Post-repolarization block of cloned sodium channels by saxitoxin: the contribution of pore-region amino acids

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Molecular Mechanisms of Local Anesthesia

1990 • 840 citations

Calcium channel characteristics conferred on the sodium channel by single mutations

1992 • 776 citations

Charge Movement Associated with the Opening and Closing of the Activation Gates of the Na Channels

1974 • 746 citations

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel

1992 • 708 citations

A transient calcium‐dependent chloride current in the immature Xenopus oocyte.

1983 • 627 citations

Primary structure and functional expression of a mammalian skeletal muscle sodium channel

1989 • 561 citations

A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties

1992 • 387 citations

A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II

1989 • 336 citations

Pursuing the structure and function of voltage-gated channels

1990 • 323 citations

Molecular Localization of an Ion-Binding Site Within the Pore of Mammalian Sodium Channels

1992 • 281 citations

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

1994 • 274 citations

Single sodium channels from rat brain incorporated into planar lipid bilayer membranes

1983 • 186 citations

Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating.

1981 • 184 citations

Voltage-dependent action of tetrodotoxin in mammalian cardiac muscle

1976 • 132 citations

Molecular basis for pharmacological differences between brain and cardiac sodium channels

1992 • 111 citations

Kinetic basis for insensitivity to tetrodotoxin and saxitoxin in sodium channels of canine heart and denervated rat skeletal muscle

1987 • 108 citations

Single-channel, macroscopic, and gating currents from sodium channels in the squid giant axon

1991 • 81 citations

Kinetic analysis of single sodium channels from canine cardiac Purkinje cells.

1990 • 81 citations

A voltage-dependent gating transition induces use-dependent block by tetrodotoxin o rat IIA sodium channels expressed in xenopus oocytes

1991 • 74 citations

Functional expression of the rat heart I Na⁺ channel isoform Demonstration of properties characteristic of native cardiac Na⁺ channels

1990 • 68 citations

Divalent cation competition with [3H]saxitoxin binding to tetrodotoxin-resistant and -sensitive sodium channels. A two-site structural model of ion/toxin interaction.

1993 • 60 citations

Voltage-dependent block by tetrodotoxin of the sodium channel in rabbit cardiac Purkinje fibers

1987 • 58 citations

The cloned cardiac Na channel ?-subunit expressed in Xenopus oocytes show gating and blocking properties of native channels

1992 • 49 citations

Use‐ and Voltage‐Dependent Block of the Sodium Channel by Saxitoxin

1986 • 49 citations

Gating currents associated with Na channels in canine cardiac Purkinje cells.

1990 • 43 citations

Use dependence of sodium current inhibition by tetrodotoxin in rat cardiac muscle: influence of channel state

1990 • 28 citations

All or none block of single Na+ channels by tetrodotoxin

1985 • 27 citations

Use-dependent block of sodium channels in frog myelinated nerve by tetrodotoxin and saxitoxin at negative holding potentials

1989 • 25 citations

Post-repolarization block of cardiac sodium channels by saxitoxin

1993 • 18 citations

Evidence for voltage-dependent block of cardiac sodium channels by tetrodotoxin

1988 • 18 citations

Voltage-dependent action of tetrodotoxin in mammalian cardiac myocytes

1986 • 12 citations

Use-dependent block with tetrodotoxin and saxitoxin at frog Ranvier nodes II. Extrinsic influence of cations

1991 • 11 citations

Block of avian cardiac fast sodium channels by tetrodotoxin is enhanced by repetitive depolarization but not by steady depolarization*

1984 • 4 citations