Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity

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European-Canadian randomized trial of paclitaxel in relapsed ovarian cancer: high-dose versus low-dose and long versus short infusion.

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Taxol Suppresses Dynamics of Individual Microtubules in Living Human Tumor Cells

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Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid

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Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.

1994 • 390 citations

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

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Peripheral neuropathy from taxol and cisplatin combination chemotherapy: Clinical and electrophysiological studies

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Taxol produces a predominantly sensory neuropathy

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Pharmacogenetic Assessment of Toxicity and Outcome After Platinum Plus Taxane Chemotherapy in Ovarian Cancer: The Scottish Randomised Trial in Ovarian Cancer

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Japanese-US Common-Arm Analysis of Paclitaxel Plus Carboplatin in Advanced Non–Small-Cell Lung Cancer: A Model for Assessing Population-Related Pharmacogenomics

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Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 Polymorphisms with the Pharmacokinetics of Paclitaxel

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Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide

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Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia

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Variants in the SLCO1B3 Gene: Interethnic Distribution and Association with Paclitaxel Pharmacokinetics

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Non-synonymous Single Nucleotide Alterations Found in the CYP2C8 Gene Result in Reduced in Vitro Paclitaxel Metabolism.

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Taxol impairs anterograde axonal transport of microinjected horseradish peroxidase in dorsal root ganglia neurons in vitro

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Taxol impairs anterograde axonal transport of microinjected horseradish peroxidase in dorsal root ganglia neurons in vitro

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DIFFERENT IN VITRO METABOLISM OF PACLITAXEL AND DOCETAXEL IN HUMANS, RATS, PIGS, AND MINIPIGS

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Ethnicity-Related Polymorphisms and Haplotypes in the Human ABCB1 Gene

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Is advanced age associated with increased incidence and severity of chemotherapy-induced peripheral neuropathy?

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Modification of paclitaxel metabolism in a cancer patient by induction of cytochrome P450 3A4.

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Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism

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Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease

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Morphological evidence of the inhibitory effect of taxol on the fast axonal transport

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High-dose paclitaxel in combination with doxorubicin, cyclophosphamide and peripheral blood progenitor cell rescue in patients with high-risk primary and responding metastatic breast carcinoma: toxicity profile, relationship to paclitaxel pharmacokinetics and short-term outcome

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2001 • 38 citations

Comparative neurotoxicity of weekly non-break paclitaxel infusions over 1 versus 3 h

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Impact of Genetic Polymorphisms in CYP2C8 and Rosiglitazone Intake on the Urinary Excretion of Dihydroxyeicosatrienoic Acids

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