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Adjuvant Treatment With a Mammalian Target of Rapamycin Inhibitor, Sirolimus, and Steroids Improves Outcomes in Patients With Severe H1N1 Pneumonia and Acute Respiratory Failure*

Data up to Jan 2025

Published2013
Citations133
References57
Clinical Trials (1)

Total Citations Per Year

Abstract

References (57)

APACHE II-A Severity of Disease Classification System

1986 • 12,607 citations

APACHE II

1985 • 12,347 citations

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

2007 • 4,077 citations

Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units

1998 • 3,133 citations

Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans

2009 • 2,995 citations

Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings

2009 • 1,918 citations

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

2002 • 1,717 citations

Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms

1998 • 1,516 citations

Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus

2007 • 933 citations

The interface between innate and adaptive immunity

2004 • 898 citations

Immunoregulatory functions of mTOR inhibition

2009 • 808 citations

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

2008 • 741 citations

Sirolimus: its discovery, biological properties, and mechanism of action

2003 • 717 citations

Methylprednisolone Infusion in Early Severe ARDS

2007 • 708 citations

Severe Respiratory Disease Concurrent with the Circulation of H1N1 Influenza

2009 • 697 citations

Hydrocortisone Infusion for Severe Community-acquired Pneumonia

2004 • 696 citations

Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in Ferrets

2009 • 605 citations

Influenza

1999 • 571 citations

Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

2006 • 555 citations

Lung Pathology in Fatal Novel Human Influenza A (H1N1) Infection

2009 • 534 citations

Manipulation of host-cell pathways by bacterial pathogens

2007 • 487 citations

A question of self‐preservation: immunopathology in influenza virus infection

2007 • 455 citations

Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

2008 • 375 citations

Critical Role of IL-17RA in Immunopathology of Influenza Infection

2009 • 342 citations

Early Corticosteroids in Severe Influenza A/H1N1 Pneumonia and Acute Respiratory Distress Syndrome

2011 • 316 citations

Immune Responses and Disease Enhancement during Respiratory Syncytial Virus Infection

2005 • 282 citations

The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications

2008 • 279 citations

Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection

2007 • 269 citations

The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway

2008 • 221 citations

The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival

2004 • 221 citations

Clinical aspects and cytokine response in severe H1N1 influenza A virus infection

2010 • 213 citations

The Multifunctional Role of mTOR in Innate Immunity: Implications for Transplant Immunity

2009 • 208 citations

Corticosteroid Treatment in Critically Ill Patients with Pandemic Influenza A/H1N1 2009 Infection

2011 • 208 citations

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells

2008 • 205 citations

NK T Cells Contribute to Expansion of CD8+T Cells and Amplification of Antiviral Immune Responses to Respiratory Syncytial Virus

2002 • 172 citations

Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagation

2007 • 159 citations

H1N1 influenza A virus-associated acute lung injury: response to combination oseltamivir and prolonged corticosteroid treatment

2009 • 152 citations

Antiviral CD8+ T cell effector activities in situ are regulated by target cell type

2010 • 133 citations

Differences in clinical outcomes after 2009 influenza A/H1N1 and seasonal influenza among hematopoietic cell transplant recipients

2011 • 132 citations

Regulatory T Cells Suppress CD8+ T Cell Responses Induced by Direct Priming and Cross-Priming and Moderate Immunodominance Disparities

2005 • 126 citations

Participation of Mammalian Target of Rapamycin Complex 1 in Toll-Like Receptor 2– and 4–Induced Neutrophil Activation and Acute Lung Injury

2009 • 113 citations

Immune dysregulation in severe influenza

2009 • 105 citations

Prolonged viral shedding in pandemic influenza A(H1N1): clinical significance and viral load analysis in hospitalized patients

2010 • 85 citations

Maintenance immunosuppressive therapy with everolimus preserves humoral immune responses

2010 • 69 citations

Altered Pathogenesis of Porcine Respiratory Coronavirus in Pigs due to Immunosuppressive Effects of Dexamethasone: Implications for Corticosteroid Use in Treatment of Severe Acute Respiratory Syndrome Coronavirus

2007 • 62 citations

Inhibition of Influenza a Virus Replication by Antagonism of a PI3K-AKT-mTOR Pathway Member Identified by Gene-Trap Insertional Mutagenesis

2012 • 60 citations

INFLUENZA

2000 • 59 citations

Distinctly different expression of cytokines and chemokines in the lungs of two H5N1 avian influenza patients

2008 • 59 citations

IFN-γ production downstream of NKT cell activation in mice infected with influenza virus enhances the cytolytic activities of both NK cells and viral antigen-specific CD8+ T cells

2010 • 58 citations

Rapamycin suppresses TLR4-triggered IL-6 and PGE2 production of colon cancer cells by inhibiting TLR4 expression and NF-κB activation

2008 • 52 citations

The Battle over mTOR: An Emerging Theatre in Host–Pathogen Immunity

2012 • 50 citations

Therapy With m-TOR Inhibitors Decreases the Response to the Pandemic Influenza A H1N1 Vaccine in Solid Organ Transplant Recipients

2011 • 49 citations

Systemic Corticosteroids and Early Administration of Antiviral Agents for Pneumonia with Acute Wheezing due to Influenza A(H1N1)pdm09 in Japan

2012 • 46 citations

Rapamune (RAPA, rapamycin, sirolimus): Mechanism of Action Immunosuppressive Effect Results From Blockade of Signal Transduction and Inhibition of Cell Cycle Progression

2006 • 45 citations

Oseltamivir, an Influenza Neuraminidase Inhibitor Drug, Does Not Affect the Steady-State Pharmacokinetic Characteristics of Cyclosporine, Mycophenolate, or Tacrolimus in Adult Renal Transplant Patients

2011 • 13 citations

Involvement of c-Jun NH2 Terminal Kinase and p38MAPK in Rapamycin-Mediated Inhibition of Neointimal Formation in Rat Carotid Arteries

2005 • 13 citations

Involvement of type I immune responses in swine-origin H1N1 influenza virus infection

2011 • 12 citations

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Adjuvant Treatment With a Mammalian Target of Rapamycin Inhibitor, Sirolimus, and… (2013) – Critical Care Medicine | Metascience Observatory Explorer