Local administration of morphine decreases the extracellular level of GABA in the periaqueductal gray matter of freely moving rats

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

Microdialysis—principles and applications for studies in animals and man

1991 • 811 citations

Narcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques

1977 • 656 citations

The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: Further studies on the anatomy of pain modulation

1979 • 629 citations

Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray

1976 • 598 citations

Evidence that an excitatory connection between the periaqueductal gray and nucleus raphe magnus mediates stimulation produced analgesia

1979 • 433 citations

Electrophysiology of opioids.

1983 • 377 citations

Evidence for GABA involvement in midbrain control of medullary neurons that modulate nociceptive transmission

1986 • 281 citations

Determination of morphine, morphine-3-glucuronide and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography

1982 • 278 citations

On the central sites for the antinociceptive action of morphine and fentanyl

1970 • 265 citations

GABAergic modulation of the analgesic effects of morphine microinjected in the ventral periaqueductal gray matter of the rat

1987 • 156 citations

The effect of GABA and its antagonists on midbrain periaqueductal gray neurons in the rat

1990 • 124 citations

Inhibition by opioids acting on μ‐receptors of GABAergic and glutamatergic postsynaptic potentials in single rat periaqueductal gray neurones in vitro

1994 • 105 citations

Systemic morphine reduces GABA release in the lateral but not the medial portion of the midbrain periaqueductal gray of the rat

1992 • 82 citations

Periaqueductal grey lesions reduce morphine analgesia in the rat

1977 • 78 citations

Analysis of Human Cerebrospinal Fluid by Capillary Electrophoresis with Laser-Induced Fluorescence Detection

1994 • 77 citations

Collateralization of periaqueductal gray neurons to forebrain or diencephalon and to the medullary nucleus raphe magnus in the rat

1991 • 57 citations

Individualisation d'un sommeil à ondes lentes et activité phasique

1967 • 51 citations

Different mechanisms mediate beta-endorphin- and morphine-induced inhibition of the tail-flick response in rats.

1990 • 47 citations

Capillary electrophoresis with laser-induced fluorescence detection: a sensitive method for monitoring extracellular concentrations of amino acids in the periaqueductal grey matter

1996 • 47 citations

Ultrastructural morphometric analysis of GABA-immunoreactive terminals in the ventrocaudal periaqueductal grey: analysis of the relationship of GABA terminals and the GABAA receptor to periaqueductal grey-raphe magnus projection neurons

1990 • 47 citations