Quantitative analysis of drug-receptor interactions: II. Determination of the properties of receptor subtypes

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

A STUDY OF THE ADRENOTROPIC RECEPTORS

1948 • 2,856 citations

Definition and Antagonism of Histamine H2-receptors

1972 • 2,284 citations

Differentiation of Receptor Systems activated by Sympathomimetic Amines

1967 • 2,054 citations

Presynaptic regulation of catecholamine release

1974 • 1,145 citations

A functional basis for classification of α-adrenergic receptors

1977 • 802 citations

On the Evaluation of the Constants V _m and K _M in Enzyme Reactions

1952 • 746 citations

Quantitative analysis of drug-receptor interactions: I. Determination of kinetic and equilibrium properties

1981 • 557 citations

Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha noradrenergic receptors.

1977 • 544 citations

Differentiation of receptors responsive to isoproterenol

1967 • 484 citations

Simultaneous determination of beta-1 and beta-2-adrenergic receptors in tissues containing both receptor subtypes.

1979 • 418 citations

Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides.

1979 • 399 citations

beta-Adrenergic Receptor Subtypes: Properties, Distribution, and Regulation

1981 • 277 citations

Differentiation of cardiac chronotropic and inotropic effects of ?-adrenoceptor agonists

1977 • 260 citations

The mobile receptor hypothesis and “cooperativity” of hormone binding. Application to insulin

1976 • 258 citations

Differentiated blockade of the chronotropic effects of various adrenergic stimuli in the cat heart

1972 • 246 citations

Comparison of beta adrenergic receptor subtypes in mammalian tissues.

1979 • 245 citations

Multiple Neurotransmitter Receptors

1980 • 223 citations

On the Evaluation of the Constants Vm and KM in Enzyme Reactions

1952 • 150 citations

Multiple classes of dopamine receptors in mammalian central nervous system: The involvement of dopamine-sensitive adenylyl cyclase

1978 • 149 citations

Classification and quantitation of β-adrenergic receptor subtypes

1980 • 122 citations

The non-stoichiometric floating receptor model for hormone sensitive adenylyl cyclase

1976 • 106 citations

Binding of hormones to receptors. Alternative explanation of nonlinear Scatchard plots

1975 • 85 citations

Multiple effects of guanosine triphosphate on beta adrenergic receptors and adenylate cyclase activity in rat heart, lung and brain.

1979 • 64 citations

The two-step model of ligand-receptor interaction

1977 • 63 citations

THE CONTRIBUTION OF EXTRANEURONAL UPTAKE TO THE TRACHEA‐BLOOD VESSEL SELECTIVITY OF β‐ADRENOCEPTOR STIMULANTS in vitro IN GUINEA‐PIGS

1976 • 45 citations