Soluble intercellular adhesion molecule-1 provokes polymorphonuclear leukocyte elastase release by CD18

Adhesion receptors of the immune system

1990 • 6,585 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells.

1990 • 799 citations

A form of circulating ICAM-1 in human serum.

1991 • 700 citations

Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells

1992 • 653 citations

ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells

1988 • 580 citations

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.

1986 • 576 citations

E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro.

1992 • 519 citations

A monoclonal antibody to the adherence-promoting leukocyte glycoprotein, CD18, reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits.

1988 • 434 citations

Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin.

1993 • 187 citations

Inhibition of CD18-dependent neutrophil adherence reduces organ injury after hemorrhagic shock in primates.

1990 • 158 citations

Circulating ICAM-1 is increased in septic shock.

1995 • 135 citations

Compartmentalized roles for leukocytic adhesion molecules in lung inflammatory injury.

1995 • 115 citations

Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome.

1985 • 112 citations

Cross-linking of CD18 in human neutrophils induces an increase of intracellular free Ca2+, exocytosis of azurophilic granules, quantitative up-regulation of CD18, shedding of L-selectin, and actin polymerization

1994 • 95 citations

ELEVATED LEVELS OF SOLUBLE ICAM-1 CORRELATE WITH THE DEVELOPMENT OF MULTIPLE ORGAN FAILURE IN SEVERELY INJURED TRAUMA PATIENTS

1994 • 81 citations

The Role of Phagocyte Proteinases and Proteinase Inhibitors in Multiple Organ Failure

1994 • 72 citations

Neutrophil CD18 Expression and Blockade After Traumatic Shock and Endotoxin Challenge

1994 • 47 citations

Inhibition of Leukocyte Adherence and Susceptibility to Infection

1993 • 34 citations

Soluble ICAM-1 (sICAM-1) Provokes PMN Elastase Release

1996 • 20 citations

Intercellular adhesion molecule—1 promotes neutrophil-mediated cytotoxicity*

1995 • 19 citations

Functional studies of stable L cell transfectants expressing intercellular adhesion molecule 1 [ICAM‐1]

1989 • 4 citations