Multihormonal Regulation of the Human, Rat, and Bovine Growth Hormone Promoters: Differential Effects of 3′,5′-Cyclic Adenosine Monophosphate, Thyroid Hormone, and Glucocorticoids

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

Human growth hormone as a reporter gene in regulation studies employing transient gene expression.

1986 • 667 citations

Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.

1986 • 427 citations

A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone

1987 • 347 citations

Glucocorticoid and thyroid hormones transcriptionally regulate growth hormone gene expression.

1982 • 304 citations

A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells

1987 • 301 citations

Independent effects of growth hormone releasing factor on growth hormone release and gene transcription

1985 • 286 citations

Growth hormone gene transcription is regulated by thyroid and glucocorticoid hormones in cultured rat pituitary tumor cells.

1982 • 280 citations

Hormonal regulation of the growth hormone gene. Relationship of the rate of transcription to the level of nuclear thyroid hormone-receptor complexes.

1984 • 259 citations

Glucocorticoids enhance stability of human growth hormone mRNA.

1987 • 250 citations

Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene.

1985 • 235 citations

Thyroid or glucocorticoid hormone induces pre-growth-hormone mRNA and its probable nuclear precursor in rat pituitary cells.

1981 • 232 citations

Regulated expression of human growth hormone genes in mouse cells

1982 • 219 citations

Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.

1987 • 218 citations

Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expression.

1987 • 216 citations

The first intron of the human growth hormone gene contains a binding site for glucocorticoid receptor.

1985 • 215 citations

Cloning and nucleotide sequencing of the bovine growth hormone gene

1982 • 214 citations

CAT vectors for analysis of eukaryotic promoters and enhancers

1986 • 184 citations

Rapid Effects of Single Small Doses of L-Thyroxine and Triiodo-L-thyronine on Growth Hormone, as Studied in the Rat by Radioimmunoassay¹

1975 • 177 citations

Regulation of growth hormone messenger RNA synthesis by dexamethasone and triiodothyronine

1985 • 173 citations

cis-acting elements of the rat growth hormone gene which mediate basal and regulated expression by thyroid hormone.

1987 • 159 citations

Cyclic AMP Regulation of Eukaryotic Gene Transcription by Two Discrete Molecular Mechanisms

1985 • 103 citations

In vitro activation of the HIV-1 enhancer in extracts from cells treated with a phorbol ester tumor promoter.

1987 • 100 citations

Repression mediates cell-type-specific expression of the rat growth hormone gene.

1986 • 99 citations

Thyroid hormone regulation of the transfected rat growth hormone promoter.

1986 • 97 citations

5'-Flanking DNA of the rat growth hormone gene mediates regulated expression by thyroid hormone.

1985 • 91 citations

Growth and Growth Hormone. III. Growth Hormone Release in Children with Primary Hypothyroidism and Thyrotoxicosis¹

1969 • 90 citations

Introduction of rat growth hormone gene into mouse fibroblasts via a retroviral DNA vector: expression and regulation.

1982 • 88 citations

Sequences required for cell-type specific thyroid hormone regulation of rat growth hormone promoter activity.

1986 • 86 citations

The human growth hormone gene is negatively regulated by triiodothyronine when transfected into rat pituitary tumor cells.

1986 • 82 citations

Blunted Growth Hormone (GH) Response to GH-Releasing Hormone in Hypothyroidism Resolves in the Euthyroid State*

1985 • 71 citations

Transient Neonatal Hyperthyrotropinemia: A Factitious Syndrome due to the Presence of Heterophilic Antibodies in the Plasma of Infants and Their Mothers*

1981 • 62 citations

Discrete positive and negative thyroid hormone-responsive transcription regulatory elements of the rat growth hormone gene.

1987 • 61 citations

Increase in Plasma Growth Hormone Levels Following Thyrotropin-Releasing Hormone Injection in Children with Primary Hypothyroidism

1977 • 61 citations

Insulin-Like Growth Factor I Action on Rat Anterior Pituitary Cells: Effects of Intracellular Messengers on Growth Hormone Secretion and Messenger Ribonucleic Acid Levels*

1987 • 57 citations

Regulated expression of chimaeric genes containing the 5′-flanking regions of human growth hormone-related genes in transiently transfected rat anterior pituitary tumor cells

1987 • 55 citations

Relationship between the Accumulation of Pituitary Growth Hormone and Nuclear Occupancy by Triiodothyronine in the Rat

1978 • 54 citations

Thyroid hormone receptors bind to defined regions of the growth hormone and placental lactogen genes.

1986 • 51 citations

Hormonal Regulation of Expression of the Endogenous and Transfected Human Growth Hormone Gene

1987 • 36 citations

GROWTH HORMONE RESPONSES TO GRF 1–29 IN PATIENTS WITH PRIMARY HYPOTHYROIDISM BEFORE AND DURING REPLACEMENT THERAPY WITH THYROXINE

1986 • 28 citations