Molecular Chaperones and the Centrosome

Principles that Govern the Folding of Protein Chains

1973 • 6,771 citations

MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS

1993 • 1,591 citations

The induction of gene activity in drosophila by heat shock

1979 • 1,308 citations

Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system.

1988 • 1,241 citations

Role of the Major Heat Shock Proteins as Molecular Chaperones

1993 • 1,096 citations

Microtubule assembly nucleated by isolated centrosomes

1984 • 775 citations

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

1994 • 651 citations

Pericentrin, a highly conserved centrosome protein involved in microtubule organization

1994 • 579 citations

A cytoplasmic chaperonin that catalyzes β-actin folding

1992 • 498 citations

In vitro reconstitution of centrosome assembly and function: The central role of γ-tubulin

1994 • 457 citations

TCP1 complex is a molecular chaperone in tubulin biogenesis

1992 • 457 citations

γ-Tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation

1992 • 447 citations

Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits.

1992 • 414 citations

Microtubule Organizing Centers

1985 • 412 citations

Characterization of the thermotolerant cell. I. Effects on protein synthesis activity and the regulation of heat-shock protein 70 expression.

1988 • 399 citations

Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptides

1980 • 395 citations

10-nm filaments are induced to collapse in living cells microinjected with monoclonal and polyclonal antibodies against tubulin.

1984 • 388 citations

A molecular chaperone from a thermophilic archaebacterium is related to the eukaryotic protein t-complex polypeptide-1

1991 • 340 citations

The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo.

1993 • 329 citations

Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material

1983 • 323 citations

T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol

1992 • 305 citations

Structural and chemical characterization of isolated centrosomes

1987 • 292 citations

Interactions of bacteriophage and host macromolecules in the growth of bacteriophage lambda

1984 • 246 citations

Examining the function and regulation of hsp 70 in cells subjected to metabolic stress

1992 • 236 citations

Characterization of the thermotolerant cell. II. Effects on the intracellular distribution of heat-shock protein 70, intermediate filaments, and small nuclear ribonucleoprotein complexes.

1988 • 195 citations

The yeast homolog to mouse Tcp-1 affects microtubule-mediated processes.

1991 • 175 citations

Chaperonin-mediated folding of vertebrate actin-related protein and gamma-tubulin

1993 • 174 citations

Molecular components of the centrosome

1993 • 164 citations

Molecular and Cellular Effects of Heat-shock and Related Treatments of Mammalian Tissue-culture Cells

1982 • 154 citations

The constitutive and stress inducible forms of hsp 70 exhibit functional similarities and interact with one another in an ATP-dependent fashion.

1993 • 148 citations

Inhibition of heat shock (stress) protein induction by deuterium oxide and glycerol: Additional support for the abnormal protein hypothesis of induction

1989 • 143 citations

Facilitated folding of actins and tubulins occurs via a nucleotide-dependent interaction between cytoplasmic chaperonin and distinctive folding intermediates.

1994 • 116 citations

Both viral (adenovirus E1B) and cellular (hsp 70, p53) components interact with centrosomes

1994 • 116 citations

A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle.

1994 • 113 citations

Heat shock alters centrosome organization leading to mitotic dysfunction and cell death

1993 • 92 citations

Five of the nine genetically defined regions of mousethaplotypes are involved in transmission ratio distortion

1987 • 89 citations

The t complex polypeptide 1 (TCP-1) is associated with the cytoplasmic aspect of Golgi membranes

1989 • 89 citations

Molecular Chaperones and the Centrosome

1996 • 76 citations

β-internexin is a microtubule-associated protein identical to the 70-kDa heat-shock cognate protein and the clathrin uncoating ATPase

1989 • 73 citations

The relationship of the rat brain 68 kDa microtubule-associated protein with synaptosomal plasma membranes and with the Drosophila 70 kDa heat-shock protein

1984 • 71 citations

The Mammalian Stress Response and the Cytoskeleton: Alterations in Intermediate Filaments^a

1985 • 67 citations

Primary structure and function of a second essential member of the heterooligomeric TCP1 chaperonin complex of yeast, TCP1 beta.

1994 • 60 citations

Centrosomes and the spatial distribution of microtubules in animal cells

1986 • 58 citations

Guidebook to the cytoskeletal and motor proteins

1994 • 57 citations

Synthesis of mouse t complex proteins during haploid stages of spermatogenesis

1987 • 54 citations

hsp70 is localized to the centrosome of dividing HeLa cells

1991 • 39 citations

The response of the centrosome to heat shock and related stresses in a Drosophila cell line

1990 • 36 citations

Thermotolerant cells possess an enhanced capacity to repair heat‐induced alterations to centrosome structure and function

1995 • 30 citations

The effect of the heat shock response on ultrastructure of the centrosome of Drosophila cultured cells in interphase: possible relation with changes in the chemical state of calcium.

1993 • 14 citations