Lysosomal targeting and accumulation of aminoglycoside antibiotics in sensory hair cells

Handbook of Sensory Physiology

1975 • 7,212 citations

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

1995 • 6,103 citations

Mitochondrial ribosomal RNA mutation associated with both antibiotic–induced and non–syndromic deafness

1993 • 1,173 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.

1989 • 588 citations

Membrane Traffic in Endocytosis: Insights from Cell-Free Assays

1989 • 369 citations

Bacterial protein toxins penetrate cells via a four‐step mechanism

1994 • 224 citations

Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment

1985 • 222 citations

Lysosomes as key organelles in the pathogenesis of prion encephalopathies

1992 • 179 citations

Effects of noise and ototoxic drugs at the cellular level in the cochlea: A review

1986 • 158 citations

Molecular mechanisms of drug-induced hearing loss

1986 • 155 citations

Endocytosis of a cytotoxic human high density lipoprotein results in disruption of acidic intracellular vesicles and subsequent killing of African trypanosomes.

1994 • 124 citations

Biochemical Basis of Aminoglycoside Ototoxicity

1993 • 124 citations

Endocytosis of aminoglycoside antibiotics in sensory hair cells

1995 • 117 citations

Use of glycyl-<scp>l</scp>-phenylalanine 2-naphthylamide, a lysosome-disrupting cathepsin C substrate, to distinguish between lysosomes and prelysosomal endocytic vacuoles

1994 • 110 citations

Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro

1994 • 89 citations

Endocytosis and intracellular sorting of ricin and Shiga toxin

1994 • 84 citations

Drug Ototoxicity

1986 • 78 citations

Ultrastructural localization of gentamicin in the cochlea

1990 • 76 citations

ELECTRON HISTOCHEMICAL LOCALIZATION OF ACID PHOSPHATASE ACTIVITY IN THE SMALL INTESTINE OF MOUSE

1964 • 74 citations

Formation of a cytotoxic metabolite from gentamicin by liver

1990 • 72 citations

Gentamicin Uptake by Cochlear Hair Cells Precedes Hearing Impairment during Chronic Treatment

1993 • 70 citations

Subcellular distribution of gentamicin in proximal tubular cells, determined by immunogold labeling

1991 • 65 citations

Cellular and subcellular localization of tritiated gentamicin in the guinea pig cochlea following combined treatment with ethacrynic acid

1992 • 59 citations

Drug Ototoxicity

1976 • 50 citations

Subcellular localization of tobramycin and vancomycin given alone and in combination in proximal tubular cells, determined by immunogold labeling

1992 • 40 citations

LA GENTAMICINE ADMINISTREE A LONG TERME PENETRE DANS LES CELLULES CILIEES DE LA COCHLEE AVANT L'APPARITION D'UN TROUBLE DE L'AUDITION

1993 • 39 citations

Uptake of amikacin by hair cells of the guinea pig cochlea and vestibule and ototoxicity: Comparison with gentamicin

1995 • 38 citations

Tissue Levels of Kanamycin in Correlation with Oto- And Nephrotoxicity

1978 • 35 citations

Apically and basolaterally internalized aminoglycosides colocalize in LLC-PK1 lysosomes and alter cell function

1994 • 33 citations

Cytochemical staining methods for electron microscopy

1992 • 32 citations

The effect of chronic application of kanamycin on stereocilia and their tip links in hair cells of the guinea pig cochlea

1987 • 25 citations

Base-to-apex gradient of cell proliferation in the chick cochlea following kanamycin-induced hair cell loss

1995 • 24 citations

Regenerated hair cells exhibit a transient resistance to aminoglycoside toxicity

1996 • 20 citations

Surface binding and intracellular uptake of gentamicin in the cultured kidney epithelial cell line (LLC-PK1).

1992 • 19 citations

Initial changes in the sensory hair-cell membrane following aminoglycoside administration in a guinea pig model

1989 • 15 citations