Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms' tumour

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

Genomic imprinting: parental influence on the genome

2001 • 2,253 citations

Tumour-suppressor activity of H19 RNA

1993 • 638 citations

Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12

2003 • 460 citations

A Pituitary-Derived MEG3 Isoform Functions as a Growth Suppressor in Tumor Cells

2003 • 422 citations

Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q

2000 • 360 citations

The Dlk1 and Gtl2 genes are linked and reciprocally imprinted

2000 • 304 citations

Beckwith-Wiedemann syndrome: imprinting in clusters revisited

2000 • 299 citations

Beckwith-Wiedemann syndrome demonstrates a role for epigenetic control of normal development

2003 • 288 citations

Novel Imprinted DLK1/GTL2 Domain on Human Chromosome 14 Contains Motifs that Mimic Those Implicated in IGF2/H19 Regulation

2000 • 272 citations

Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19 -associated CTCF-binding sites in colorectal cancer

2000 • 228 citations

DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms

2002 • 226 citations

Identification of the Single Base Change Causing the Callipyge Muscle Hypertrophy Phenotype, the Only Known Example of Polar Overdominance in Mammals

2002 • 224 citations

Delta-like and Gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12

2000 • 220 citations

Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: implications for imprinting control from comparison with Igf2-H19

2002 • 219 citations

Insights from gene arrays on the development and growth regulation of uterine leiomyomata

2002 • 189 citations

Epigenetic gene silencing in cancer

2000 • 179 citations

The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status

2001 • 168 citations

Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12

2000 • 166 citations

Identification of myelodysplastic syndrome–specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction

2001 • 163 citations

The callipyge locus: evidence for the trans interaction of reciprocally imprinted genes

2003 • 143 citations

Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site.

2001 • 138 citations

Comparative Sequence Analysis of the Imprinted Dlk1–Gtl2 Locus in Three Mammalian Species Reveals Highly Conserved Genomic Elements and Refines Comparison with the Igf2–H19 Region

2001 • 123 citations

Mouse Peg9/Dlk1 and human PEG9/DLK1 are paternally expressed imprinted genes closely located to the maternally expressed imprinted genes: mouse Meg3/Gtl2 and human MEG3

2000 • 115 citations

Identification of interstitial maternal uniparental disomy (UPD) (14) and complete maternal UPD(20) in a cohort of growth retarded patients

2001 • 75 citations

High delta‐like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type

2003 • 71 citations

Epigenetic detection of human chromosome 14 uniparental disomy

2003 • 69 citations

Paternal UPD14 is responsible for a distinctive malformation complex

2002 • 66 citations

dlk Modulates Mitogen-Activated Protein Kinase Signaling to Allow or Prevent Differentiation

2002 • 55 citations

SAGE analysis of neuroblastoma reveals a high expression of the human homologue of theDrosophila Delta gene

2000 • 47 citations

Imprinting status of DLK1 gene in brain tumors and lymphomas

2004 • 12 citations