Cloning and expression of genes for the Oxytricha telomere-binding protein: Specific subunit interactions in the telomeric complex

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Calculation of protein extinction coefficients from amino acid sequence data

1989 • 5,198 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Structure and function of telomeres

1991 • 3,524 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

1941 • 1,586 citations

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1989 • 1,509 citations

Monovalent cation-induced structure of telomeric DNA: The G-quartet model

1989 • 1,202 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops

1989 • 939 citations

Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine·guanine base pairs

1987 • 675 citations

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

1990 • 632 citations

STRUCTURE AND FUNCTION OF TELOMERES

1989 • 604 citations

Improved detection of helix-turn-helix DNA-binding motifs in protein sequences

1990 • 526 citations

Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae.

1988 • 511 citations

All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus.

1981 • 477 citations

Three-dimensional architecture of a polytene nucleus

1983 • 453 citations

RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability

1990 • 436 citations

The remaking of chromosomes

1938 • 416 citations

Functional Evidence for an RNA Template in Telomerase

1990 • 392 citations

Involvement of the Silencer and UAS Binding Protein RAP1 in Regulation of Telomere Length

1990 • 326 citations

The Fusion of Broken Ends of Chromosomes Following Nuclear Fusion

1942 • 321 citations

Telomere proteins: Specific recognition and protection of the natural termini of Oxytricha macronuclear DNA

1986 • 305 citations

An overhanging 3' terminus is a conserved feature of telomeres.

1989 • 286 citations

Rapid and Efficient Site-Specific Mutagenesis without Phenotypic Selection

1989 • 233 citations

Telomere terminal transferase activity in the hypotrichous ciliateOxytricha novaand a model for replication of the ends of linear DNA molecules

1988 • 171 citations

Telomeric DNA-protein interactions of Oxytricha macronuclear DNA.

1987 • 152 citations

Dramatic events in ciliate evolution: alteration of UAA and UAG termination codons to glutamine codons due to anticodon mutations in two Tetrahymena tRNAs^Gln

1986 • 151 citations

Chromatin structure of the molecular ends of oxytricha macronuclear DNA: phased nucleosomes and a telomeric complex

1984 • 139 citations

A U-rich tract enhances usage of an alternative 3′ splice site in yeast

1991 • 119 citations

Effect of monovalent cation-induced telomeric DNA structure on the binding of Oxytricha telomeric protein

1990 • 113 citations

Gene-sized DNA molecules of the macronuclei in three species of hypotrichs: Size distributions and absence of nicks

1980 • 111 citations

An intervening sequence in an unusual histone H1 gene of Tetrahymena thermophila.

1986 • 108 citations

Properties of the telomeric DNA-binding protein from Oxytricha nova

1989 • 96 citations

Alternative processing during development of a macronuclear chromosome family in Oxytricha fallax.

1987 • 82 citations

A yeast protein that binds to vertebrate telomeres and conserved yeast telomeric junctions.

1991 • 80 citations

Production and characterization of human basic fibroblast growth factor from Escherichia coli.

1988 • 76 citations

Reordering of nine exons is necessary to form a functional actin gene in Oxytricha nova.

1989 • 68 citations

Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova.

1990 • 66 citations

Assembly and self-association of Oxytricha telomeric nucleoprotein complexes

1989 • 58 citations

Telomere replication and fusion in eukaryotes

1979 • 57 citations

Oxytrichatelomeric nucleoprotein complexes reconstituted with synthetic DNA

1989 • 50 citations

Definition and identification of homology domains

1988 • 46 citations

An intron in a ribosomal protein gene from Tetrahymena

1986 • 41 citations

Characterization of a Telomere-Binding Protein from Physarum polycephalum

1991 • 38 citations

Characterization of a telomere-binding protein from Physarum polycephalum.

1991 • 21 citations