Gradient-purged isotope filter experiments for the detection of bound water in proteins

Rapid recording of 2D NMR spectra without phase cycling. Application to the study of hydrogen exchange in proteins

1989 • 1,395 citations

Gradient-Tailored Water Suppression for 1H-15N HSQC Experiments Optimized to Retain Full Sensitivity

1993 • 1,113 citations

The importance of not saturating water in protein NMR. Application to sensitivity enhancement and NOE measurements

1993 • 891 citations

Protein Hydration in Aqueous Solution

1991 • 778 citations

Improved Sensitivity of HSQC Spectra of Exchanging Protons at Short Interscan Delays Using a New Fast HSQC (FHSQC) Detection Scheme That Avoids Water Saturation

1995 • 621 citations

Highly selective and π pulse generation

1984 • 511 citations

Radiation Damping in Magnetic Resonance Experiments

1954 • 502 citations

Studies of protein hydration in aqueous solution by direct NMR observation of individual protein-bound water molecules

1989 • 306 citations

Isotope-filtered 2D NMR of a protein-peptide complex: study of a skeletal muscle myosin light chain kinase fragment bound to calmodulin

1992 • 269 citations

Optimized recording of heteronuclear multidimensional NMR spectra using pulsed field gradients

1992 • 264 citations

NMR studies of water bound to biological molecules

1997 • 217 citations

Application of Phase-Modulated CLEAN Chemical EXchange Spectroscopy (CLEANEX-PM) to Detect Water−Protein Proton Exchange and Intermolecular NOEs

1997 • 150 citations

Measurement of amide proton exchange rates and NOEs with water in 13C/15N-enriched calcineurin B

1993 • 144 citations

Demagnetization field effects in two-dimensional solution NMR

1996 • 140 citations

Suppression of Radiation Damping in Multidimensional NMR Experiments Using Magnetic Field Gradients

1995 • 132 citations

Measurement of fast proton exchange rates in isotopically labeled compounds

1993 • 127 citations

An improved double-tuned and isotope-filtered pulse scheme based on a pulsed field gradient and a wide-band inversion shaped pulse

1996 • 108 citations

The nuclear magnetization as the origin of transient changes in the magnetic field in pulsed NMR experiments

1990 • 83 citations

An improved method for selectively observing protons attached to 12C in the presence of 1H13C spin pairs

1992 • 78 citations

Separation of intramolecular NOE and exchange peaks in water exchange spectroscopy using spin-echo filters

1996 • 70 citations

Three-quantum nuclear magnetic resonance spectroscopy of liquid water: Intermolecular multiple-quantum coherence generated by spin–cavity coupling

1990 • 64 citations

New NMR methods for the characterization of bound waters in macromolecules

1993 • 61 citations

The solution structure of serine protease PB92 from Bacillus alcalophilus presents a rigid fold with a flexible substrate-binding site

1997 • 57 citations

Solvent Magnetization Artifacts in High-Field NMR Studies of Macromolecular Hydration

1998 • 50 citations

Crystal structure of the high-alkaline serine protease PB92 from Bacillus alcalophilus

1992 • 47 citations

Elimination of cross-relaxation effects from two-dimensional chemical-exchange spectra of macromolecules

1990 • 44 citations

A 13C double-filtered NOESY with strongly reduced artefacts and improved sensitivity

1995 • 37 citations

Selective excitation of intense solvent signals in the presence of radiation damping

1995 • 36 citations

New pulsed field gradient NMR experiments for the detection of bound water in proteins

1995 • 33 citations

Strategies for eliminating unwanted cross-relaxation and coherence-transfer effects from two-dimensional chemical-exchange spectra

1991 • 28 citations

Diffusion Filters for Separation of Solvent−Protein and Protein−Protein Nuclear Overhauser Effects (HYDRA)

1996 • 26 citations

NMR Investigation of the Solution Conformation of Oxidized Flavodoxin from Desulfovibrio vulgaris

1996 • 25 citations

How to Reduce the Residual H2O Signal in the PFG DQ Experiments Recorded with OnlyzGradients

1997 • 6 citations

Removing Unwanted Signals from HSQC Spectra

1996 • 3 citations