Radioimmunoassay and competitive binding radioassay methods for the measurement of drugs

IMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MAN

1960 • 2,983 citations

The Pharmacological Basis of Therapeutics

1971 • 1,765 citations

Assay of Plasma Insulin in Human Subjects by Immunological Methods

1959 • 1,077 citations

Determination of Therapeutic and Toxic Serum Digoxin Concentrations by Radioimmunoassay

1969 • 599 citations

IMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MAN

1996 • 444 citations

The doctor's mission.

1947 • 348 citations

Digoxin intoxication: the relationship of clinical presentation to serum digoxin concentration

1970 • 341 citations

Variation in Biologic Availability of Digoxin from Four Preparations

1971 • 292 citations

Serum Drug Concentrations as Therapeutic Guides

1972 • 265 citations

Immunologic Mechanisms of Penicillin Allergy

1966 • 265 citations

IV HOSPITALS IN THE UNITED STATES

1948 • 254 citations

Digoxin-specific antibodies.

1967 • 252 citations

Characterization of antibodies of high affinity and specificity for the digitalis glycoside digoxin

1970 • 245 citations

The estimation of thyroxine in human plasma by an electrophoretic technique

1960 • 245 citations

The measurement of digitoxin in human serum by radioimmunoassay

1968 • 232 citations

Morphine: Radioimmunoassay

1970 • 211 citations

The Clinical Pharmacology of Digitalis Glycosides

1968 • 194 citations

Identification of Proinsulin and C-Peptide in Human Serum by a Specific Immunoassay

1970 • 164 citations

Application of the Property of Protein-Binding to the Assay of Minute Quantities of Hormones and Other Substances

1964 • 137 citations

Absorption of Digoxin in Patients with Malabsorption Syndromes

1971 • 125 citations

Ouabain Pharmacokinetics in Dog and Man

1972 • 121 citations

Quantitative determination of morphine in serum by radioimmunoassay.

1971 • 116 citations

Measurement of Medroxyprogesterone Acetate (Provera) by Radioimmunoassay¹

1971 • 112 citations

VARIATION IN THE BIOLOGICAL AVAILABILITY OF DIGOXIN

1972 • 103 citations

Plasma Concentrations of Digoxin after Oral Administration in the Fasting and Postprandial State

1971 • 101 citations

Absorption of orally given digoxin preparations.

1972 • 97 citations

Radioisotopic Assay for Measurement of Serum Folate Levels

1971 • 97 citations

Myocardial and Skeletal Muscle Concentrations of Digoxin in Patients on Long-term Therapy

1972 • 87 citations

Radioimmunoassay for serum digitoxin concentration: methodology and clinical experience.

1970 • 82 citations

Detection of Morphine by Hemagglutination-Inhibition

1971 • 79 citations

Isotopic Tracers in the Study of Diabetes

1959 • 79 citations

A Fraction of the Ventricular Myocardium That Has the Specificity of the Cardiac Beta-Adrenergic Receptor

1971 • 78 citations

Radioimmunoassay of an Antibiotic: Gentamicin

1972 • 74 citations

Serum Cardiac Glycoside Assay Based upon Displacement of ³ H-Ouabain from Na-K ATPase

1972 • 71 citations

Ouabain-specific antibodies: immunochemical properties and reversal of Na+, K+-activated adenosine triphosphatase inhibition

1972 • 65 citations

Antigenicity of Steroid-Protein Conjugates

1959 • 64 citations

Specificities of antibodies to morphine.

1972 • 62 citations

Assays of digitalis in the blood

1972 • 62 citations

Antibodies to Small Molecules: Biological and Clinical Applications

1973 • 57 citations

Contribution of Quantitative Assay Technics to the Understanding of the Clinical Pharmacology of Digitalis

1972 • 56 citations

Utility of Clinical Chemical Determinations of Drug Concentrations in Biological Fluids

1971 • 54 citations

Hapten-radioimmunoassay: A general procedure for the estimation of steroidal and other haptenic substances

1969 • 49 citations

Radioimmunoassay of bradykinin: chemical modification to enable use of radioactive iodine.

1969 • 49 citations

Assay of Serum Vitamin B12 Concentration Using Co57-B12 and Intrinsic Factor

1961 • 48 citations

Radioimmunoassays of Peptide Hormones in Plasma

1967 • 43 citations

Antibodies to Two Common Pesticides, DDT and Malathion

1970 • 43 citations

A radioimmunoassay for diphenylhydantoin

1973 • 42 citations

Barbiturates: Radioimmunoassay

1971 • 41 citations

Digoxin: Immunologic Approaches to Measurement and Reversal of Toxicity

1970 • 39 citations

Studies on the induction of antibody synthesis against sulfanilic acid in rabbits. 1. Effect of the number of hapten molecules introduced in homologous protein on antibody synthesis against the hapten and the new antigenic determinants

1972 • 39 citations

BIOAVAILABILITY OF DIGOXIN

1973 • 37 citations

Chloramphenicol-Specific Antibody

1966 • 37 citations

Determination of barbiturate derivatives by radioimmunoassay.

1972 • 37 citations

Radioimmunoassay of prostaglandins, angiotensin, digoxin, morphine and adenosine-3′, 5′-cyclic-monophosphate with nitrocellulose membranes

1972 • 37 citations

Studies in synthetic immuno-chemistry

1940 • 33 citations

Natural antibodies to procaine amide.

1968 • 30 citations

Specificity of the Antibody Receptor Site to D-Lysergamide: Model of a Physiological Receptor for Lysergic Acid Diethylamide

1971 • 30 citations

Peptide hormones in plasma.

1966 • 30 citations

The Detection of Humoral Antibodies Directed against Salicylates in Hypersensitive States

1963 • 30 citations

Antibodies to folic acid and methotrexate obtained with conjugates of synthetic polypeptides

1967 • 30 citations

Immunological Specificity of Sulfonamide Azoproteins

1942 • 29 citations

Production of Antibodies against Insecticide-Protein Conjugates

1968 • 27 citations

Production and specificity of antibodies directed toward 3,4,5-trimethoxyphenylethylamine, 3,4-dimethoxyphenylethylamine and 2,5-dimethoxy-4-methylamphetamine

1969 • 26 citations

BIOAVAILABILITY OF DIGOXIN

1972 • 22 citations

BIOAVAILABILITY OF DIGOXIN

1973 • 21 citations

Absorption of orally given digoxin preparations

1972 • 18 citations

BIOAVAILABILITY OF DIGOXIN

1972 • 17 citations

DIGOXIN RADIOIMMUNOASSAY

1971 • 16 citations

Hypersensitivity to aspirin: clinical and immunological studies.

1969 • 15 citations

Radioimmunoassay of peptides lacking tyrosine.

1970 • 14 citations

The effect of antibody to L-phenylalanine mustard conjugate on malignant cells selectively marked through "early inflammatory-like" vascular permeability.

1966 • 13 citations

Antigenicity of the tetracyclines

1965 • 10 citations

A SOURCE OF ERROR IN DIGOXIN RADIOIMMUNOASSAY

1970 • 10 citations

Antibodies to strychnine

1940 • 9 citations

Immunobiology: Current Knowledge of Basic Concepts in Immunology and Their Clinical Applications.

1972 • 8 citations

Radioimmunoassay: A Status Report

1968 • 8 citations

Demonstration of anti-hydralazine antibody in hydralazine inducedLupus erythematosus

1963 • 8 citations

In vitro recognition of diethylstilbestrol by anti-azobenzoyl estradiol IgG

1970 • 7 citations

Chloramphenicol-specific antibody. V. A method for the detection of anti-chloramphenicol antibody in human serum.

1971 • 4 citations

INTERFERENCE OF DIGITOXIN WITH THE RADIOIMMUNOASSAY OF DIGOXIN

1972 • 4 citations

Detection of glutethimide (doriden) by hemagglutination inhibition

1973 • 4 citations