Toxicity of 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD)

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1978 • 1,054 citations

Toxicology of chlorinated dibenzo-p-dioxins.

1973 • 478 citations

In vitro metabolic activation in mutagenesis testing

1976 • 434 citations

The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs

1978 • 387 citations

Teratology studies with 2,4,5-trichlorophenoxyacetic acid and 2,3,7,8-tetrachlorodibenzo-P-dioxin

1971 • 374 citations

Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.

1980 • 374 citations

Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene.

1974 • 293 citations

Trace Chemistries of Fire: A Source of Chlorinated Dioxins

1980 • 285 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): Results of a 13-week oral toxicity study in rats

1976 • 236 citations

Suppression of Cellular Immunity in Rats and Mice by Maternal Treatment with 2, 3, 7, 8-Tetrachlorodibenzo-<i>p</i>-Dioxin

1974 • 234 citations

Three-generation reproduction study of rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet

1979 • 232 citations

Chlorinated dibenzo-p-dioxins and related compounds in incinerator effluents

1980 • 227 citations

Chlorinated dibenzo-p-dioxins and related compounds in incinerator effluents: A review of measurements and mechanisms of formation

1980 • 212 citations

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rhesus monkeys (Macaca mulatta) following a single oral dose

1978 • 167 citations

Study of the teratogenicity of 2,3,7,8-tetrachiorodibenzo-p-dioxin in the rat

1971 • 166 citations

Embryotoxic effects in mice treated with 2,4,5-trichlorophenoxyacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin

1972 • 159 citations

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57B16 mice

1974 • 152 citations

Induction and suppression of hepatic and extrahepatic microsomal foreign-compound-metabolizing enzyme systems by 2,3,7,8-tetrachlorodibenzo-p-dioxin

1975 • 142 citations

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Golden Syrian hamster

1980 • 131 citations

Influence of solvents and adsorbents on dermal and intestinal absorption of TCDD

1980 • 130 citations

An estimate of the maximum in vivo covalent binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to rat liver protein, ribosomal RNA, and DNA.

1979 • 123 citations

TOXICOPATHOLOGY CHARACTERISTICS OF THE HALOGENATED AROMATICS

1979 • 122 citations

A survey on the mutagenicity of various pesticides

1973 • 115 citations

Morphological changes in monkeys consuming a diet containing low levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin

1977 • 110 citations

Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin

1973 • 106 citations

THE SEVESO ACCIDENT: ITS NATURE, EXTENT AND CONSEQUENCES

1979 • 105 citations

Postnatal effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

1973 • 105 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin: Acute oral toxicity in hamsters

1981 • 104 citations

Polychlorodibenzo-p-dioxins: Perinatal Effects and the Dominant Lethal Test in Wistar Rats

1973 • 101 citations

A review of the genetic toxicology of chlorinated dibenzo-p-dioxins

1977 • 100 citations

STUDIES OF THE MECHANISMS OF TOXICITY OF 2,3,7,8‐TETRACHLORODIBENZO‐p‐DIOXIN (TCDD)

1979 • 98 citations

TCDD-induced changes in rat liver microsomal enzymes.

1973 • 95 citations

Teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in CF-1 mice

1976 • 90 citations

Acute human exposure to TCDD in Seveso, Italy

1980 • 84 citations

Carcinogenicity testing of herbicide 2,4,5-trichlorophenoxyethanol containing dioxin and of pure dioxin in Swiss mice

1979 • 74 citations

2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically "nonresponsive" at Ah locus.

1978 • 73 citations

Anticarcinogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene tumor initiation and its relationship to DNA binding.

1979 • 71 citations

Berufliche Vergiftungen bei der Herstellung von Chlorphenol-Verbindungen

1961 • 70 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) effects on hepatic microsomal cytochrome P-448-mediated enzyme activities

1979 • 61 citations

Toxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in larval and adult forms ofRana catesbeiana

1976 • 56 citations

Organ specific induction of drug metabolizing enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat

1978 • 56 citations

Chlorinated phenoxy acids and their dioxins

1979 • 54 citations

Regulation of mitosis: III. cytological effects of 2,4,5-trichloro-phenoxyacetic acid and of dioxin contaminants in 2,4,5-T formulations

1972 • 52 citations

Tumor-initiating ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and arochlor 1254 in the two-stage system of mouse skin carcinogenesis

1977 • 51 citations

Role of the endocrine system in the action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the thymus

1980 • 45 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on mammalian cells in tissue cultures

1975 • 45 citations

Inactivation of Qβ RNA by electrophiles

1973 • 27 citations

Effect of tetrachlorodibenzo-p-dioxin on growth rate and the synthesis of lipids and proteins in rats

1972 • 27 citations

Effects of endrin on telencephalic function in the pigeon

1966 • 23 citations

The Seveso accident

1983 • 17 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on stimulated DNA synthesis in the liver and kidney of the rat

1974 • 15 citations

[Pathological and embryological studies on abortion cases related to the Seveso accident].

1978 • 15 citations

THE TOXICOLOGY OF 2,3,7,8-TETRACHLORODIBENZO- <italic>p</italic> -DIOXIN AND ITS STRUCTURAL ANALOGUES

1979 • 15 citations