CHOLESTEROL METABOLISM IN MAN

The plasma lecithin:cholesterol acyltransferase reaction

1968 • 2,415 citations

Fat Transport in Lipoproteins — An Integrated Approach to Mechanisms and Disorders

1967 • 1,945 citations

The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observations

1972 • 1,831 citations

THE SMOOTH MUSCLE CELL

1971 • 1,571 citations

Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

1974 • 1,481 citations

Hyperlipidemia in Coronary Heart Disease II. GENETIC ANALYSIS OF LIPID LEVELS IN 176 FAMILIES AND DELINEATION OF A NEW INHERITED DISORDER, COMBINED HYPERLIPIDEMIA

1973 • 1,457 citations

The physicochemical basis of cholesterol gallstone formation in man

1968 • 1,056 citations

A multivariate analysis of the risk of coronary heart disease in Framingham

1967 • 947 citations

Serum Lipoproteins and Coronary Heart Disease in a Population Study of Hawaii Japanese Men

1976 • 889 citations

Quantitative isolation and gas–liquid chromatographic analysis of total dietary and fecal neutral steroids

1965 • 760 citations

Hyperlipidemia in Coronary Heart Disease I. LIPID LEVELS IN 500 SURVIVORS OF MYOCARDIAL INFARCTION

1973 • 630 citations

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts

1974 • 545 citations

Cholesterol Solubility in Bile. EVIDENCE THAT SUPERSATURATED BILE IS FREQUENT IN HEALTHY MAN

1973 • 527 citations

The Biological Synthesis of Cholesterol

1965 • 524 citations

Risk Factors in Coronary Heart Disease: An Evaluation of Several Serum Lipids as Predictors of Coronary Heart Disease: The Framingham Study

1964 • 522 citations

Metabolism of β-sitosterol in man

1970 • 501 citations

Lipoprotein Uptake and Metabolism by Rat Aortic Smooth Muscle Cells in Tissue Culture

1974 • 486 citations

Familial Hypercholesterolemia: Identification of a Defect in the Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity Associated with Overproduction of Cholesterol

1973 • 442 citations

The Intraluminal Phase of Fat Digestion in Man: The Lipid Content of the Micellar and Oil Phases of Intestinal Content Obtained during Fat Digestion and Absorption*

1964 • 434 citations

Interruption of the enterohepatic circulation of bile acids in man: comparative effects of cholestyramine and ileal exclusion on cholesterol metabolism.

1971 • 404 citations

Effects of obesity and caloric intake on biliary lipid metabolism in man.

1975 • 389 citations

Diminished Bile Acid Pool Size in Patients with Gallstones

1970 • 378 citations

Regression of Coronary Atheromatosis in Rhesus Monkeys

1970 • 376 citations

On the metabolic conversion of human plasma very low density lipoprotein to low density lipoprotein

1973 • 339 citations

The mechanism whereby bile acid micelles increase the rate of fatty acid and cholesterol uptake into the intestinal mucosal cell.

1976 • 334 citations

Inhibition of Sterol Synthesis in Cultured Mouse Cells by Cholesterol Derivatives Oxygenated in the Side Chain

1974 • 330 citations

Effects of dietary cholesterol on the regulation of total body cholesterol in man

1971 • 321 citations

Inhibition of Sterol Synthesis in Cultured Mouse Cells by 7α-Hydroxycholesterol, 7β-Hydroxycholesterol, and 7-Ketocholesterol

1973 • 320 citations

Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts.

1975 • 317 citations

Physico-chemical state of lipids in intestinal content during their digestion and absorption.

1962 • 315 citations

Myocardial infarction in the familial forms of hypertriglyceridemia

1976 • 308 citations

Lipid metabolism and atherosclerosis

1951 • 298 citations

Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat

1967 • 296 citations

The interaction of cholesterol absorption and cholesterol synthesis in man

1969 • 290 citations

A MECHANISM BY WHICH HIGH-DENSITY LIPOPROTEINS MAY SLOW THE ATHEROGENIC PROCESS

1976 • 275 citations

STUDIES ON THE SITE OF THE FEEDBACK CONTROL OF CHOLESTEROL SYNTHESIS*†

1960 • 271 citations

The inheritance of essential familial hypercholesterolemia

1964 • 268 citations

Quantitative and qualitative serum lipoprotein analysis

1975 • 264 citations

The removal of cholesterol from aortic smooth muscle cells in culture and landschutz ascites cells by fractions of human high-density apolipoprotein

1975 • 264 citations

The effects of unsaturated dietary fats on absorption, excretion, synthesis, and distribution of cholesterol in man

1970 • 264 citations

Effect of Biliary Drainage on Individual Reactions in the Conversion of Cholesterol to Taurocholic Acid

1967 • 261 citations

Cholesterol Production in Obesity

1971 • 259 citations

Effects of polyunsaturated fats on lipid metabolism in patients with hypertriglyceridemia.

1975 • 256 citations

Biochemical site of regulation of bile acid biosynthesis in the rat

1970 • 250 citations

A Physiological Method for Estimation of Hepatic Secretion of Biliary Lipids in Man

1972 • 243 citations

Mechanisms of Lithogenic Bile Formation in American Indian Women with Cholesterol Gallstones

1972 • 235 citations

Feedback regulation of bile acid biosynthesis in the rat

1969 • 234 citations

Regression and Progression of Early Femoral Atherosclerosis in Treated Hyperlipoproteinemic Patients

1977 • 234 citations

DIET AND THE EPIDEMIOLOGY OF CORONARY HEART DISEASE

1957 • 225 citations

THE METABOLISM OF CHYLOMICRON CHOLESTEROL ESTER IN THE RAT

1962 • 221 citations

Cholesterol synthesis in the squirrel monkey: relative rates of synthesis in various tissues and mechanisms of control

1968 • 220 citations

Familial Hypercholesterolemia: A Genetic Defect in the Low-Density Lipoprotein Receptor

1976 • 220 citations

Consequences of blocked sterol synthesis in cultured cells. DNA synthesis and membrane composition.

1977 • 216 citations

Evaluation of Serum Lipoprotein and Cholesterol Measurements as Predictors of Clinical Complications of Atherosclerosis

1956 • 215 citations

Distribution and turnover of cholesterol in humans

1969 • 214 citations

In vivo demonstration of the circadian rhythm of cholesterol biosynthesis inthe liver and intestine of the rat

1972 • 213 citations

Metabolism of lethocholate in healthy man. I. Biotransformation and biliary excretion of intravenously administered lithocholate, lithocholylglycine, and their sulfates.

1975 • 194 citations

CHOLESTEROL METABOLISM

1953 • 188 citations

CHOLESTEROL SYNTHESIS BY LIVER

1953 • 187 citations

Absorption of Cholesterol from a Micellar Solution: Intestinal Perfusion Studies in Man*

1967 • 186 citations

C14-CHOLESTEROL

1952 • 179 citations

The role of bile salts in controlling the rate of intestinal cholesterogenesis

1968 • 175 citations

Quantitative studies of the metabolism of chylomicron triglycerides and cholesterol by liver and extrahepatic tissues of sheep and dogs

1971 • 173 citations

Quantitative and qualitative serum lipoprotein analysis

1975 • 173 citations

Regulation of cholesterol biosynthesis in rat liver: Diurnal changes of activity and influence of bile acids

1969 • 168 citations

On the Regulation of‘ Bile Acid Formation in the Rat Liver

1958 • 164 citations

METABOLISM OF CONSTITUENT LIPIDS OF DOG CHYLOMICRONS*

1963 • 163 citations

Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis

1974 • 161 citations

Metabolism of lithocholate in healthy man. II. Enterohepatic circulation.

1975 • 155 citations

Uptake and degradation of low density lipoprotein by swine arterial smooth muscle cells with inhibition of cholesterol biosynthesis

1976 • 153 citations

Cholesterol Metabolism in Human Obesity

1973 • 152 citations

SUPPRESSION OF HEPATIC CHOLESTEROL SYNTHESIS IN THE RAT BY CHOLESTEROL FEEDING

1954 • 152 citations

Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia.

1975 • 148 citations

Metabolism of apoprotein B of plasma very low density lipoproteins in the rat.

1975 • 147 citations

The removal of cholesterol from landschütz ascites cells by high-density apolipoprotein

1973 • 142 citations

Diurnal Variation in Biliary Lipid Composition

1973 • 141 citations

Metabolism of cholesteryl esters of rat very low density lipoproteins.

1975 • 132 citations

Lowering of Plasma Cholesterol and Enhanced Sterol Excretion with the Consumption of Polyunsaturated Ruminant Fats

1973 • 128 citations

Determination of cholesterol absorption in man by intestinal perfusion

1977 • 127 citations

Cholesterol synthesis in the intestine of man: regional differences and control mechanisms

1971 • 111 citations

Control of 3-hydroxy-3-methylglutaryl coenzyme A reductase by endogenously synthesized sterols in vitro and in vivo.

1977 • 110 citations

FEEDBACK CONTROL OF CHOLESTEROL SYNTHESIS IN MAN*

1963 • 107 citations

Biliary lipid outputs in young women with cholesterol gallstones

1974 • 103 citations

Synthesis and Secretion of Plasma Lipoproteins

1972 • 102 citations

Degradation of I125-labelled serum low density lipoprotein in normal and estrogen-treated male rats

1971 • 102 citations

Paradoxical Increase in Rate of Catabolism of Low-Density Lipoproteins after Hepatectomy

1974 • 100 citations

An evaluation of the relative merits of two methods for measuring the balance of sterols in man: isotopic balance versus chromatographic analysis.

1966 • 98 citations

DIETARY REGULATION OF CHOLESTEROL METABOLISM

1966 • 95 citations

Sterol and bile acid excretion in man and the effects of dietary fat.

1965 • 92 citations

The role of the liver in the turnover of plasma cholesterol

1955 • 92 citations

Binding, internalization, and degradation of low density lipoprotein by normal human fibroblasts and by fibroblasts from a case of homozygous familial hypercholesterolemia.

1976 • 87 citations

Mechanism of induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human leukocytes.

1977 • 86 citations

In vitro effects of serum proteins and lipids on lipid synthesis in human skin fibroblasts and leukocytes grown in culture

1972 • 80 citations

Plasma Lipoproteins in Familial Lecithin:Cholesterol Acyltransferase Deficiency FURTHER STUDIES OF VERY LOW AND LOW DENSITY LIPOPROTEIN ABNORMALITIES

1973 • 75 citations

Cholesterol Biosynthesis: Mevalonate Synthesis Inhibited by Bile Salts

1965 • 72 citations

Familial hypercholesterolemia, xanthomatosis and coronary heart disease

1959 • 72 citations

Diurnal variation of HMG CoA reductase activity in rat intestine

1972 • 70 citations

Hypercholesteremia with predisposition to atherosclerosis

1951 • 68 citations

Turnover of Plasma Esterified Cholesterol in Normocholesterolemic and Hypercholesterolemic Subjects and Its Relation to Body Build*

1967 • 65 citations

Role of Fat and Fatty Acid in Absorption of Dietary Cholesterol

1954 • 63 citations

Relationship of Bile Acid Pool Size to Biliary Lipid Excretion and the Formation of Litho Genic Bile in Man

1971 • 56 citations

Regression of atherosclerotic stenosing lesions of the renal arteries and spontaneous cure of systemic hypertension through control of hyperlipidemia

1976 • 46 citations

Cholesterol, Atherosclerosis, Ischemic Heart Disease, and Stroke

1970 • 46 citations

A direct relationship between the amount of sterol lost from rat hepatocytes and the increase in activity of HMG-CoA reductase

1976 • 36 citations

Plasma lipoprotein metabolism in familial lecithin:cholesterol acyltransferase deficiency.

1974 • 29 citations

CHOLESTEROL METABOLISM IN MAN. STUDIES ON ABSORPTION.

1963 • 28 citations

Cholesterol synthesis by the gastrointestinal tract

1971 • 25 citations

EVALUATION of serum lipoprotein and cholesterol measurements as predictors of clinical complications of atherosclerosis; report of a cooperative study of lipoproteins and atherosclerosis.

1956 • 24 citations

[Lipid metabolism and atherosclerosis].

1963 • 22 citations

The Effect of Dietary Fat on the Intestinal Cholesterol Absorption and on the Cholesterol Metabolism in the Liver of Rats¹

1955 • 21 citations