Site-specific incorporation of biophysical probes into proteins.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

TIME-RESOLVED FLUORESCENCE OF PROTEINS

1985 • 769 citations

Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding.

1987 • 738 citations

Ultraviolet fluorescence of the aromatic amino acids

1957 • 734 citations

Rotational Brownian Motion and Polarization of the Fluorescence of Solutions

1953 • 575 citations

Structural Basis of Amino Acid α Helix Propensity

1993 • 467 citations

STRUCTURAL AND GENETIC ANALYSIS OF PROTEIN STABILITY

1993 • 455 citations

NEW PHOTOLABELING AND CROSSLINKING METHODS

1993 • 446 citations

Structure of bacteriophage T4 lysozyme refined at 1.7 Å resolution

1987 • 349 citations

Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle.

1986 • 337 citations

5′–3′ Exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesis

1988 • 336 citations

Effects of surrounding sequence on the suppression of nonsense codons

1983 • 291 citations

A signal sequence receptor in the endoplasmic reticulum membrane

1987 • 291 citations

p-Benzoyl-L-phenylalanine, a new photoreactive amino acid. Photolabeling of calmodulin with a synthetic calmodulin-binding peptide.

1986 • 221 citations

Context effects: Translation of UAG codon by suppressor tRNA is affected by the sequence following UAG in the message

1983 • 211 citations

Similar Hydrophobic Replacements of Leu99 and Phe153 within the Core of T4 Lysozyme Have Different Structural and Thermodynamic Consequences

1993 • 200 citations

Site-Specific Incorporation of Novel Backbone Structures into Proteins

1992 • 189 citations

[15] Biosynthetic method for introducing unnatural amino acids site-specifically into proteins

1991 • 173 citations

Probing Protein Stability with Unnatural Amino Acids

1992 • 158 citations

Construction of Escherichia coli amber suppressor tRNA genes

1990 • 155 citations

Probing the Structure and Mechanism of Ras Protein with an Expanded Genetic Code

1993 • 130 citations

Kinetic studies of Escherichia coli elongation factor Tu-guanosine 5'-triphosphate-aminoacyl-tRNA complexes

1985 • 100 citations

Mischarging Escherichia coli tRNAPhe with L-4'-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenylalanine, a photoactivatable analog of phenylalanine

1988 • 97 citations

Probing the Mechanism of Staphylococcal Nuclease with Unnatural Amino Acids: Kinetic and Structural Studies

1993 • 80 citations

Semisynthetic Peptides and Protein

1981 • 74 citations

The Effect of Amino Acid Analogues on Alkaline Phosphatase Formation in Escherichia coli K-12

1968 • 65 citations

Photophysics of tryptophan in bacteriophage T4 lysozymes

1990 • 64 citations

The role of cysteine oxidation in the thermal inactivation of T4 lysozyme

1987 • 58 citations

PREPARATION OF SOME NEW BIPHENYLISOPROPYLOXYCARBONYL AMINO ACIDS AND THEIR APPLICATION TO THE SOLID PHASE SYNTHESIS OF A TRYPTOPHAN‐CONTAINING HEPTAPEPTIDE OF BOVINE PARATHYROID HORMONE

1969 • 50 citations

[Nitroxides. 23. Preparation of amino acid free radicals and their complex salts].

1967 • 19 citations