Diabetes and Its Relationship to Pancreatic Carcinoma

Hepatogastroenterology

2012 • 1,678 citations

Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

2001 • 788 citations

Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer

1999 • 398 citations

Prevention of pancreatic cancer induction in hamsters by metformin

2001 • 331 citations

Progression of Pancreatic Intraductal Neoplasias to Infiltrating Adenocarcinoma of the Pancreas

1998 • 307 citations

Dietary and Nutritional Factors and Pancreatic Cancer: a Case-Control Study Based on Direct Interviews

1998 • 263 citations

Improved glucose metabolism after subtotal pancreatectomy for pancreatic cancer

1993 • 236 citations

Islet Amyloid Polypeptide in Patients with Pancreatic Cancer and Diabetes

1994 • 234 citations

Pancreatic cancer is associated with impaired glucose metabolism.

1993 • 219 citations

Pancreatic cancer, alcohol, diabetes mellitus and gall‐bladder disease

1989 • 202 citations

Nestin-Expressing Cells in the Pancreatic Islets of Langerhans

2000 • 164 citations

Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas

1998 • 161 citations

Is profound peripheral insulin resistance in patients with pancreatic cancer caused by a tumor-associated factor?

1993 • 140 citations

Cancer of the pancreas induced in the Syrian golden hamster.

1974 • 137 citations

A prospective study of glucose tolerance, insulin, C-peptide, and glucagon responses in patients with pancreatic carcinoma

1978 • 113 citations

Islet cells as a component of pancreatic ductal neoplasms. I. Experimental study: ductular cells, including islet cell precursors, as primary progenitor cells of tumors.

1978 • 112 citations

Transdifferentiation of human islets to pancreatic ductal cells in collagen matrix culture

1996 • 112 citations

Epidemiology of Pancreatic Cancer in Japan

1989 • 102 citations

Islet cell neogenesis in the pancreas

1996 • 102 citations

The time of occurrence of liver metastasis in carcinoma of the pancreas

1995 • 100 citations

Patterns of growth and metastases of induced pancreatic cancer in relation to the prognosis and its clinical implications

1991 • 98 citations

Pancreatic ductal adenocarcinomas induced in syrian hamsters by N‐nitrosobis (2‐oxopropyl) amine contain a c‐Ki‐ras oncogene with a point‐mutated codon 12

1990 • 97 citations

Pancreatic neoplasms in an animal model: Morphological, biological, and comparative studies

1975 • 92 citations

PANCREATIC CANCER

2001 • 79 citations

Putative Pancreatic Cancer-Associated Diabetogenic Factor: 2030 MW Peptide

2002 • 77 citations

Transdifferentiation of Human Islet Cells in a Long-term Culture

2001 • 76 citations

Diabetes mellitus in pancreatic cancer follow-up.

1994 • 72 citations

Cancer and diabetes mellitus a review of the literature

1971 • 69 citations

Endocrine Aspects of Exocrine Cancer of the Pancreas:Their Patterns and Suggested Biologic Significance

1993 • 69 citations

Islet Hormone Secretion in Pancreatic Cancer Patients with Diabetes

1997 • 62 citations

Expression of Neural Cell Adhesion Molecule in Pancreatic Cancer

2001 • 59 citations

Enhancement of pancreatic carcinogenesis in hamsters fed a high-fat diet ad libitum and at a controlled calorie intake.

1989 • 56 citations

Histologic and biologic patterns of microscopic pancreatic ductal adenocarcinomas detected incidentally at autopsy

1998 • 56 citations

Experimental evidence for the origin of ductal-type adenocarcinoma from the islets of Langerhans.

1997 • 55 citations

Peptide Contents of Neuropeptide Y, Vasoactive Intestinal Polypeptide, andβ-Calcitonin Gene-Related Peptide and Their Messenger Ribonucleic Acids after Dexamethasone Treatment in the Isolated Rat Islets of Langerhans

1991 • 53 citations

Stimulation of islet cell proliferation enhances pancreatic ductal carcinogenesis in the hamster model.

1996 • 52 citations

Influence of diabetes on susceptibility to experimental pancreatic cancer

1988 • 44 citations

Species Differences in the Distribution of Drug-Metabolizing Enzymes in the Pancreas

2002 • 41 citations

Mucinous islet cell (amphicrine) carcinoma of the pancreas associated with watery diarheaand hypokalemia syndrome

1988 • 37 citations

Differentiation of Islet Cells in Long-Term Culture

2000 • 36 citations

Induction of adenocarcinoma from hamster pancreatic islet cells treated with N-nitrosobis(2-oxopropyl)amine in vitro

1999 • 36 citations

Comparison of p53 protein expression and cellular localization in human and hamster pancreatic cancer cell lines

1993 • 33 citations

Inhibition of insulin secretion, but normal peripheral insulin sensitivity, in a patient with a malignant endocrine pancreatic tumour producing high amounts of an islet amyloid polypeptide-like molecule

1993 • 30 citations

Glucose tolerance and insulin secretion in experimental pancreatic cancer in the Syrian hamster

1993 • 30 citations

Expression of human tumor-associated antigens in pancreatic cancer induced in Syrian hamsters.

1990 • 30 citations

Importance of diabetes in inhibition of pancreatic cancer by streptozotocin

1989 • 29 citations

Neuroendocrine Differentiation in Pancreatic Duct Carcinoma Special Emphasis on Duct-Endocrine Cell Carcinoma of the Pancreas

1996 • 27 citations

Pancreatic carcinogenicity of N-nitrosobis(2-oxopropyl)-amine in diabetic and non-diabetic Chinese hamsters

1987 • 26 citations

Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16INK4a and p15INK4b cDNAs and their homozygous gene deletion in cheek pouch and pancreatic tumor cells

2001 • 24 citations

Diagnosis of pancreatic cancer

1991 • 24 citations

Early changes in islet hormone secretion in the hamster pancreatic cancer model

2000 • 24 citations

Morphologic characteristics of pancreatic carcinoma with diabetes mellitus

1989 • 23 citations

Cancer epidemiology in Japan.

1979 • 22 citations

A Factor from Pancreatic and Colonic Cancer Cells Stimulates Glucose Uptake and Lactate Production in Myoblasts

1999 • 21 citations

K-ras and p53 mutations in hamster pancreatic ductal adenocarcinomas and cell lines.

1996 • 20 citations

Biologic instability of pancreatic cancer xenografts in the nude mouse

2000 • 20 citations

Abnormal Differentiation of Islet Cells in Pancreatic Cancer

2001 • 19 citations

Alteration of the Langerhans Islets in Pancreatic Cancer Patients

2000 • 18 citations

Increased Expression of Glutathione S-Transferase-π in the Islets of Patients with Primary Chronic Pancreatitis But Not Secondary Chronic Pancreatitis

2001 • 18 citations

In vivo glucose-stimulated amylin secretion is increased in nondiabetic patients with pancreatic cancer

2001 • 17 citations

The Pattern of Xenobiotic-Metabolizing Enzymes in the Human Pancreas

2002 • 15 citations

Pattern of thyrotropin-releasing hormone secretion from the adult and neonatal rat pancreas: comparison with insulin secretion.

1992 • 15 citations

Morphometrical quantitation of pancrearic endocrine cells in patients with carcinoma of the pancreas.

1983 • 14 citations

Modification of Pancreatic Carcinogenesis in the Hamster Model. X. Effect of Streptozotocin<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 12 citations

In vitro pancreatic carcinogenesis

1999 • 12 citations

Cancer Epidemiology in Japan

1979 • 11 citations

Glucose-induced secretion of ACTH-like products by rat pancreatic islets

1994 • 8 citations

Pattern of thyrotropin-releasing hormone secretion from the adult and neonatal rat pancreas: comparison with insulin secretion

1992 • 7 citations

Untitled

1999 • 6 citations

SUETONIUS’ VESPASIAN

2002 • 4 citations

The pattern xenobiotic-metabolising enzymes in the human pancreas

2002 • 1 citations