Molecular evolution of ubiquitous β‐lactamases towards extended‐spectrum enzymes active against newer β‐lactam antibiotics

The structure of β-lactamases

1980 • 1,705 citations

Extended-spectrum beta-lactamases

1989 • 808 citations

Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.

1978 • 791 citations

ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.

1981 • 384 citations

Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel β-lactamase

1987 • 366 citations

Bacterial Resistance to β-Lactam Antibiotics: Crystal Structure of β-Lactamase from Staphylococcus aureus PC1 at 2.5 Å Resolution

1987 • 349 citations

The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 <scp>dd</scp>-peptidase family

1988 • 334 citations

Classification of beta-lactamases: groups 1, 2a, 2b, and 2b'

1989 • 224 citations

Classification of beta-lactamases: groups 2c, 2d, 2e, 3, and 4

1989 • 176 citations

Partial amino acid sequence of penicillinase coded by Escherichia coli plasmid R6K.

1978 • 159 citations

β-LACTAMASES

1984 • 159 citations

β-Lactam Antibiotics: Structural Relationships Affecting in Vitro Activity and Pharmacologic Properties

1986 • 142 citations

Dissemination of the novel plasmid-mediated beta-lactamase CTX-1, which confers resistance to broad-spectrum cephalosporins, and its inhibition by beta-lactamase inhibitors

1988 • 118 citations

SHV-5, a novel SHV-type beta-lactamase that hydrolyzes broad-spectrum cephalosporins and monobactams

1989 • 117 citations

Epidemiology of extended spectrum β-lactamases

1989 • 113 citations

Novel R-factor borne β-lactamase of Escherichia coli confering resistance to cephalosporins

1987 • 106 citations

Single amino acid substitution between SHV‐1 β‐lactamase and cefotaxime‐hydrolyzing SHV‐2 enzyme

1988 • 105 citations

Novel plasmid-mediated beta-lactamase in clinical isolates of Klebsiella pneumoniae more resistant to ceftazidime than to other broad-spectrum cephalosporins

1988 • 104 citations

An X-ray-crystallographic study of β-lactamase II from Bacillus cereus at 0.35 nm resolution

1987 • 102 citations

The amino acid sequence of Staphylococcus aureus penicillinase

1975 • 98 citations

Complete amino acid sequence of p453-plasmid-mediated PIT-2 β-lactamase (SHV-1)

1988 • 92 citations

Thiol-beta-lactamase: replacement of the active-site serine of RTEM beta-lactamase by a cysteine residue.

1982 • 84 citations

The TEM-3 β-lactamase, which hydrolyzes broad-spectrum cephalosporins, is derived from the TEM-2 penicillinase by two amino acid substitutions

1988 • 82 citations

Close evolutionary relationship between the chromosomally encoded β lactamase gene of Klebsiellapneumoniae and the TEM β‐lactamase gene mediated by R plasmids

1986 • 82 citations

Characterization of the plasmid genes blaT-4 and blaT-5 which encode the broad-spectrum β-lactamases TEM-4 and TEM-5 in Enterobacteriaceae

1989 • 81 citations

Molecular characterization of the gene encoding SHV-3 beta-lactamase responsible for transferable cefotaxime resistance in clinical isolates of Klebsiella pneumoniae

1989 • 78 citations

Directed selective pressure on a β-lactamase to analyse molecular changes involved in development of enzyme function

1976 • 69 citations

Active-site mutants of .beta.-lactamase: use of an inactive double mutant to study requirements for catalysis

1986 • 52 citations

Substitution of serine for arginine in position 162 of TEM-type β-lactamases extends the substrate profile of mutant enzymes, TEM-7 and TEM-101, to ceftazidime and aztreonam

1989 • 46 citations

Structural features related to hydrolytic activity against ceftazidime of plasmid-mediated SHV-type CAZ-5 beta-lactamase

1989 • 45 citations

R Factor-Mediated and Chromosomal Resistance to Ampicillin in Escherichia coli

1974 • 42 citations

Oxacillin‐hydrolysing β‐lactamases

1989 • 36 citations

Comparative study of five plasmid-mediated ceftazidimases isolated in Klebsiella pneumoniae

1989 • 30 citations

Single substitution in amino acid composition between TEM-2 β-lactamase and a variant with altered kinetic constants

1983 • 5 citations