Approaches to the study of enzyme mechanisms lactate dehydrogenase

10th Spiers Memorial Lecture. Transfer mechanisms of electronic excitation

1959 • 3,260 citations

Studies on Liver Alcohol Dehydrogenase. I. Equilibria and Initial Reaction Velocities.

1951 • 446 citations

Fluorescence Spectra and Polarization of Glyceraldehyde-3-phosphate and Lactic Dehydrogenase Coenzyme Complexes

1958 • 373 citations

Equilibrium binding of nicotinamide nucleotides to lactate dehydrogenases

1973 • 262 citations

Lactic Dehydrogenase

1959 • 258 citations

Half-of-the-sites reactivity and conformational states of cytidine triphosphate synthetase

1971 • 256 citations

Horse Liver Alcohol Dehydrogenase

1970 • 238 citations

Comprehensive Biochemistry

1967 • 198 citations

pK of the lysine amino group at the active site of acetoacetate decarboxylase

1971 • 195 citations

Enzymes: physical principles

1972 • 191 citations

Structure and Catalytic Activity of Alcohol Dehydrogenases

1964 • 183 citations

Liver Alcohol Dehydrogenase. II. Equilibrium Constants of Binary and Ternary Complexes of Enzyme, Coenzyme, and Caprate, Isobutyramide and Imidazole.

1961 • 177 citations

Ionic properties of an essential histidine residue in pig heart lactate dehydrogenase

1973 • 176 citations

Kinetic Studies of Liver Alcohol Dehydrogenase and pH Effects with Coenzyme Preparations of High Purity

1963 • 158 citations

LACTIC DEHYDROGENASE

1956 • 146 citations

Mechanistic studies on equine liver alcohol dehydrogenase. I. Stoichiometry relation of the coenzyme binding sites to the catalytic sites active in the reduction of aromatic aldehydes in the transient state

1970 • 139 citations

Enhancement of the Activity of Horse Liver Alcohol Dehydrogenase by Modification of Amino Groups at the Active Sites

1970 • 132 citations

The Comparative Enzymology of Lactic Dehydrogenases

1965 • 120 citations

The kinetics of the reversible inhibition of heart lactate dehydrogenase through the formation of the enzyme–oxidized nicotinamide–adenine dinucleotide–pyruvate compound

1968 • 114 citations

Dissociation constants of the liver alcohol dehydrogenase coenzyme complexes

1959 • 109 citations

Transients in the reactions of liver alcohol dehydrogenase

1970 • 109 citations

Horse Liver Alcohol Dehydrogenase

1970 • 104 citations

Lactic Dehydrogenase

1959 • 100 citations

Multiplicity of Binding by Lactate Dehydrogenases^*

1965 • 91 citations

Lactic Dehydrogenase

1967 • 86 citations

Interaction of a spin-labeled analog of nicotinamide adenine dinucleotide with alcohol dehydrogenase. I. Synthesis, kinetics, and electron paramagnetic resonance studies

1969 • 84 citations

Subunit conformation and catalytic function in rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase

1971 • 83 citations

Transients and Relaxation Kinetics of Enzyme Reactions

1971 • 77 citations

On the ternary complex of liver alcohol dehydrogenase with reduced coenzyme and isobutyramide. Effect of p-chloromercuriphenyl sulfonate and stability of the complex

1962 • 77 citations

Protein fluorescence of lactate dehydrogenase

1972 • 74 citations

STUDIES ON LACTIC DEHYDROGENASE OF HEART

1952 • 68 citations

Reactivity and Function of Sulfhydryl Groups in Horse Liver Alcohol Dehydrogenase^*

1965 • 67 citations

Lactic Dehydrogenase

1961 • 65 citations

Porcine Heart Lactate Dehydrogenase

1969 • 63 citations

Evidence for ternary-complex formation with rabbit-muscle lactic acid dehydrogenase, diphosphopyridine nucleotide and pyruvic acid

1961 • 60 citations

Excitation transfer in complexes of horse liver alcohol dehydrogenase

1971 • 58 citations

The use of ternary complexes to study ionizations and isomerizations during catalysis by lactate dehydrogenase

1973 • 55 citations

Lactic Dehydrogenase

1963 • 52 citations

OBSERVATIONS OF NEW PHENOMENA IN THE FLUORESCENCE SPECTRUM OF A DIPHOSPHOPYRIDINE NUCLEOTIDE-LINKED DEHYDROGENASE

1957 • 51 citations

Optical and chemical identification of kinetic steps in trypsin- and chymotrypsin-catalysed reactions

1966 • 48 citations

The Importance of SH-Groups for Enzymic Activity. 7. The Amino Acid Sequence around the Essential SH-Group of Pig Heart Lactate Dehydrogenase, Isoenzyme I.

1967 • 48 citations

Markierung essentieller Aminosäurereste der Lactat-Dehydrogenase aus Schweineherz mit [Carbonyl-¹⁴C]3-[2-Brom-acetyl]-pyridin

1969 • 46 citations

Role of zinc in horse liver alcohol dehydrogenase. II. Coenzyme and substrate binding

1972 • 45 citations

Protein fluorescence of nicotinamide nucleotide-dependent dehydrogenases

1972 • 45 citations

Tryptophan Fluorescence Quenching in Horse Liver Alcohol Dehydrogenase

1970 • 44 citations

The Importance of SH-Groups for Enzymic Activity

1967 • 43 citations

ON RESONANCE TRANSFER OF EXCITATION ENERGY BETWEEN AROMATIC AMINOACIDS IN PROTEINS

1958 • 41 citations

Tryptophan as Intermediate in Dehydrogenase Action

1967 • 40 citations

Transient-kinetic studies of pig muscle lactate dehydrogenase

1971 • 35 citations

Reactivity of the essential thiol group of lactate dehydrogenase and substrate binding

1970 • 32 citations

The resolution of some steps of the reactions of lactate dehydrogenase with its substrates

1968 • 31 citations

Complexes of chicken heart lactic dehydrogenase with coenzymes and substrates

1968 • 29 citations

The Histidines in Liver Alcohol Dehydrogenase

1972 • 28 citations

Zuordnung eines essentiellen Histidinrestes der Lactat-Dehydrogenase zur Substratbindungsstelle

1971 • 23 citations

Dissociation Constants of Bovine Heart Lactate Dehydrogenase-Reduced Coenzyme Compounds.

1963 • 22 citations

Spezifische Modifizierung der Coenzymbindungsstelle von Dehydrogenasen mit dem NAD-ähnlichen Inaktivator [3-(4-Brom-acetylpyridinio)propyl]-adenosin-pyrophosphat

1972 • 20 citations

Lactate Dehydrogenase

1970 • 17 citations

The reactivities of the lysine, cysteine and tyrosine residues of pig heart lactate dehydrogenase in the presence of sulphite

1968 • 17 citations

Änderung der optischen Rotationsdispersion von Lactat-Dehydrogenase aus Schweineherzmuskel nach Zugabe von Harnstoff, Coenzym und SH-blockierenden Reagenzien

1969 • 12 citations

Hydrogen-transfer reactions catalyzed by pyridine nucleotide linked dehydrogenases

1971 • 12 citations

Zum Wirkungsmechanismus der Lactat-Dehydrogenase, VI. Änderung der biochemischen Eigenschaften von Lactat-Dehydrogenase aus Schweineherzmuskel nach Nitrierung mit Tetranitromethan

1971 • 11 citations

COMPLEXES OF PYRIDINE NUCLEOTIDES AND THEIR FUNCTION

1972 • 9 citations

Structure and Mechanism of Lactate Dehydrogenase

1970 • 6 citations

A study of tryptophan tritiation in supernatant malate dehydrogenase from pig heart

1970 • 4 citations