Back to search

Disruption of the Type III Adenylyl Cyclase Gene Leads to Peripheral and Behavioral Anosmia in Transgenic Mice

Data up to Jan 2025

Published2000
Citations460
References73

Total Citations Per Year

Abstract

References (73)

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

A novel multigene family may encode odorant receptors: A molecular basis for odor recognition

1991 • 4,793 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits

1991 • 1,076 citations

G olf : an Olfactory Neuron Specific-G Protein Involved in Odorant Signal Transduction

1989 • 863 citations

Complexity and Diversity of Mammalian Adenylyl Cyclases

1996 • 857 citations

Identification of a Specialized Adenylyl Cyclase That May Mediate Odorant Detection

1990 • 695 citations

Odorant-sensitive adenylate cyclase may mediate olfactory reception

1985 • 583 citations

Mice Deficient in Golf Are Anosmic

1998 • 563 citations

General Anosmia Caused by a Targeted Disruption of the Mouse Olfactory Cyclic Nucleotide–Gated Cation Channel

1996 • 508 citations

Transduction Mechanisms in Vertebrate Olfactory Receptor Cells

1998 • 493 citations

Calcium-Stimulated Adenylyl Cyclase Activity Is Critical for Hippocampus-Dependent Long-Term Memory and Late Phase LTP

1999 • 482 citations

Rapid kinetics of second messenger formation in olfactory transduction

1990 • 438 citations

The odorant-sensitive adenylate cyclase of olfactory receptor cells. Differential stimulation by distinct classes of odorants.

1986 • 433 citations

GATA-3 Is Involved in the Development of Serotonergic Neurons in the Caudal Raphe Nuclei

1999 • 411 citations

Analysis of the electrical activity of the olfactory epithelium.

1955 • 391 citations

Expression of members of the putative olfactory receptor gene family in mammalian germ cells

1992 • 391 citations

Vertebrate Olfactory Reception

1986 • 386 citations

Bound and determined: A computer program for making buffers of defined ion concentrations

1992 • 335 citations

Behavioural assessment of mice lacking D1A dopamine receptors

1998 • 325 citations

Protein determination using bicinchoninic acid in the presence of sulfhydryl reagents

1988 • 311 citations

Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants.

1990 • 292 citations

Calcium-activated chloride conductance in frog olfactory cilia

1991 • 288 citations

Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain.

1991 • 286 citations

Effects of discrete kainic acid-induced hippocampal lesions on spatial and contextual learning and memory in rats

1996 • 213 citations

Properties of cyclic nucleotide-gated channels mediating olfactory transduction. Activation, selectivity, and blockage.

1992 • 193 citations

Odor-Induced Membrane Currents in Vertebrate-Olfactory Receptor Neurons

1989 • 191 citations

Cyclic Nucleotide-Gated Ion Channels and Sensory Transduction in Olfactory Receptor Neurons

1994 • 190 citations

Phosphorylation and Inhibition of Olfactory Adenylyl Cyclase by CaM Kinase II in Neurons

1998 • 184 citations

Denervation of the primary olfactory pathway in mice. V. Long-term effect of intranasal ZnSO4 irrigation on behavior, biochemistry and morphology

1978 • 162 citations

Phosphorylation and Inhibition of Type III Adenylyl Cyclase by Calmodulin-dependent Protein Kinase II in Vivo

1996 • 161 citations

Synergistic activation of the type I adenylyl cyclase by Ca2+ and Gs-coupled receptors in vivo.

1994 • 161 citations

Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs.

1996 • 157 citations

The spatial distributions of odorant sensitivity and odorant‐induced currents in salamander olfactory receptor cells.

1991 • 150 citations

Calmodulin-regulated adenylyl cyclases and neuromodulation

1997 • 138 citations

Adenylate cyclase mediates olfactory transduction for a wide variety of odorants.

1989 • 138 citations

Protein Kinase C Alters the Responsiveness of Adenylyl Cyclases to G Protein α and βγ Subunits

1996 • 138 citations

Ca2+ Inhibition of Type III Adenylyl Cyclase in Vivo

1995 • 138 citations

Odorants of the same odor class activate different second messenger pathways

1991 • 131 citations

Odorant‐ and Guanine Nucleotide‐Stimulated Phosphoinositide Turnover in Olfactory Ciliaa

1987 • 128 citations

Action potentials initiated by single channels opening in a small neuron (rat olfactory receptor)

1989 • 121 citations

Inhibition of the olfactory cyclic nucleotide gated ion channel by intracellular calcium

1991 • 121 citations

Phorbol ester stimulation of the type I and type III adenylyl cyclases in whole cells

1993 • 121 citations

A novel multigene family may encode odorant receptors.

1992 • 114 citations

Impaired Odor Adaptation in Olfactory Receptor Neurons after Inhibition of Ca2+/Calmodulin Kinase II

1999 • 99 citations

Signal transduction in olfactory neurons

1991 • 88 citations

Differential Regulation of Type I and Type VIII Ca2+-stimulated Adenylyl Cyclases by Gi-coupled Receptors in Vivo

1996 • 86 citations

Olfactory transduction: cross-talk between second-messenger systems

1990 • 83 citations

Chemosensation: molecular mechanisms in worms and mammals

1999 • 79 citations

Olfactory adenylate cyclase of the rat Stimulation by odorants and inhibition by Ca2+

1986 • 78 citations

Genes encoding components of the olfactory signal transduction cascade contain a DNA binding site that may direct neuronal expression.

1993 • 76 citations

Secretion and electrogenesis of the supporting cell in the olfactory epithelium

1974 • 74 citations

Olfactory adenylyl cyclase

1989 • 72 citations

The olfactory adenylyl cyclase type 3 is expressed in male germ cells

1998 • 71 citations

Spatial Distribution of the EOG in the Rat; a Variation with Odour Quality

1977 • 63 citations

The Olfactory Adenylyl Cyclase III Is Expressed in Rat Germ Cells during Spermiogenesis*

1998 • 55 citations

Olfactory marker protein: from PAGE band to cDNA clone

1985 • 54 citations

Signal integration in the nervous system: adenylate cyclases as molecular coincidence detectors

1994 • 53 citations

Regulation and Immunohistochemical Localization of βγ-Stimulated Adenylyl Cyclases in Mouse Hippocampus

1999 • 46 citations

Synaptic Transmission and Hippocampal Long-Term Potentiation in Olfactory Cyclic Nucleotide-Gated Channel Type 1 Null Mouse

1998 • 44 citations

Current recording from sensory cilia of olfactory receptor cells in situ. II. Role of mucosal Na+, K+, and Ca2+ ions.

1991 • 37 citations

Decreased renal Na-K-2Cl cotransporter abundance in mice with heterozygous disruption of the Gsα gene

1999 • 35 citations

Stimulation of Na+,K+,Cl- cotransport by forskolin-activated adenylyl cyclase in fetal human nonpigmented epithelial cells.

1994 • 25 citations

Role of alpha 1- and alpha 2-adrenergic receptors in Cl- transport across frog corneal epithelium

1988 • 25 citations

Calcium modulates circadian variation in cAMP-stimulated melatonin in chick pineal cells

1996 • 18 citations

Bound and Determined

1974 • 16 citations

The Effect of Litter Size on the Growth, Survival and Behaviour of Neonatal Bulbectomised Mice

1976 • 4 citations

Inhibitory effects of centrally and peripherally induced anosmia on mounting behavior in the female rat

1990 • 4 citations

Defer, N. et al. The olfactory adenylyl cyclase type 3 is expressed in male germ cells. FEBS Lett. 424, 216-220

1998 • 3 citations

Effects of Ca2+ and calmodulin on adenylyl cyclase activity in sheep olfactory epithelium

1995 • 1 citations

Cited By (0)

Loading...
Disruption of the Type III Adenylyl Cyclase Gene Leads to Peripheral and Behavioral… (2000) – Neuron | Metascience Observatory Explorer