Methods to increase enantioselectivity of lipases and esterases

Ionic Liquids—New “Solutions” for Transition Metal Catalysis

2000 • 5,604 citations

Quantitative analyses of biochemical kinetic resolutions of enantiomers

1982 • 2,569 citations

Biotransformations in Organic Chemistry

2000 • 1,292 citations

Lipases: Interfacial Enzymes with Attractive Applications

1998 • 1,174 citations

Enzyme Catalysis in Organic Synthesis

2002 • 844 citations

Hydrolases in Organic Synthesis: Regio- and Stereoselective Biotransformations

1999 • 633 citations

Enzyme catalysis in ionic liquids

2002 • 563 citations

Lipase-Catalyzed Reactions in Ionic Liquids

2000 • 562 citations

Improved Preparation and Use of Room-Temperature Ionic Liquids in Lipase-Catalyzed Enantio- and Regioselective Acylations

2001 • 556 citations

Improved biocatalysts by directed evolution and rational protein design

2001 • 462 citations

Directed evolution of biocatalysts

1999 • 386 citations

Enzyme catalysis in ionic liquids: lipase catalysed kinetic resolution of 1-phenylethanol with improved enantioselectivity

2001 • 353 citations

Biocatalysis in Ionic Liquids: Markedly Enhanced Enantioselectivity of Lipase

2001 • 278 citations

Directed evolution of an enantioselective lipase

2000 • 260 citations

Directed Evolution of an Enantioselective Enzyme through Combinatorial Multiple-Cassette Mutagenesis

2001 • 214 citations

Lipase engineering database

2000 • 179 citations

Novel methods for biocatalyst screening

2001 • 172 citations

Cross-Linked Crystals of Candida rugosa Lipase: Highly Efficient Catalysts for the Resolution of Chiral Esters

1995 • 169 citations

Activity of Lipases and Esterases towards Tertiary Alcohols: Insights into Structure���Function Relationships

2002 • 146 citations

Tailoring new enzyme functions by rational redesign

2000 • 135 citations

Controlling lipase enantioselectivity for organic synthesis

2001 • 132 citations

Improved Enantioselectivity of a Lipase by Rational Protein Engineering

2001 • 125 citations

Drastic solvent effect on lipase-catalyzed enantioselective hydrolysis of prochiral 1,4-dihydropyridines

1992 • 105 citations

Molecular modeling and biocatalysis: explanations, predictions, limitations, and opportunities

2000 • 95 citations

Untitled

2002 • 94 citations

Stereoselectivity of Pseudomonas cepacia lipase toward secondary alcohols: A quantitative model

2000 • 91 citations

Influence of acyl chain length on the enantioselectivity of Candida antarctica lipase B and its thermodynamic components in kinetic resolution of sec-alcohols

2001 • 81 citations

Directed Molecular Evolution of Proteins

2002 • 80 citations

Creation of an Enantioselective Hydrolase by Engineered Substrate-Assisted Catalysis

2001 • 68 citations

Enantioselective Hydrolysis ofd,l-Menthyl Benzoate toL-(-)-Menthol by RecombinantCandida rugosa Lipase LIP1

2002 • 54 citations

Resolution of 1-(2-Naphthyl)ethanol by a Combination of an Enzyme-Catalyzed Kinetic Resolution with a Fluorous Triphasic Separative Reaction

2002 • 53 citations

Separation of Enantiomers by Extraction Based on Lipase-Catalyzed Enantiomer-Selective Fluorous-Phase Labeling

2001 • 52 citations

Cloning, Functional Expression, and Characterization of Recombinant Pig Liver Esterase

2001 • 51 citations

Engineering enzyme specificity

1998 • 49 citations

Enzymes in organic synthesis. 42. Investigation of the effects of the isozymal composition of pig liver esterase on its stereoselectivity in preparative-scale ester hydrolysis of asymmetric synthetic value

1988 • 49 citations

Molecular Modelling of Lipase Catalysed Reactions Prediction of Enantioselectivities.

1999 • 48 citations

By Overexpression in the YeastPichia pastoris to Enhanced Enantioselectivity: New Aspects in the Application of Pig Liver Esterase

2001 • 46 citations

Dimethyl sulfoxide as a co-solvent dramatically enhances the enantioselectivity in lipase-catalysed resolutions of 2-phenoxypropionic acyl derivatives

2001 • 41 citations

Lipase-Catalyzed Resolution of Ibuprofen

2000 • 31 citations

Directed Evolution of Enzymes for Biocatalytic Applications

2001 • 25 citations

Molecular Basis for Enantioselectivity of Lipase from Chromobacterium viscosum toward the Diesters of 2,3-Dihydro-3-(4‘-hydroxyphenyl)-1,1,3-trimethyl-1H-inden-5-ol

2001 • 23 citations

A Dramatic Improvement of Enantioselectivity of Lipase in Organic Solvents by Addition of Aqueous SDS: A Close Correlation between Enantioselectivity and Conformational Flexibility of Lipase

2001 • 22 citations

Computer-aided molecular modeling of the enantioselectivity of Pseudomonas cepacia lipase toward γ- and δ-lactones

2000 • 21 citations

Enantiotopic Selectivity of-Pig Liver Esterase Isoenzymes

1990 • 20 citations

Enhancement of the enantioselectivity of lipase OF catalyzed hydrolysis

2001 • 14 citations

Effects of Chemical Modification of Lipase on Its Enantioselectivity in Organic Solvents

2001 • 12 citations

ChemInform Abstract: Molecular Modeling of Lipase Catalyzed Reactions. Prediction of Enantioselectivities

1999 • 7 citations