citations

Determinants of Response of Pial Arteries to Norepinephrine and Sympathetic Nerve Stimulation

1975 • 88 citations

The Distribution and Functional Significance of Sympathetic Vasodilators to the Hind Limbs of the Cat

1948 • 87 citations

Effects of aging on rat cortical presynaptic cholinergic processes

1984 • 85 citations

Effect of thyrotropin releasing hormone (TRH) on acetylcholine release from different brain areas investigated by microdialysis

1991 • 84 citations

Concentration of Noradrenaline in Pial Vessels, Choroid Plexus, and Iris during Two Weeks after Sympathetic Ganglionectomy or Decentralization

1972 • 80 citations

The cholinergic pathway to cerebral blood vessels

1979 • 79 citations

FUNCTIONAL VASODILATION IN THE SUBMANDIBULAR SALIVARY GLAND

1957 • 77 citations

Further characterizations of the nature of the behavioral and neurochemical effects of lesions to the nucleus basalis of meynert in the rat

1985 • 77 citations

Decreased Cortical Glucose Utilization after Ibotenate Lesion of the Rat Ventromedial Globus Pallidus

1984 • 75 citations

Hypercapnia and stimulation of the substantia innominata increase rat frontal cortical blood flow by different cholinergic mechanisms

1991 • 75 citations

Secretion of kallikrein and its role in vasodilatation in the submaxillary gland

1968 • 75 citations

Cholinergic Vasodilator Neryes in the Sympathetic Outflow to the Muscles of the Hind Limbs of the Cat

1948 • 75 citations

Trigeminal fibre collaterals storing substance P and calcitonin gene-related peptide associate with ganglion cells containing choline acetyltransferase and vasoactive intestinal polypeptide in the sphenopalatine ganglion of the rat. An axon reflex modulating parasympathetic ganglionic activity?

1989 • 74 citations

Low frequency stimulation of the locus coeruleus reduces regional cerebral blood flow in the spinalized cat

1989 • 73 citations

Alpha-receptor stimulation by endogenous and exogenous norepinephrine and blockade by phentolamine in pial arteries of cats.

1975 • 72 citations

Age-impaired impulse flow from nucleus basalis to cortex

1985 • 70 citations

TIME COURSE OF EFFECTS OF UNILATERAL LESIONS OF THE NUCLEUS BASALIS OF MEYNERT ON GLUCOSE UTILIZATION BY THE CEREBRAL CORTEX

1989 • 69 citations

Acute effects of high-dose thyrotropin releasing hormone infusions in Alzheimer's disease

1989 • 67 citations

Cortically projecting nucleus basalis neurons in rat are physiologically heterogeneous

1984 • 64 citations

Lesions of the basal forebrain in rat selectively impair the cortical vasodilation elicited from cerebellar fastigial nucleus

1983 • 63 citations

Effects of cholinergic nerves on cerebral blood flow in cats.

1981 • 62 citations

Is there an active mechanism limiting the influence of the sympathetic system on the cerebral vascular bed? Evidence for vasomotor escape from sympathetic stimulation in the rabbit

1979 • 61 citations

In vivo and in vitro studies on the regulation of cholinergic neurotransmission in striatum, hippocampus and cortex of aged rats

1986 • 59 citations

Role of Autonomic Nervous System in Autoregulation of Human Cerebral Circulation

1971 • 59 citations

Thyrotropin-releasing hormone: central site of action in antagonism of pentobarbital narcosis

1979 • 57 citations

Nucleus basalis neurons exhibit axonal branching with decreased impulse conduction velocity in rat cerebrocortex

1985 • 55 citations

Cortical cerebral blood flow governed by the basal forebrain: Age-related Impairments

1991 • 53 citations

Widespread reductions in cerebral blood flow and metabolism elicited by electrical stimulation of the parabrachial nucleus in rat

1985 • 53 citations

Effect of unilateral nucleus basalis lesion on cortical and striatal acetylcholine and dopamine release monitored in vivo with microdialysis

1990 • 52 citations

Thyrotropin‐releasing hormone (TRH) causes sympathetic activation and cerebral vasodilation in the rabbit

1984 • 52 citations

Cerebral blood flow and oxygen consumption in the rat brain after lesions of the noradrenergic locus coeruleus system

1981 • 50 citations

Effect of phosphatidylserine on acetylcholine release and content in cortical slices from aging rats

1987 • 50 citations

Local cerebral glucose utilization following unilateral and bilateral lesions of the nucleus basalis magnocellularis in the rat

1988 • 50 citations

Cutaneous mechanical sensory stimulation increases extracellular acetylcholine release in cerebral cortex in anesthetized rats

1992 • 49 citations

Effect of stimulation of facial nerve on regional cerebral blood flow and glucose utilization in cats

1989 • 48 citations

Stimulation of the nucleus basalis of Meynert and substantia innominata produces widespread increases in cerebral blood flow in the frontal, parietal and occipital cortices

1990 • 47 citations

Effects of Electrical Stimulation of the Dorsal Raphe Nucleus on Local Cerebral Blood Flow in the Rat

1989 • 45 citations

The mechanism of cerebrovascular vasoconstriction in response to locus coeruleus stimulation

1985 • 45 citations

Evidence for a dual innervation affecting local blood flow in the hypothalamus of the conscious rabbit.

1976 • 44 citations

Reaction of pial arteries and veins to sympathetic stimulation in the cat.

1981 • 44 citations

Rats with nucleus basalis magnocellularis lesions mimic mnemonic symptomatology observed in patients with dementia of the Alzheimer's type.

1987 • 44 citations

Stimulation of the septal complex increases local cerebral blood flow in the hippocampus in anesthetized rats

1989 • 43 citations

Effects of TRH on cerebral and peripheral blood flows; role of submesencephalic brain stem centres

1986 • 43 citations

Cutaneous stimulation regulates blood flow in cerebral cortex in anesthetized rats

1990 • 43 citations

Deoxyglucose uptake and choline acetyltransferase activity in cerebral cortex following lesions of the nucleus basalis magnocellularis

1984 • 42 citations

Responses of neurons in the nucleus basalis of Meynert to various afferent stimuli in rats

1990 • 42 citations

Well-maintained responses of acetylcholine release and blood flow in the cerebral cortex to focal electrical stimulation of the nucleus basalis of Meynert in aged rats

1989 • 41 citations

Long lasting suppression of firing of cortical neurons and decrease in cortical blood flow following train pulse stimulation of the locus coeruleus in the cat

1981 • 40 citations

Stimulation of the nucleus basalis of Meynert does not influence glucose utilization of the cerebral cortex in anesthetized rats

1990 • 40 citations

Evidence for central innervation of intracerebral blood vessels: Local cerebral blood flow measurements and histofluorescence analysis by the sucrose-phosphate-glyoxylic acid (SPG) method

1976 • 39 citations

Stimulation of the rostral ventrolateral medullary neurons increases cortical cerebral blood flow via activation of the intracerebral neural pathway

1989 • 38 citations

Effect of stimulation of nucleus raphe dorsalis on carotid blood flow. II. The cat

1985 • 38 citations

Stimulation of the nucleus basalis of Meynert increases cortical cerebral blood flow without influencing diameter of the pial artery in rats

1992 • 37 citations

Rats with nucleus basalis magnocellularis lesions mimic mnemonic symptomatology observed in patients with dementia of the Alzheimer's type.

1987 • 37 citations

Effects of facial nerve section and stimulation on cerebral and ocular blood flow in hemorrhagic hypotension

1981 • 36 citations

Effects of stimulation of cervical sympathetic trunks with various frequencies on the local cortical cerebral blood flow measured by laser doppler flowmetry in the rat.

1990 • 36 citations

The Electroencephalogram, Blood Flow, and Oxygen Uptake in Rabbit Cerebrum

1981 • 35 citations

Short term reactions in the thyroid gland revealed by continuous measurement of blood flow, rate of uptake of radioactive iodine and rate of release of labelled hormones.

1958 • 34 citations

Responses of regional cerebral blood flow following focal electrical stimulation of the nucleus basalis of Meynert and the medial septum using the [14C]iodoantipyrine method in rats

1990 • 33 citations

Chemical stimulation of the rostral ventrolateral medullary pressor area decreases cerebral blood flow in anesthetized rats

1991 • 30 citations

Choline Acetyltransferase Activity Associated with Cerebral Cortical Microvessels Does Not Originate in Basal Forebrain Neurons

1991 • 30 citations

Evidence for a possible role for serotonergic systems in the control of cerebral blood flow

1990 • 29 citations

Effect in cat locus coeruleus lesions on the response of cerebral blood flow and cardiac output to altered paCO2

1986 • 29 citations

Effect of stimulation of the nucleus basalis of Meynert on blood flow and extracellular lactate in the cerebral cortex with special reference to the effect of noxious stimulation of skin and hypoxia

1990 • 29 citations

5-Hydroxytryptamine innervation of vessels in the rat cerebral cortex

1985 • 28 citations

Effect of Stimulation of the Vagus Nerve on the Thyroidal Release of¹³¹I-Labeled Hormones

1968 • 27 citations

Chemical stimulation of the ventrolateral medullary depressor area decreases ipsilateral cerebral blood flow in anesthetized rats

1991 • 26 citations

Cholinergic and VIPergic vasodilator actions of parasympathetic nerves on the thyroid blood flow in rats.

1987 • 26 citations

Role of nucleus basalis in cholinergic control of cortical blood flow

1991 • 26 citations

Comparison between Pial and Intraparenchymal Vascular Responses to Cervical Sympathetic Stimulation in Cats. Part 1. Under Normal Resting Conditions

1986 • 26 citations

Decrease in neostriatal blood flow after d-amphetamine administration or electrical stimulation of the substantia nigra

1977 • 25 citations

Quantitative multiregional blood flow measurements during cervical sympathetic stimulation

1977 • 25 citations

Adrenergic innervation of large cerebral blood vessels of the rabbit studied by fluorescence microscopy. Absence of features that might contribute to non-uniform change in cerebral blood flow.

1977 • 22 citations

Effects of Lesioning of the Substantia Innominata on Autoregulation of Local Cerebral Blood Flow in Rats

1991 • 20 citations

The organization of the salivary gland microcirculation

1977 • 19 citations

Somatosensory Regulation of Regional Hippocampal Blood Flow in Anesthetized Rats.

1992 • 19 citations

Pathologisch-anatomische Untersuchungen : mit Bezug auf die sogenannten Basalganglien und ihre Adnexe

1929 • 19 citations

Brain acetylcholine: An inventory of our knowledge on the 50th anniversary of its discovery

1983 • 18 citations

Contribution of cholinergic vasodilators on the increase in cerebral cortical blood flow responses to the intravenous administration of thyrotropin releasing hormone in anesthetized rats

1988 • 18 citations

Sustained cerebral vasoconstriction during bilateral sympathetic stimulation in anesthetized rabbits

1985 • 16 citations

Parasympathetic Cholinergic Vasodilator Mechanism in the Terminal Liver Microcirculation in Rats

1979 • 15 citations

Lesion of the nucleus basalis magnocellularis does not affect cerebral cortical blood flow in rats

1991 • 14 citations

The role of basal forebrain in the primary cholinergic vasodilation in rat neocortex produced by systemic administration of cismethrin

1988 • 14 citations

Effect of stimulation of nucleus raphe dorsalis on carotid blood flow. I. The monkey

1985 • 13 citations

Responses of regional cerebral blood flow to intravenous administration of thyrotropin releasing hormone in aged rats

1992 • 10 citations

Increased cerebral blood flow during hypercapnia is not affected by lesion of the nucleus locus ceruleus.

1986 • 9 citations

Cerebral blood flow—Physiologic and clinical aspects

1988 • 4 citations

Vasodilator responses in the hippocampus in response to stimulation of the septal complex are well maintained in aged rats

1992 • 2 citations

Stimulation of the substantia nigra increases striatal blood flow in rats

1992 • 2 citations

Nigral-Induced Decrease in Striatal Blood Flow and the Influence on This Decrease of Several Drugs in Reserpinized and Non-Reserpinized Cats

1986 • 2 citations

Deleted Work

1955 • 0 citations