The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

A general method ofin vitropreparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

1988 • 2,410 citations

Regulating the fate of mRNA: The control of cellular iron metabolism

1993 • 1,233 citations

Transition Metals in Control of Gene Expression

1993 • 629 citations

Superoxide sensitivity of the Escherichia coli aconitase.

1991 • 499 citations

Sequence-Specific Binding of Transfer RNA by Glyceraldehyde-3-Phosphate Dehydrogenase

1993 • 461 citations

Evidence that luminal ER proteins are sorted from secreted proteins in a post-ER compartment.

1988 • 434 citations

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.

1993 • 409 citations

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.

1993 • 393 citations

Oxidation-Reduction and the Molecular Mechanism of a Regulatory RNA-Protein Interaction

1989 • 387 citations

Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein.

1992 • 345 citations

Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding.

1992 • 324 citations

Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster.

1992 • 272 citations

RNA recognition by an isolated α helix

1993 • 265 citations

Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal.

1989 • 245 citations

Crystal structures of aconitase with isocitrate and nitroisocitrate bound

1992 • 214 citations

Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells.

1993 • 210 citations

Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.

1990 • 205 citations

A regulated RNA binding protein also possesses aconitase activity.

1991 • 204 citations

Role of RNA structure in arginine recognition of TAR RNA.

1993 • 191 citations

Three small ribooligonucleotides with specific arginine sites

1993 • 183 citations

The structure of aconitase

1989 • 183 citations

Mutational analysis of the [4Fe-4S]-cluster converting iron regulatory factor from its RNA-binding form to cytoplasmic aconitase.

1994 • 176 citations

Regulation of Interaction of the Iron-Responsive Element Binding Protein with Iron-Responsive RNA Elements

1989 • 164 citations

The iron-responsive element-binding protein: localization of the RNA-binding site to the aconitase active-site cleft.

1994 • 122 citations

A double life: cytosolic aconitase as a regulatory RNA binding protein.

1993 • 108 citations

The activation of aconitase by ferrous ions and reducing agents

1954 • 107 citations

The putative iron-responsive element in the human erythroid 5-aminolevulinate synthase mRNA mediates translational control

1993 • 103 citations

Modification of a free Fe-S cluster cysteine residue in the active iron-responsive element-binding protein prevents RNA binding.

1993 • 103 citations

A tyrosyl-tRNA synthetase binds specifically to the group I intron catalytic core.

1992 • 97 citations

Iron regulatory factor expressed from recombinant baculovirus: conversion between the RNA-binding apoprotein and Fe-S cluster containing aconitase

1993 • 93 citations

Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor.

1988 • 91 citations

A steroid-inducible promoter for the controlled overexpression of cloned genes in eukaryotic cells.

1993 • 90 citations

Mutational analysis of active site residues in pig heart aconitase.

1992 • 57 citations

Metabolic Studies on Citrate Synthase Mutants of Yeast

1989 • 56 citations

Overexpression of Iron-Responsive Element-Binding Protein and Its Analytical Characterization as the RNA-Binding Form, Devoid of an Iron-Sulfur Cluster

1994 • 42 citations

Social Medicine: Drug Abuse in Business

1970 • 1 citations