Effects of substitutions of amino acids on the thermal stability of the Fv fragments of antibodies

Making antibody fragments using phage display libraries

1991 • 1,195 citations

Assembly of combinatorial antibody libraries on phage surfaces: the gene III site.

1991 • 1,178 citations

Assembly of a Functional Immunoglobulin F _v Fragment in Escherichia coli

1988 • 973 citations

Escherichia coli Secretion of an Active Chimeric Antibody Fragment

1988 • 575 citations

Antibody framework residues affecting the conformation of the hypervariable loops

1992 • 507 citations

A comparison of strategies to stabilize immunoglobulin Fv-fragments

1990 • 469 citations

Equilibrium and kinetic aspects of the interaction of isolated variable and constant domains of light chain with the Fd' fragment of immunoglobulin G

1979 • 61 citations

Effects of substitutions of closely related amino acids at the contact surface in an antigen-antibody complex on thermodynamic parameters

1993 • 52 citations

Development of an artificial antibody system with multiple valency using an Fv fragment fused to a fragment of protein A.

1993 • 51 citations

Folding and interaction of subunits at the antibody combining site

1976 • 45 citations

Monoclonal Antibodies

2020 • 27 citations