Zolantidine (SK&F 95282) is a potent selective brain‐penetrating histamine H₂‐receptor antagonist

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

Multiple receptors for dopamine

1979 • 3,739 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

Definition and Antagonism of Histamine H2-receptors

1972 • 2,284 citations

Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor

1983 • 1,548 citations

Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding.

1977 • 1,246 citations

Enzyme changes in neonatal skeletal muscle: effect of thyroid deficiency

1978 • 1,103 citations

Psychopharmacology: A Generation of Progress

1979 • 1,101 citations

Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decar☐ylase as a marker

1984 • 813 citations

Cimetidine—A Non-Thiourea H₂-Receptor Antagonist

1975 • 449 citations

Binding characteristics of 3H-prazosin to rat brain α-adrenergic receptors

1979 • 419 citations

Histamine and noradrenaline decrease calcium-activated potassium conductance in hippocampal pyramidal cells

1983 • 413 citations

Characteristics of GABA_B receptor binding sites on rat whole brain synaptic membranes

1983 • 377 citations

Characteristics of GABA_B receptor binding sites on rat whole brain synaptic membranes

1997 • 294 citations

Histamine as a Neurotransmitter in Mammalian Brain: Neurochemical Evidence

1980 • 284 citations

Brain histamine receptors as targets for antidepressant drugs

1978 • 258 citations

Tricyclic antidepressant drugs block histamine H2 receptor in brain

1977 • 231 citations

Inhibition of Histamine Synthesis in Brain by α‐Fluoromethylhistidine, a New Irreversible Inhibitor: In Vitro and In Vivo Studies

1980 • 231 citations

Methods in Biogenic Amine Research

1984 • 231 citations

Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine.

1978 • 230 citations

Histamine-sensitive adenylate cyclase in mammalian brain

1976 • 218 citations

Regulation of serotonin2 (5-HT2) receptors labeled with [3H]spiroperidol by chronic treatment with the antidepressant amitriptyline.

1980 • 207 citations

Comparison of the pharmacological characteristics of 5 HT1 and 5 HT2 binding sites with those of serotonin autoreceptors which modulate serotonin release

1982 • 200 citations

Regional distribution of mast cells containing histamine, dopamine, or 5‐hydroxytryptamine in the mammalian brain

1977 • 189 citations

[3H]rauwolscine and [3H]yohimbine binding to rat cerebral and human platelet membranes: Possible heterogeneity of α2-adrenoceptors

1982 • 184 citations

THE BINDING OF [³H]MEPYRAMINE TO HISTAMINE H₁ RECEPTORS IN GUINEA‐PIG BRAIN

1978 • 170 citations

The mast cells of the mammalian central nervous system

1974 • 162 citations

Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex

1983 • 159 citations

Studies on a Capillary-Rich Fraction Isolated from Brain: Histaminic Components and Characterization of the Histamine Receptors Linked to Adenylate Cyclase

1980 • 152 citations

Chemistry and Structure—Activity Relationships of Drugs Acting at Histamine Receptors

1982 • 133 citations

Mast cells in rat thalamus: Nuclear localization, sex difference and left-right asymmetry

1984 • 115 citations

Histamine turnover in regions of rat brain

1984 • 95 citations

Pharmacological characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in slices from guinea-pig hippocampus.

1978 • 94 citations

3H-Glycogen hydrolysis elicited by histamine in mouse brain slices: selective involvement of H1 receptors.

1980 • 89 citations

Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide.

1977 • 89 citations

Turnover of histamine in rat brain and its decrease under barbiturate anesthesia.

1974 • 84 citations

Biochemical indentification of the mammalian muscarinic cholinergic receptor.

1975 • 83 citations

Effect of α‐Fluoromethylhistidine on the Histamine Content of the Brain of W/W^v Mice Devoid of Mast Cells: Turnover of Brain Histamine

1983 • 73 citations

Pharmacological characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in slices from guinea-pig hippocampus.

1978 • 72 citations

Cerebral Histamine: Indications for Neuronal and Vascular Regulation

1982 • 72 citations

Histamine turnover in rat brain

1974 • 70 citations

The dilating effect of histamine on pial arteries of cats and its mediation by H2 receptors.

1979 • 66 citations

Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H₁‐receptor antagonist with negligible ability to penetrate the central nervous system

1986 • 61 citations

Histamine Receptors in the Brain and Their Possible Functions

1982 • 57 citations

Pharmacological specificity of brain histamine H2-receptors differs in intact cells and cell-free preparations

1980 • 55 citations

IN VIVO FORMATION AND CATABOLISM OF [¹⁴C]HISTAMINE IN MOUSE BRAIN

1970 • 54 citations

Histamine-induced inositol phospholipid breakdown mirrors H1-receptor density in brain

1983 • 51 citations

Histamine Turnover in the Brain of Different Mammalian Species: Implications for Neuronal Histamine Half‐Life

1984 • 49 citations

Pharmacological properties of histamine-sensitive adenylate cyclase from mammalian brain.

1979 • 45 citations

Characterization of histamine receptors in cat cerebral arteries in vitro and in situ.

1983 • 37 citations

Isolated Brain Microvessels: Preparation, Morphology, Histamine and Catecholamine Contents

1980 • 36 citations

The interaction of histamine and guanylnucleotides with cardiac adenylate cyclase and its relationship to cardiac contractility.

1977 • 29 citations

Pharmacological assay of cardiac H2-receptor blockade by amitriptyline and lysergic acid diethylamide.

1980 • 27 citations

l-Histidine Decarboxylase in the Human Brain: Properties and Localization

1980 • 23 citations

Histamine H2-binding studies in the guinea-pig brain

1984 • 21 citations

Normal levels of histamine and Tele-Methylhistamine in mast cell-deficient mouse brain

1984 • 15 citations

Response of the histamine h2-receptor in brain to antidepressant drugs.

1982 • 14 citations

Sidechain-modified histamine analogues as substrates for histamine N-methyltransferase

1982 • 13 citations

Correlation between histamine-induced neuronal excitability and activation of adenylate cyclase in the guinea pig hippocampus

1984 • 7 citations