Saccharin: A toxicological and historical perspective

Bioassay of Pesticides and Industrial Chemicals for Tumorigenicity in Mice: A Preliminary Note<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1969 • 523 citations

THE MAMMALIAN URINARY BLADDERAN ACCOMMODATING ORGAN

1975 • 389 citations

Chromosome Aberrations and Sister Chromatid Exchanges in Chinese Hamster Cells Exposed to Various Chemicals 2

1977 • 330 citations

Tobacco Use, Occupation, Coffee, Various Nutrients, and Bladder Cancer<xref ref-type="fn" rid="FN2">2</xref>

1980 • 303 citations

The epidemiology of bladder cancer.A second look

1977 • 292 citations

Cancer of the Urinary Bladder Induced in Mice with Metabolites of Aromatic Amines and Tryptophan

1957 • 275 citations

Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis.

1979 • 272 citations

Comprehensive Drug Surveillance

1970 • 247 citations

Long Term and Short Term Screening Assays for Carcinogens: A Critical Appraisal

1981 • 238 citations

Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice.

1973 • 229 citations

Cancer Mortality Among Diabetics<xref ref-type="fn" rid="FN2">2</xref>

1970 • 221 citations

Overview of tumor promotion in animals

1983 • 206 citations

Evaluation of the carcinogenicity of chemicals: a review of the Monograph Program of the International Agency for Research on Cancer (1971 to 1977).

1978 • 186 citations

Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors¹

1950 • 180 citations

Evaluation of a new model to detect bladder carcinogens or co-carcinogens; results obtained with saccharin, cyclamate and cyclophosphamide

1975 • 156 citations

ARTIFICIAL SWEETENERS AND HUMAN BLADDER CANCER

1980 • 152 citations

Long-term toxicity of ortho-toluenesulfonamide and sodium saccharin in the rat

1980 • 150 citations

Mechanisms of Tumor Promotion and Cocarcinogenesis

1979 • 142 citations

Bladder cancer: smoking, beverages and artificial sweeteners.

1974 • 123 citations

ARTIFICIAL SWEETENERS AND HUMAN BLADDER CANCER

1977 • 121 citations

The politics of cancer

1978 • 116 citations

Molecular and Cellular Aspects of Carcinogen Screening Tests

1981 • 113 citations

Conditioned hypoglycemia: A mechanism for saccharin-induced sensitivity to insulin in the rat.

1974 • 109 citations

Inhibition of carbonic anhydrase by sulphonamides

1948 • 108 citations

The Predictive Value of Rodent Carcinogenicity Tests in the Evaluation of Human Risks

1979 • 105 citations

Guidelines for carcinogen bioassay in small rodents.

1976 • 103 citations

Coffee Drinking and Cancer of the Lower Urinary Tract<xref ref-type="fn" rid="fn2">2</xref>

1975 • 102 citations

Chronic toxicity and carcinogenicity to the urinary bladder of sodium saccharin in the in utero-exposed rat

1980 • 100 citations

Saccharin-induced hyperplasia of the rat urinary bladder.

1980 • 99 citations

Artificial Sweeteners and Cancer of the Lower Urinary Tract

1980 • 99 citations

The importance of synergy between weak carcinogens in the induction of bladder cancer in experimental animals and humans.

1977 • 95 citations

A carcinogenicity study of commercial saccharin in the rat

1975 • 95 citations

Life Time Occupation, Smoking, Caffeine, Saccharine, Hair Dyes and Bladder Carcinogenesis

1982 • 93 citations

Dose Response of Saccharin in Induction of Urinary Bladder Hyperplasias in Fischer 344 Rats Pretreated With <italic>N</italic>-Butyl-<italic>N</italic>-(4-hydroxybutyl)nitrosamine<xref ref-type="fn" rid="FN2">2</xref>

1980 • 91 citations

Inter-species comparisons of carcinogenicity

1980 • 87 citations

A Comparison of the Chronic Toxicities of Synthetic Sweetening Agents*

1951 • 85 citations

Saccharin and Other Sweeteners: Mutagenic Properties

1977 • 83 citations

Production of Urinary Bladder Carcinomas in Mice by Sodium Saccharin

1970 • 83 citations

Co-carcinogenic Action of Saccharin in the Chemical Induction of Bladder Cancer

1973 • 82 citations

Bladder cancer mortality in England and Wales in relation to cigarette smoking and saccharin consumption

1974 • 82 citations

Saccharin-Induced Sister Chromatid Exchanges in Chinese Hamster and Human Cells

1978 • 79 citations

Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.

1981 • 79 citations

Scientific Bases for Identification of Potential Carcinogens and Estimation of Risks

1979 • 79 citations

Chemical Carcinogens: How Dangerous Are Low Doses?

1978 • 77 citations

Artificial Sweetener Use and Bladder Cancer: A Case-Control Study

1980 • 77 citations

Bladder cancer mortality in diabetics in relation to saccharin consumption and smoking habits.

1975 • 76 citations

Saccharin as a sugar surrogate.

1967 • 76 citations

Further Tests for Tumour-Initiating Activity: N,N-DI-(2-Chloroethyl)-P-Aminophenylbutyric Acid (CB1348) as an Initiator of Skin Tumour Formation in the Mouse

1956 • 74 citations

Scanning electron microscopic examination of reversible hyperplasia of the rat urinary bladder.

1981 • 73 citations

Saccharin, Cyclamate, and Human Bladder Cancer

1978 • 72 citations

Saccharin does not bind to DNA of liver or bladder in the rat

1977 • 72 citations

The effect of sodium saccharin in the diet on caecal microflora

1980 • 72 citations

Saccharin may act as a tumour promoter by inhibiting metabolic cooperation between cells

1980 • 71 citations

Enhancement of Oncogenesis in C3H/10T1/2 Mouse Embryo Cell Cultures by Saccharin

1978 • 70 citations

Cancer and diabetes mellitus a review of the literature

1971 • 69 citations

Saccharin: An epigenetic carcinogen/mutagen?

1978 • 67 citations

Potentiation of insulin coma by saccharin.

1965 • 66 citations

Response of the rat to saccharin with particular reference to the urinary bladder

1979 • 64 citations

The tissue distribution and pharmacokinetics of saccharin in the rat

1980 • 61 citations

Relative importance of risk factors in bladder carcinogenesis

1978 • 61 citations

Long term toxicity and reproduction study (including a teratogenicity study) with cyclamate, saccharin and cyclohexylamine

1977 • 60 citations

IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans:

1984 • 60 citations

Toward a classification scheme for degrees of experimental evidence for the carcinogenicity of chemicals for animals.

1980 • 59 citations

Role of ATP in respiratory control and active transport in tobacco hornworm midgut

1980 • 56 citations

The Fate of [¹⁴C]Saccharin in Man, Rat and Rabbit and of 2-Sulphamoyl[¹⁴C]benzoic Acid in the Rat

1977 • 54 citations

Dose‐dependent fate of 1,4‐dioxane in rats

1978 • 53 citations

Synthetic Sweetener Consumption and Bladder Cancer Trends in the United States

1970 • 53 citations

The epidemiology of bladder cancer in West Yorkshire. A preliminary report on non-occupational aetiologies

1981 • 53 citations

Cancer mortality and saccharin consumption in diabetics.

1976 • 52 citations

Effect of dose of sodium saccharin on the induction of rat urinary bladder proliferation.

1981 • 51 citations

Chemical Carcinogens: The Scientific Basis for Regulation

1978 • 51 citations

The mutagenicity of saccharin

1975 • 48 citations

The metabolism of saccharin in laboratory animals

1973 • 47 citations

Promotion in urinary bladder carcinogenesis.

1983 • 46 citations

The metabolism of saccharin in animals

1975 • 45 citations

Feeding studies on sodium cyclamate, saccharin and sucrose for carcinogenic and tumour-promoting activity

1970 • 44 citations

Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally

1981 • 44 citations

The pharmacokinetics of saccharin in man

1981 • 44 citations

The scientific basis of health and safety regulation

1982 • 43 citations

Comprehensive drug surveillance

1970 • 43 citations

Sucrose Consumption Early in Life Fails to Modify the Appetite of Adult Rats for Sweet Foods

1979 • 39 citations

Non-nutritive Sweeteners and Human Bladder Cancer: Preliminary Findings

1976 • 39 citations

The effects of saccharin on the metabolism of dietary tryptophan to indole, a known cocarcinogen for the urinary bladder of the rat

1983 • 39 citations

Toxicological studies with sodium cyclamate and saccharin

1968 • 39 citations

Cancer testing technology and saccharin

1978 • 38 citations

Environmental pollution and carcinogenic risks

1977 • 36 citations

Response of male rats to sodium saccharin ingestion: Urine composition and mineral balance

1979 • 36 citations

Artificial sweeteners and bladder cancer in Manchester, U.K., and Nagoya, Japan

1982 • 35 citations

Carcinogenicity of saccharin.

1978 • 34 citations

Saccharin Metabolism and Tumorigenicity

1979 • 34 citations

Intra‐uterine exposure to saccharine and risk of bladder cancer in man

1982 • 34 citations

Metabolic fate of saccharin in the albino rat

1972 • 33 citations

An independent analysis of the National Cancer Institute study on non-nutritive sweeteners and bladder cancer.

1982 • 32 citations

Excretion and metabolism of saccharin in man. II. Studies with 14C-labelled and unlabelled saccharin

1974 • 32 citations

Effect of amaranth, Ponceau 4R and/or vitamin A on enzyme activities of the rat liver

1978 • 32 citations

Cell culture tumor promotion experiments with saccharin, phorbol myristate acetate and several common food materials

1980 • 31 citations

Stimulation of DNA synthesis in calcium-deprived T51B liver cells by the tumor promoters phenobarbital, saccharin, and 12-O-tetradecanoylphorbol-13-acetate.

1980 • 31 citations

Saccharin. Distribution and excretion of a limited dose in the rat

1973 • 31 citations

In utero exposure in chronic toxicity/carcinogenicity studies

1981 • 29 citations

Genetic Effects of Impure and Pure Saccharin in Yeast

1979 • 29 citations

The Metabolism of Saccharin and the Related Compounds in Rats and Guinea Pigs

1972 • 28 citations

Mutagenicity study of remsen-fahlberg saccharin and contaminants

1980 • 28 citations

Specially designed sweeteners and food for diabetics—a real need?

1976 • 28 citations

Effect of sodium saccharin and L-tryptophan on rat urine during bladder carcinogenesis.

1981 • 26 citations

Maintenance by saccharin of membrane alterations of rat bladder cells induced by subcarcinogenic treatment with bladder carcinogens.

1981 • 26 citations

Hypoglycemic Effects of Saccharin in Experimental Animals

1959 • 26 citations

Ortho-toluene sulphonamide and saccharin in the promotion of bladder cancer in the rat

1980 • 25 citations

Effects of Sodium Saccharin and Caffeine on the Urinary Bladder of Rats Treated with N-Butyl-N-(4-Hydroxybutyl)Nitrosamine

1980 • 25 citations

The influence of ammonium chloride on the induction of bladder tumours by 4-ethylsulphonylnaphthalene-1-sulphonamide

1975 • 25 citations

Placental transmission and fetal distribution of saccharin

1971 • 25 citations

A chronic study of artificial sweeteners in Syrian golden hamsters

1975 • 24 citations

Mutagenicity of saccharin in drosophila: The possible role of contaminants

1977 • 23 citations

Non-Caloric Sweeteners and Weight Reduction

1956 • 22 citations

Relative Risks of Saccharin and Calorie Ingestion

1978 • 20 citations

Possible mutagenic activity of saccharin

1979 • 19 citations

A Preliminary Report on the Pharmacokinetics of Saccharin in Man: Single Oral Dose Administration

1981 • 19 citations

Toxicology studies. II. The laboratory animal

1979 • 19 citations

Einfluß einer mehrwöchigen Behandlung männlicher und weiblicher Mäuse mit Saccharin, Cyclamat oder Cyclohexylaminsulfat auf Fertilität und Dominant-Letal-Effekte

1975 • 19 citations

The Influence of Saccharin on the Blood‐Sugar

1950 • 19 citations

No synergism between caffeine and saccharin in the induction of sister chromatid exchange in human lymphocytes

2009 • 18 citations

A DUAL TASTE FOR SACCHARIN IN THE RAT

1977 • 18 citations

Symposium on the evaluation of the safety of food additives and chemical residues: II. The role of the laboratory animal study of intermediate duration for evaluation of safety

1970 • 17 citations

Syncarcinogenic action of saccharin or sodium cyclamate in the induction of bladder tumours in MNU-pretreated rats

1980 • 17 citations

The effect of orthotoluenesulfonamide and sodium saccharin on the urinary tract of neonatal rats

1979 • 17 citations

Long-term administration of artificial sweeteners to the rhesus monkey (M. Mulatta)

1975 • 17 citations

Effects of Sodium Cyclamate on the Growth of Rats compared with other Variations in the Diet

1969 • 17 citations

Spontaneous abortion and the use of sugar substitutes (saccharin)

1978 • 17 citations

Studies to evaluate artificial sweeteners, especially Remsen-Fahlberg saccharin, and their possible impurities, for potential mutagenicity by the Salmonella/mammalian liver microsome test

1981 • 17 citations

Tissue levels of saccharin in the rat during two-generation feeding studies

1982 • 16 citations

Benefits of saccharin: A review

1978 • 16 citations

Renal tubular transport of saccharin.

1978 • 16 citations

Dominant lethal test in the mouse for mutagenic effects of saccharine

1973 • 16 citations

Saccharin inhibits guanylate cyclase activity: Possible relationship to carcinogenesis

1978 • 16 citations

The inhibition of urease and proteases by sodium saccharin

1982 • 16 citations

Pharmacokinetics of saccharin in the rat. Renal clearance in vivo and in the isolated perfused kidney.

1980 • 15 citations

Sucrose Solution vs. No-Calorie Sweetener vs. Water in Weight Gain1

1971 • 15 citations

Saccharin use and sugar intake by college students

1980 • 14 citations

Sacchamn effects on the urinary physiology and urothelium of the rat when administered in diet or drinking water

1981 • 14 citations

Biological effects of saccharin ingestion in rats: A preliminary report

1969 • 14 citations

Saccharin, cyclamate, and human bladder cancer. No evidence of an association

1978 • 14 citations

The failure of chronically administered saccharin to stimulate bladder epithelial DNA synthesis in F0 rats

1981 • 13 citations

The absorption of saccharin from the rat urinary bladder

1979 • 13 citations

An overview of the problem of thresholds for chemical carcinogens.

1979 • 13 citations

Non-mutagenicity of saccharin

1978 • 13 citations

The role of laboratory animal studies in estimating carcinogenic risks for man.

1979 • 13 citations

Three Cases of Human Bladder Cancer Following High Dose Cyclamate Ingestion

1977 • 13 citations

Experiments on the carcinogenic effect of ortho-toluol-sulfonamid (OTS)

1978 • 12 citations

The sweet tooth.

1972 • 12 citations

Carcinogenesis testing of saccharin. No transformation or increased sister chromatid exchange observed in two mammalian cell systems

1979 • 12 citations

Effects of saccharin on primary humoral antibody production in rats

1981 • 12 citations

Induction of dominant lethals in mice by sodium saccharin.

1972 • 11 citations

Effects of caffeine and saccharin on DNA in the bladder epithelium of rats treated with N-butyl-N-(3-carboxypropyl)-nitrosamine

1980 • 11 citations

Saccharin: the risks and benefits

1978 • 11 citations

Effect of commercial saccharin preparations on urethan-induced lung tumorigenesis in strain A mice.

1980 • 11 citations

Saccharin use and sugar intake by college students.

1980 • 10 citations

Absorption of Saccharin from Rat Urinary Bladder

1978 • 10 citations

Subacute toxicity studies with sodium saccharin and two hydrolytic derivatives

1976 • 9 citations

Evaluation of renal function in saccharin treated rats

1981 • 9 citations

Absence of mutagenic activity in Salmonella typhimurium of some impurities found in saccharin

1979 • 8 citations

Do Non-Caloric Sweeteners Aid Patients with Diabetes to Adhere to Their Diets?

1965 • 8 citations

The Use of the Syrian Hamster in Toxicology Studies, with Emphasis on Carcinogenesis Bioassay

2015 • 8 citations

Use of Artificial Sweeteners by Cancer Patients<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1979 • 8 citations

The apparent inhibition of urothelial DNA synthesis in neonatal rats by dietary saccharin

1981 • 7 citations

Application of the results of carcinogen bioassays to man.

1976 • 7 citations

Effect of saccharin and sucrose on the performance of young pigs.

1961 • 7 citations

News Feature

1977 • 6 citations

On the mutagenicity of artificial sweeteners and their main impurities

1980 • 6 citations

The exposure of fetal and suckling rats to saccharin from dosed maternal animals

1979 • 6 citations

THE INFLUENCE OF SACCHARIN ON THE DIGESTIVE ENZYMES.

1905 • 6 citations

THE POTENTIATION OF INSULIN BY SULPHONES

1948 • 5 citations

Saccharin—the risks and benefits

1978 • 5 citations

The Fate of [14C]Saccharin in Rats Chronically Fed on Saccharin

1974 • 5 citations

On the mutagenicity of artificial sweeteners and their main impurities examined in the Salmonella/microsome test

1980 • 5 citations

An Experience With Artificial Sweeteners

1965 • 5 citations

The inhibition by saccharin and cyclamate of phosphotransferase and phosphohydrolase activities of glucose-6-phosphatase

1974 • 5 citations

Long-Term Studies on the Potential Carcinogenicity of Artificial Sweeteners in Non-Human Primates

2015 • 5 citations

Effect of simultaneous administration of saccharin or cyclamate and a nitrosamide (MNU) on bladder epithelium and the dominant lethal test

1979 • 5 citations

Nitrates and Nitrites in the Human Diet

1978 • 5 citations

Consumer Beware! Your Food and What's Been Done to It.

1972 • 5 citations

Validation of tests for carcinogenicity.

1980 • 4 citations

Hat Saccharin bei seiner oralen Anwendung Einfluß auf den Blutzucker?

1935 • 4 citations

JUNCTION POTENTIALS IN RESPONSE TO ORTHO- AND ANTI-DROMIC STIMULATION OF HYPOGASTRIC NERVE IN MOUSE VAS DEFERENS

1975 • 4 citations

Food pollution: The violation of our inner ecology

1972 • 4 citations

Calculation of potential bias in the odds ratio illustrated by a study of saccharin use and bladder cancer

1982 • 3 citations

Long-term toxicity study of sodium cyclamate and saccharin sodium in rats

1975 • 3 citations

Studies on the Teratogenicity of Food Additives (1)

1973 • 3 citations

Inhibition by saccharin of glucose-6-phosphatase: effects of alloxan in vivo and deoxycholate in vitro

1976 • 3 citations

THE DANGER OF SACCHARINE

1915 • 3 citations

Saccharin — A European assessment a report

1973 • 3 citations

Co-Carcinogenicity Testing of Saccharin and DL-Tryptophan Following Oral Initiation with N-[4-(5-Nitro-2-furyl)-2-thiazolyl] formamide

2015 • 3 citations

THE INFLUENCE OF SACCHARIN ON THE CATALASES OF THE BLOOD

1920 • 3 citations

Drugs: Cyclamates Farce not appreciated

1970 • 2 citations

BRONX DERMATOLOGICAL SOCIETY

1956 • 2 citations

An experience with artificial sweeteners

1965 • 2 citations

Unmatured science and government regulation

1976 • 2 citations

Saccharin and Bladder Cancer-Reply

1979 • 1 citations

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