Breakdown of Th Cell Immune Responses and Steroidogenic CYP11A1 Expression in CD4+ T Cells in a Murine Model Implanted with B16 Melanoma

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro.

1996 • 493 citations

Distinct Role of Antigen-Specific T Helper Type 1 (Th1) and Th2 Cells in Tumor Eradication in Vivo

1999 • 445 citations

Steroid production in the thymus: implications for thymocyte selection.

1994 • 351 citations

Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes.

1997 • 349 citations

A direct role for IFN-gamma in regulation of Th1 cell development.

1996 • 304 citations

TGF-beta contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice.

1996 • 274 citations

Regulation of T‐Cell Activation; Differences among T‐Cell Subsets

1989 • 271 citations

The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells

1993 • 265 citations

Inhibition of Th1 Immune Response by Glucocorticoids: Dexamethasone Selectively Inhibits IL-12-Induced Stat4 Phosphorylation in T Lymphocytes

2000 • 255 citations

Corticosteroids Enhance the Capacity of Macrophages to Induce Th2 Cytokine Synthesis in CD4+ Lymphocytes by Inhibiting IL-12 Production

1998 • 240 citations

Differential Regulation of Interleukin-10 (IL-10) and IL-12 by Glucocorticoids In Vitro

1998 • 203 citations

Experimental cancer cachexia induced by transplantable colon 26 adenocarcinoma in mice.

1990 • 194 citations

A Pathogenic Role of Th2 Cells and Their Cytokine Products on the Pulmonary Metastasis of Murine B16 Melanoma

1998 • 166 citations

Gene-Modified Tumor Vaccine with Therapeutic Potential Shifts Tumor-Specific T Cell Response from a Type 2 to a Type 1 Cytokine Profile

1998 • 154 citations

Hormonal Regulation of Cytochrome P450 Enzymes, Cholesterol Side-Chain Cleavage and 17α-Hydroxylase/C17 – 20 Lyase in Leydig Cells1

1990 • 134 citations

Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.

1997 • 132 citations

IL-12 inhibits IL-4 synthesis in keyhole limpet hemocyanin-primed CD4+ T cells through an effect on antigen-presenting cells.

1995 • 67 citations

Interferon-γ Inhibits the Steroidogenic Acute Regulatory Protein Messenger Ribonucleic Acid Expression and Protein Levels in Primary Cultures of Rat Leydig Cells*

1998 • 66 citations

Preimplantation mouse blastocysts fail to express CYP genes required for estrogen biosynthesis

1996 • 45 citations

Th2-like response and antitumor effect of anti-interleukin-4 mAb in mice bearing renal cell carcinoma

1997 • 38 citations

Induction of resistance to active experimental allergic encephalomyelitis by myelin basic protein-specific Th2 cell lines generated in the presence of glucocorticoids and IL-4

2000 • 33 citations

An immunomodulatory arabinomannan extracted from Mycobacterium tuberculosis, Z-100, restores the balance of Th1/Th2 cell responses in tumor bearing mice

1999 • 28 citations

Hormonal changes following tumor transplantation: Factors increasing corticosterone and the relationship of corticosterone to tumor‐induced anti‐inflammation

1988 • 17 citations

Cocaine-Induced Release of Corticosterone Mediates Differential Effects on T-Helper1 and T-Helper2 Cell Responses

1998 • 9 citations